Lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population
Udgivelsesdato: 2006-Jul BACKGROUND: The association between obesity and cardiovascular disease risk differs across populations. Whether such differences in obesity-related risk factors exist within population groups of the same genetic origin but with differences in lifestyle remains to be determin...
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ftsydanskunivpub:oai:sdu.dk:publications/bcd7f790-71f5-11de-9c46-000ea68e967b 2024-05-19T07:41:06+00:00 Lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population Jørgensen, Marit E Borch-Johnsen, Knut Bjerregaard, Peter 2006-07-01 https://portal.findresearcher.sdu.dk/da/publications/bcd7f790-71f5-11de-9c46-000ea68e967b eng eng https://portal.findresearcher.sdu.dk/da/publications/bcd7f790-71f5-11de-9c46-000ea68e967b info:eu-repo/semantics/restrictedAccess Jørgensen , M E , Borch-Johnsen , K & Bjerregaard , P 2006 , ' Lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population ' , American Journal of Clinical Nutrition , vol. 84 , no. 1 , pp. 29-36 . Adult Blood Glucose Blood Pressure Body Mass Index Cardiovascular Diseases Cholesterol HDL Cross-Sectional Studies Denmark Emigration and Immigration Female Food Habits Glucose Tolerance Test Greenland Humans Insulin Inuits Life Style Male Obesity Questionnaires Risk Factors Sex Factors Triglycerides article 2006 ftsydanskunivpub 2024-05-01T00:14:11Z Udgivelsesdato: 2006-Jul BACKGROUND: The association between obesity and cardiovascular disease risk differs across populations. Whether such differences in obesity-related risk factors exist within population groups of the same genetic origin but with differences in lifestyle remains to be determined. OBJECTIVE: The aim was to analyze whether obesity was associated with the same degree of metabolic disturbances in 2 groups of genetically homogeneous Inuit who were exposed to considerable differences in lifestyle. DESIGN: We studied obesity and cardiovascular disease risk factors in a cross-sectional population survey of 2311 Inuit living in Denmark (n = 995) or Greenland (n = 1316). The participants received an oral-glucose-tolerance test. Blood tests were supplemented by structured interviews and anthropometric and blood pressure measurements. RESULTS: The trend in the association between obesity and metabolic effects was not significantly different in the Inuit populations, but the values of several risk factors were significantly different. At any given level of obesity, Inuit residents in Greenland had lower blood pressure and lower concentrations of triacylglycerol and postchallenge plasma glucose and insulin than did the Inuit migrants in Denmark. The trend in the association with obesity categories was different only for HDL cholesterol, with higher concentrations observed in women Inuit migrants in Denmark than in women Inuit residents in Greenland. CONCLUSIONS: The health risk associated with obesity clearly varies within groups of Inuit living in Greenland and Inuit migrants living in Denmark. The findings indicate that lifestyle factors modify the cardiovascular disease risk associated with obesity. Article in Journal/Newspaper Greenland inuit inuits University of Southern Denmark Research Portal |
institution |
Open Polar |
collection |
University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
Adult Blood Glucose Blood Pressure Body Mass Index Cardiovascular Diseases Cholesterol HDL Cross-Sectional Studies Denmark Emigration and Immigration Female Food Habits Glucose Tolerance Test Greenland Humans Insulin Inuits Life Style Male Obesity Questionnaires Risk Factors Sex Factors Triglycerides |
spellingShingle |
Adult Blood Glucose Blood Pressure Body Mass Index Cardiovascular Diseases Cholesterol HDL Cross-Sectional Studies Denmark Emigration and Immigration Female Food Habits Glucose Tolerance Test Greenland Humans Insulin Inuits Life Style Male Obesity Questionnaires Risk Factors Sex Factors Triglycerides Jørgensen, Marit E Borch-Johnsen, Knut Bjerregaard, Peter Lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population |
topic_facet |
Adult Blood Glucose Blood Pressure Body Mass Index Cardiovascular Diseases Cholesterol HDL Cross-Sectional Studies Denmark Emigration and Immigration Female Food Habits Glucose Tolerance Test Greenland Humans Insulin Inuits Life Style Male Obesity Questionnaires Risk Factors Sex Factors Triglycerides |
description |
Udgivelsesdato: 2006-Jul BACKGROUND: The association between obesity and cardiovascular disease risk differs across populations. Whether such differences in obesity-related risk factors exist within population groups of the same genetic origin but with differences in lifestyle remains to be determined. OBJECTIVE: The aim was to analyze whether obesity was associated with the same degree of metabolic disturbances in 2 groups of genetically homogeneous Inuit who were exposed to considerable differences in lifestyle. DESIGN: We studied obesity and cardiovascular disease risk factors in a cross-sectional population survey of 2311 Inuit living in Denmark (n = 995) or Greenland (n = 1316). The participants received an oral-glucose-tolerance test. Blood tests were supplemented by structured interviews and anthropometric and blood pressure measurements. RESULTS: The trend in the association between obesity and metabolic effects was not significantly different in the Inuit populations, but the values of several risk factors were significantly different. At any given level of obesity, Inuit residents in Greenland had lower blood pressure and lower concentrations of triacylglycerol and postchallenge plasma glucose and insulin than did the Inuit migrants in Denmark. The trend in the association with obesity categories was different only for HDL cholesterol, with higher concentrations observed in women Inuit migrants in Denmark than in women Inuit residents in Greenland. CONCLUSIONS: The health risk associated with obesity clearly varies within groups of Inuit living in Greenland and Inuit migrants living in Denmark. The findings indicate that lifestyle factors modify the cardiovascular disease risk associated with obesity. |
format |
Article in Journal/Newspaper |
author |
Jørgensen, Marit E Borch-Johnsen, Knut Bjerregaard, Peter |
author_facet |
Jørgensen, Marit E Borch-Johnsen, Knut Bjerregaard, Peter |
author_sort |
Jørgensen, Marit E |
title |
Lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population |
title_short |
Lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population |
title_full |
Lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population |
title_fullStr |
Lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population |
title_full_unstemmed |
Lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population |
title_sort |
lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population |
publishDate |
2006 |
url |
https://portal.findresearcher.sdu.dk/da/publications/bcd7f790-71f5-11de-9c46-000ea68e967b |
genre |
Greenland inuit inuits |
genre_facet |
Greenland inuit inuits |
op_source |
Jørgensen , M E , Borch-Johnsen , K & Bjerregaard , P 2006 , ' Lifestyle modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population ' , American Journal of Clinical Nutrition , vol. 84 , no. 1 , pp. 29-36 . |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/bcd7f790-71f5-11de-9c46-000ea68e967b |
op_rights |
info:eu-repo/semantics/restrictedAccess |
_version_ |
1799480699495907328 |