High Prevalence of Dystonia in the Faroe Islands:A Population-Based Study
Background: There are fewer than 5 population-based studies of dystonia worldwide. Only one utilized a movement disorders neurologist. Given the potential for founder effects, and the highly genetic nature of dystonia, the Faroe Islands provide a particularly interesting setting to study the prevale...
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ftsydanskunivpub:oai:sdu.dk:publications/b9a5093e-f29a-44fe-b929-b457bd4af65f 2023-05-15T16:10:38+02:00 High Prevalence of Dystonia in the Faroe Islands:A Population-Based Study Louis, Elan D. Eliasen, Eina H. Kim, Christine Y. Ferrer, Monica Gaini, Shahin Petersen, Maria Skaalum 2019-08 https://portal.findresearcher.sdu.dk/da/publications/b9a5093e-f29a-44fe-b929-b457bd4af65f https://doi.org/10.1159/000502455 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881520/pdf/nihms-1045710.pdf eng eng info:eu-repo/semantics/openAccess Louis , E D , Eliasen , E H , Kim , C Y , Ferrer , M , Gaini , S & Petersen , M S 2019 , ' High Prevalence of Dystonia in the Faroe Islands : A Population-Based Study ' , Neuroepidemiology , vol. 53 , no. 3-4 , pp. 220–224 . https://doi.org/10.1159/000502455 Dystonia Faroe Islands Prevalence Two-phase population-based design article 2019 ftsydanskunivpub https://doi.org/10.1159/000502455 2022-08-14T10:17:31Z Background: There are fewer than 5 population-based studies of dystonia worldwide. Only one utilized a movement disorders neurologist. Given the potential for founder effects, and the highly genetic nature of dystonia, the Faroe Islands provide a particularly interesting setting to study the prevalence of dystonia. Objective: To estimate the prevalence of dystonia. Methods: We used a 2-phase, population-based design, screening 1,334 randomly selected Faroese individuals aged ≥40 years from which a subsample of 227 participated in an in-person clinical evaluation. Dystonia was assessed by 2 movement disorder neurologists using videotaped examinations. Results: Two of 227 (0.88%, 95% CI -0.33 to 2.09%) were diagnosed with cervical or segmental dystonia. An unusual form of thumb flexion dystonia was noted in 75 more, yielding a combined prevalence of 33.92% (95% CI 27.73-40.11%). Conclusions: The prevalence of cervical or segmental dystonia was as high as in one prior population-based study using similar methods. Furthermore, an unusual form of thumb flexion dystonia was uncovered, which yielded an extraordinarily high prevalence of dystonia in this population. Although our methods likely contributed to more complete capture of subtle dystonia, founder effects are highly likely to have been an additional major contributor to these findings. Article in Journal/Newspaper Faroe Islands University of Southern Denmark Research Portal Faroe Islands Thumb ENVELOPE(-64.259,-64.259,-65.247,-65.247) Neuroepidemiology 53 3-4 220 224 |
institution |
Open Polar |
collection |
University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
Dystonia Faroe Islands Prevalence Two-phase population-based design |
spellingShingle |
Dystonia Faroe Islands Prevalence Two-phase population-based design Louis, Elan D. Eliasen, Eina H. Kim, Christine Y. Ferrer, Monica Gaini, Shahin Petersen, Maria Skaalum High Prevalence of Dystonia in the Faroe Islands:A Population-Based Study |
topic_facet |
Dystonia Faroe Islands Prevalence Two-phase population-based design |
description |
Background: There are fewer than 5 population-based studies of dystonia worldwide. Only one utilized a movement disorders neurologist. Given the potential for founder effects, and the highly genetic nature of dystonia, the Faroe Islands provide a particularly interesting setting to study the prevalence of dystonia. Objective: To estimate the prevalence of dystonia. Methods: We used a 2-phase, population-based design, screening 1,334 randomly selected Faroese individuals aged ≥40 years from which a subsample of 227 participated in an in-person clinical evaluation. Dystonia was assessed by 2 movement disorder neurologists using videotaped examinations. Results: Two of 227 (0.88%, 95% CI -0.33 to 2.09%) were diagnosed with cervical or segmental dystonia. An unusual form of thumb flexion dystonia was noted in 75 more, yielding a combined prevalence of 33.92% (95% CI 27.73-40.11%). Conclusions: The prevalence of cervical or segmental dystonia was as high as in one prior population-based study using similar methods. Furthermore, an unusual form of thumb flexion dystonia was uncovered, which yielded an extraordinarily high prevalence of dystonia in this population. Although our methods likely contributed to more complete capture of subtle dystonia, founder effects are highly likely to have been an additional major contributor to these findings. |
format |
Article in Journal/Newspaper |
author |
Louis, Elan D. Eliasen, Eina H. Kim, Christine Y. Ferrer, Monica Gaini, Shahin Petersen, Maria Skaalum |
author_facet |
Louis, Elan D. Eliasen, Eina H. Kim, Christine Y. Ferrer, Monica Gaini, Shahin Petersen, Maria Skaalum |
author_sort |
Louis, Elan D. |
title |
High Prevalence of Dystonia in the Faroe Islands:A Population-Based Study |
title_short |
High Prevalence of Dystonia in the Faroe Islands:A Population-Based Study |
title_full |
High Prevalence of Dystonia in the Faroe Islands:A Population-Based Study |
title_fullStr |
High Prevalence of Dystonia in the Faroe Islands:A Population-Based Study |
title_full_unstemmed |
High Prevalence of Dystonia in the Faroe Islands:A Population-Based Study |
title_sort |
high prevalence of dystonia in the faroe islands:a population-based study |
publishDate |
2019 |
url |
https://portal.findresearcher.sdu.dk/da/publications/b9a5093e-f29a-44fe-b929-b457bd4af65f https://doi.org/10.1159/000502455 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881520/pdf/nihms-1045710.pdf |
long_lat |
ENVELOPE(-64.259,-64.259,-65.247,-65.247) |
geographic |
Faroe Islands Thumb |
geographic_facet |
Faroe Islands Thumb |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Louis , E D , Eliasen , E H , Kim , C Y , Ferrer , M , Gaini , S & Petersen , M S 2019 , ' High Prevalence of Dystonia in the Faroe Islands : A Population-Based Study ' , Neuroepidemiology , vol. 53 , no. 3-4 , pp. 220–224 . https://doi.org/10.1159/000502455 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1159/000502455 |
container_title |
Neuroepidemiology |
container_volume |
53 |
container_issue |
3-4 |
container_start_page |
220 |
op_container_end_page |
224 |
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1765995800420155392 |