Can Acute Cough Characteristics From Sound Recordings Differentiate Common Respiratory Illnesses in Children?:A Comparative Prospective Study
BACKGROUND: Acute respiratory illnesses cause substantial morbidity worldwide. Cough is a common symptom in these childhood respiratory illnesses, but no large cohort data are available on whether various cough characteristics can differentiate between these etiologies. RESEARCH QUESTION: Can variou...
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ftsydanskunivpub:oai:sdu.dk:publications/b1473a67-01de-4fe3-822e-5bc3eedec230 2023-05-15T16:16:59+02:00 Can Acute Cough Characteristics From Sound Recordings Differentiate Common Respiratory Illnesses in Children?:A Comparative Prospective Study Bisballe-Müller, Nina Chang, Anne B. Plumb, Erin J. Oguoma, Victor M. Halken, Susanne McCallum, Gabrielle B. 2021-01 https://portal.findresearcher.sdu.dk/da/publications/b1473a67-01de-4fe3-822e-5bc3eedec230 https://doi.org/10.1016/j.chest.2020.06.067 eng eng info:eu-repo/semantics/closedAccess Bisballe-Müller , N , Chang , A B , Plumb , E J , Oguoma , V M , Halken , S & McCallum , G B 2021 , ' Can Acute Cough Characteristics From Sound Recordings Differentiate Common Respiratory Illnesses in Children? A Comparative Prospective Study ' , Chest , vol. 159 , no. 1 , pp. 259-269 . https://doi.org/10.1016/j.chest.2020.06.067 acute respiratory infection asthma cough pediatrics sound recording article 2021 ftsydanskunivpub https://doi.org/10.1016/j.chest.2020.06.067 2022-08-14T10:40:21Z BACKGROUND: Acute respiratory illnesses cause substantial morbidity worldwide. Cough is a common symptom in these childhood respiratory illnesses, but no large cohort data are available on whether various cough characteristics can differentiate between these etiologies. RESEARCH QUESTION: Can various clinically based cough characteristics (frequency [daytime/ nighttime], the sound itself, or type [wet/dry]) be used to differentiate common etiologies (asthma, bronchiolitis, pneumonia, other acute respiratory infections) of acute cough in children? STUDY DESIGN AND METHODS: Between 2017 and 2019, children aged 2 weeks to ≤16 years, hospitalized with asthma, bronchiolitis, pneumonia, other acute respiratory infections, or control subjects were enrolled. Spontaneous coughs were digitally recorded over 24 hours except for the control subjects, who provided three voluntary coughs. Coughs were extracted and frequency defined (coughs/hour). Cough sounds and type were assessed independently by two observers blinded to the clinical data. Cough scored by a respiratory specialist was compared with discharge diagnosis using agreement (Cohen's kappa coefficient [қ]), sensitivity, and specificity. Caregiver-reported cough scores were related with objective cough frequency using Spearman coefficient (rs). RESULTS: A cohort of 148 children (n = 118 with respiratory illnesses, n = 30 control subjects), median age = 2.0 years (interquartile range, 0.7-3.9), 58% males, and 50% First Nations children were enrolled. In those with respiratory illnesses, caregiver-reported cough scores and wet cough (range, 42%-63%) was similar. Overall agreement in diagnosis between the respiratory specialist and discharge diagnosis was slight (қ = 0.13; 95% CI, 0.03 to 0.22). Among diagnoses, specificity (8%-74%) and sensitivity (53%-100%) varied. Interrater agreement in cough type (wet/dry) between blinded observers was almost perfect (қ = 0.89; 95% CI, 0.81 to 0.97). Objective cough frequency was significantly correlated with reported cough scores ... Article in Journal/Newspaper First Nations University of Southern Denmark Research Portal Chest 159 1 259 269 |
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University of Southern Denmark Research Portal |
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ftsydanskunivpub |
language |
English |
topic |
acute respiratory infection asthma cough pediatrics sound recording |
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acute respiratory infection asthma cough pediatrics sound recording Bisballe-Müller, Nina Chang, Anne B. Plumb, Erin J. Oguoma, Victor M. Halken, Susanne McCallum, Gabrielle B. Can Acute Cough Characteristics From Sound Recordings Differentiate Common Respiratory Illnesses in Children?:A Comparative Prospective Study |
topic_facet |
acute respiratory infection asthma cough pediatrics sound recording |
description |
BACKGROUND: Acute respiratory illnesses cause substantial morbidity worldwide. Cough is a common symptom in these childhood respiratory illnesses, but no large cohort data are available on whether various cough characteristics can differentiate between these etiologies. RESEARCH QUESTION: Can various clinically based cough characteristics (frequency [daytime/ nighttime], the sound itself, or type [wet/dry]) be used to differentiate common etiologies (asthma, bronchiolitis, pneumonia, other acute respiratory infections) of acute cough in children? STUDY DESIGN AND METHODS: Between 2017 and 2019, children aged 2 weeks to ≤16 years, hospitalized with asthma, bronchiolitis, pneumonia, other acute respiratory infections, or control subjects were enrolled. Spontaneous coughs were digitally recorded over 24 hours except for the control subjects, who provided three voluntary coughs. Coughs were extracted and frequency defined (coughs/hour). Cough sounds and type were assessed independently by two observers blinded to the clinical data. Cough scored by a respiratory specialist was compared with discharge diagnosis using agreement (Cohen's kappa coefficient [қ]), sensitivity, and specificity. Caregiver-reported cough scores were related with objective cough frequency using Spearman coefficient (rs). RESULTS: A cohort of 148 children (n = 118 with respiratory illnesses, n = 30 control subjects), median age = 2.0 years (interquartile range, 0.7-3.9), 58% males, and 50% First Nations children were enrolled. In those with respiratory illnesses, caregiver-reported cough scores and wet cough (range, 42%-63%) was similar. Overall agreement in diagnosis between the respiratory specialist and discharge diagnosis was slight (қ = 0.13; 95% CI, 0.03 to 0.22). Among diagnoses, specificity (8%-74%) and sensitivity (53%-100%) varied. Interrater agreement in cough type (wet/dry) between blinded observers was almost perfect (қ = 0.89; 95% CI, 0.81 to 0.97). Objective cough frequency was significantly correlated with reported cough scores ... |
format |
Article in Journal/Newspaper |
author |
Bisballe-Müller, Nina Chang, Anne B. Plumb, Erin J. Oguoma, Victor M. Halken, Susanne McCallum, Gabrielle B. |
author_facet |
Bisballe-Müller, Nina Chang, Anne B. Plumb, Erin J. Oguoma, Victor M. Halken, Susanne McCallum, Gabrielle B. |
author_sort |
Bisballe-Müller, Nina |
title |
Can Acute Cough Characteristics From Sound Recordings Differentiate Common Respiratory Illnesses in Children?:A Comparative Prospective Study |
title_short |
Can Acute Cough Characteristics From Sound Recordings Differentiate Common Respiratory Illnesses in Children?:A Comparative Prospective Study |
title_full |
Can Acute Cough Characteristics From Sound Recordings Differentiate Common Respiratory Illnesses in Children?:A Comparative Prospective Study |
title_fullStr |
Can Acute Cough Characteristics From Sound Recordings Differentiate Common Respiratory Illnesses in Children?:A Comparative Prospective Study |
title_full_unstemmed |
Can Acute Cough Characteristics From Sound Recordings Differentiate Common Respiratory Illnesses in Children?:A Comparative Prospective Study |
title_sort |
can acute cough characteristics from sound recordings differentiate common respiratory illnesses in children?:a comparative prospective study |
publishDate |
2021 |
url |
https://portal.findresearcher.sdu.dk/da/publications/b1473a67-01de-4fe3-822e-5bc3eedec230 https://doi.org/10.1016/j.chest.2020.06.067 |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Bisballe-Müller , N , Chang , A B , Plumb , E J , Oguoma , V M , Halken , S & McCallum , G B 2021 , ' Can Acute Cough Characteristics From Sound Recordings Differentiate Common Respiratory Illnesses in Children? A Comparative Prospective Study ' , Chest , vol. 159 , no. 1 , pp. 259-269 . https://doi.org/10.1016/j.chest.2020.06.067 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.chest.2020.06.067 |
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Chest |
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159 |
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259 |
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269 |
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