Association between genes on chromosome 19p13.2 and panic disorder
Panic disorder (PD) is a severe and disabling mental disorder, which is moderately heritable. In a previous study, we carried out a genome-wide association study using patients with PD and control individuals from the isolated population of the Faroe Islands and identified chromosome 19p13.2 as a ca...
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ftsydanskunivpub:oai:sdu.dk:publications/9d003684-3508-465e-b144-c1bdc7b868f3 2023-05-15T16:10:41+02:00 Association between genes on chromosome 19p13.2 and panic disorder Gregersen, Noomi O Buttenschøn, Henriette Nørmølle Hedemand, Anne Nielsen, Marit Nyholm Dahl, Hans A Kristensen, Ann Suhl Johansen, Oddbjørg Woldbye, David Pd Erhardt, Angelika Kruse, Torben A Wang, August G Børglum, Anders D. Mors, Ole 2016 https://portal.findresearcher.sdu.dk/da/publications/9d003684-3508-465e-b144-c1bdc7b868f3 https://doi.org/10.1097/YPG.0000000000000147 eng eng info:eu-repo/semantics/closedAccess Gregersen , N O , Buttenschøn , H N , Hedemand , A , Nielsen , M N , Dahl , H A , Kristensen , A S , Johansen , O , Woldbye , D P , Erhardt , A , Kruse , T A , Wang , A G , Børglum , A D & Mors , O 2016 , ' Association between genes on chromosome 19p13.2 and panic disorder ' , Psychiatric Genetics , vol. 26 , no. 6 , pp. 287-292 . https://doi.org/10.1097/YPG.0000000000000147 article 2016 ftsydanskunivpub https://doi.org/10.1097/YPG.0000000000000147 2022-08-14T09:34:56Z Panic disorder (PD) is a severe and disabling mental disorder, which is moderately heritable. In a previous study, we carried out a genome-wide association study using patients with PD and control individuals from the isolated population of the Faroe Islands and identified chromosome 19p13.2 as a candidate region. To further investigate this chromosomal region for association with PD, we analysed eight single nucleotide polymorphisms (SNPs) in three candidate genes - small-nuclear RNA activating complex, polypeptide 2 (SNAPC2), mitogen-activated protein kinase kinase 7 (MAP2K7) and leucine-rich repeat containing 8 family, member E (LRRC8E) - these genes have previously been directly or indirectly implicated in other mental disorders. A total of 511 patients with PD and 1029 healthy control individuals from the Faroe Islands, Denmark and Germany were included in the current study. SNPs covering the gene region of SNAPC2, MAP2K7 and LRRC8E were genotyped and tested for association with PD. In the Faroese cohort, rs7788 within SNAPC2 was significantly associated with PD, whereas rs3745383 within LRRC8E was nominally associated. No association was observed between the analysed SNPs and PD in the Danish cohorts. In the German women, we observed a nominal association between rs4804833 within MAP2K7 and PD. We present further evidence that chromosome 19p13.2 may harbour candidate genes that contribute towards the risk of developing PD. Moreover, the implication of the associated genes in other mental disorders may indicate shared genetic susceptibility between mental disorders. We show that associated variants may be sex specific, indicating the importance of carrying out a sex-specific association analysis of PD. Article in Journal/Newspaper Faroe Islands University of Southern Denmark Research Portal Faroe Islands Psychiatric Genetics 26 6 287 292 |
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University of Southern Denmark Research Portal |
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ftsydanskunivpub |
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English |
description |
Panic disorder (PD) is a severe and disabling mental disorder, which is moderately heritable. In a previous study, we carried out a genome-wide association study using patients with PD and control individuals from the isolated population of the Faroe Islands and identified chromosome 19p13.2 as a candidate region. To further investigate this chromosomal region for association with PD, we analysed eight single nucleotide polymorphisms (SNPs) in three candidate genes - small-nuclear RNA activating complex, polypeptide 2 (SNAPC2), mitogen-activated protein kinase kinase 7 (MAP2K7) and leucine-rich repeat containing 8 family, member E (LRRC8E) - these genes have previously been directly or indirectly implicated in other mental disorders. A total of 511 patients with PD and 1029 healthy control individuals from the Faroe Islands, Denmark and Germany were included in the current study. SNPs covering the gene region of SNAPC2, MAP2K7 and LRRC8E were genotyped and tested for association with PD. In the Faroese cohort, rs7788 within SNAPC2 was significantly associated with PD, whereas rs3745383 within LRRC8E was nominally associated. No association was observed between the analysed SNPs and PD in the Danish cohorts. In the German women, we observed a nominal association between rs4804833 within MAP2K7 and PD. We present further evidence that chromosome 19p13.2 may harbour candidate genes that contribute towards the risk of developing PD. Moreover, the implication of the associated genes in other mental disorders may indicate shared genetic susceptibility between mental disorders. We show that associated variants may be sex specific, indicating the importance of carrying out a sex-specific association analysis of PD. |
format |
Article in Journal/Newspaper |
author |
Gregersen, Noomi O Buttenschøn, Henriette Nørmølle Hedemand, Anne Nielsen, Marit Nyholm Dahl, Hans A Kristensen, Ann Suhl Johansen, Oddbjørg Woldbye, David Pd Erhardt, Angelika Kruse, Torben A Wang, August G Børglum, Anders D. Mors, Ole |
spellingShingle |
Gregersen, Noomi O Buttenschøn, Henriette Nørmølle Hedemand, Anne Nielsen, Marit Nyholm Dahl, Hans A Kristensen, Ann Suhl Johansen, Oddbjørg Woldbye, David Pd Erhardt, Angelika Kruse, Torben A Wang, August G Børglum, Anders D. Mors, Ole Association between genes on chromosome 19p13.2 and panic disorder |
author_facet |
Gregersen, Noomi O Buttenschøn, Henriette Nørmølle Hedemand, Anne Nielsen, Marit Nyholm Dahl, Hans A Kristensen, Ann Suhl Johansen, Oddbjørg Woldbye, David Pd Erhardt, Angelika Kruse, Torben A Wang, August G Børglum, Anders D. Mors, Ole |
author_sort |
Gregersen, Noomi O |
title |
Association between genes on chromosome 19p13.2 and panic disorder |
title_short |
Association between genes on chromosome 19p13.2 and panic disorder |
title_full |
Association between genes on chromosome 19p13.2 and panic disorder |
title_fullStr |
Association between genes on chromosome 19p13.2 and panic disorder |
title_full_unstemmed |
Association between genes on chromosome 19p13.2 and panic disorder |
title_sort |
association between genes on chromosome 19p13.2 and panic disorder |
publishDate |
2016 |
url |
https://portal.findresearcher.sdu.dk/da/publications/9d003684-3508-465e-b144-c1bdc7b868f3 https://doi.org/10.1097/YPG.0000000000000147 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Gregersen , N O , Buttenschøn , H N , Hedemand , A , Nielsen , M N , Dahl , H A , Kristensen , A S , Johansen , O , Woldbye , D P , Erhardt , A , Kruse , T A , Wang , A G , Børglum , A D & Mors , O 2016 , ' Association between genes on chromosome 19p13.2 and panic disorder ' , Psychiatric Genetics , vol. 26 , no. 6 , pp. 287-292 . https://doi.org/10.1097/YPG.0000000000000147 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1097/YPG.0000000000000147 |
container_title |
Psychiatric Genetics |
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26 |
container_issue |
6 |
container_start_page |
287 |
op_container_end_page |
292 |
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1765995843603660800 |