Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome
Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental...
Published in: | Environmental Science & Technology |
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2022
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Online Access: | https://portal.findresearcher.sdu.dk/da/publications/927b424e-85ef-40f7-9929-a68d014a3e3b https://doi.org/10.1021/acs.est.2c03185 |
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ftsydanskunivpub:oai:sdu.dk:publications/927b424e-85ef-40f7-9929-a68d014a3e3b 2024-09-09T19:39:55+00:00 Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome Thompson, Kelsey N. Oulhote, Youssef Weihe, Pal Wilkinson, Jeremy E. Ma, Siyuan Zhong, Huanzi Li, Junhua Kristiansen, Karsten Huttenhower, Curtis Grandjean, Philippe 2022-12-06 https://portal.findresearcher.sdu.dk/da/publications/927b424e-85ef-40f7-9929-a68d014a3e3b https://doi.org/10.1021/acs.est.2c03185 eng eng https://portal.findresearcher.sdu.dk/da/publications/927b424e-85ef-40f7-9929-a68d014a3e3b info:eu-repo/semantics/closedAccess Thompson , K N , Oulhote , Y , Weihe , P , Wilkinson , J E , Ma , S , Zhong , H , Li , J , Kristiansen , K , Huttenhower , C & Grandjean , P 2022 , ' Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome ' , Environmental Science & Technology , vol. 56 , no. 23 , pp. 16985-16995 . https://doi.org/10.1021/acs.est.2c03185 early life exposure gut microbiome article 2022 ftsydanskunivpub https://doi.org/10.1021/acs.est.2c03185 2024-08-05T23:48:16Z Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental chemicals, across multiple time points, with the composition of the adult gut microbiome. Here we studied 124 individuals born in the Faroe Islands in 1986-1987 who were followed approximately every seven years from birth through age 28 years. Organochlorine compounds, including polychlorinated biphenyls (PCBs) and pesticides, perfluoroalkyl substances (PFAS), and mercury (Hg), were measured in cord blood and longitudinally in participants' blood. At age 28, the gut microbiome was assessed using shotgun metagenomic sequencing. Historical contaminant exposures had little direct effect on the adult gut microbiome, while a small number of fastidious anaerobes were weakly linked to recent PFAS/PFOS exposures at age 28. In this cohort, our findings suggest no lasting effects of early life exposures on adult gut microbial composition, but proximal exposures may contribute to gut microbiome alterations. The methods developed and used for this investigation may help in future identification of small but lasting impacts of environmental toxicant exposure on the gut microbiome. Article in Journal/Newspaper Faroe Islands University of Southern Denmark Research Portal Faroe Islands Environmental Science & Technology 56 23 16985 16995 |
institution |
Open Polar |
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University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
early life exposure gut microbiome |
spellingShingle |
early life exposure gut microbiome Thompson, Kelsey N. Oulhote, Youssef Weihe, Pal Wilkinson, Jeremy E. Ma, Siyuan Zhong, Huanzi Li, Junhua Kristiansen, Karsten Huttenhower, Curtis Grandjean, Philippe Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome |
topic_facet |
early life exposure gut microbiome |
description |
Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental chemicals, across multiple time points, with the composition of the adult gut microbiome. Here we studied 124 individuals born in the Faroe Islands in 1986-1987 who were followed approximately every seven years from birth through age 28 years. Organochlorine compounds, including polychlorinated biphenyls (PCBs) and pesticides, perfluoroalkyl substances (PFAS), and mercury (Hg), were measured in cord blood and longitudinally in participants' blood. At age 28, the gut microbiome was assessed using shotgun metagenomic sequencing. Historical contaminant exposures had little direct effect on the adult gut microbiome, while a small number of fastidious anaerobes were weakly linked to recent PFAS/PFOS exposures at age 28. In this cohort, our findings suggest no lasting effects of early life exposures on adult gut microbial composition, but proximal exposures may contribute to gut microbiome alterations. The methods developed and used for this investigation may help in future identification of small but lasting impacts of environmental toxicant exposure on the gut microbiome. |
format |
Article in Journal/Newspaper |
author |
Thompson, Kelsey N. Oulhote, Youssef Weihe, Pal Wilkinson, Jeremy E. Ma, Siyuan Zhong, Huanzi Li, Junhua Kristiansen, Karsten Huttenhower, Curtis Grandjean, Philippe |
author_facet |
Thompson, Kelsey N. Oulhote, Youssef Weihe, Pal Wilkinson, Jeremy E. Ma, Siyuan Zhong, Huanzi Li, Junhua Kristiansen, Karsten Huttenhower, Curtis Grandjean, Philippe |
author_sort |
Thompson, Kelsey N. |
title |
Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome |
title_short |
Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome |
title_full |
Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome |
title_fullStr |
Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome |
title_full_unstemmed |
Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome |
title_sort |
effects of lifetime exposures to environmental contaminants on the adult gut microbiome |
publishDate |
2022 |
url |
https://portal.findresearcher.sdu.dk/da/publications/927b424e-85ef-40f7-9929-a68d014a3e3b https://doi.org/10.1021/acs.est.2c03185 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Thompson , K N , Oulhote , Y , Weihe , P , Wilkinson , J E , Ma , S , Zhong , H , Li , J , Kristiansen , K , Huttenhower , C & Grandjean , P 2022 , ' Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome ' , Environmental Science & Technology , vol. 56 , no. 23 , pp. 16985-16995 . https://doi.org/10.1021/acs.est.2c03185 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/927b424e-85ef-40f7-9929-a68d014a3e3b |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1021/acs.est.2c03185 |
container_title |
Environmental Science & Technology |
container_volume |
56 |
container_issue |
23 |
container_start_page |
16985 |
op_container_end_page |
16995 |
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1809908998455951360 |