Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS)
Semen quality may be adversely affected by exposure to environmental chemicals such as polychlorinated biphenyls (PCBs) and perfluorinated alkylate substances (PFASs) that are persistent and may act as endocrine disrupting compounds. The aim of this study was to explore whether PCBs or PFASs exposur...
Published in: | International Journal of Environmental Research and Public Health |
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Format: | Article in Journal/Newspaper |
Language: | English |
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2018
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Online Access: | https://portal.findresearcher.sdu.dk/da/publications/5966b630-3250-4413-84ac-f103e2635c35 https://doi.org/10.3390/ijerph15091880 https://findresearcher.sdu.dk/ws/files/146163182/Reproductive_Function_in_a_Population_of_Young_Faroese_Men_with_Elevated_Exposure_to_Polychlorinated_Biphenyls_PCBs_and_Perfluorinated_Alkylate_Substances_PFAS_.pdf |
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ftsydanskunivpub:oai:sdu.dk:publications/5966b630-3250-4413-84ac-f103e2635c35 2024-04-28T08:18:23+00:00 Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) Petersen, Maria Skaalum Halling, Jónrit Jørgensen, Niels Nielsen, Flemming Grandjean, Philippe Jensen, Tina Kold Weihe, Pál 2018-09-01 application/pdf https://portal.findresearcher.sdu.dk/da/publications/5966b630-3250-4413-84ac-f103e2635c35 https://doi.org/10.3390/ijerph15091880 https://findresearcher.sdu.dk/ws/files/146163182/Reproductive_Function_in_a_Population_of_Young_Faroese_Men_with_Elevated_Exposure_to_Polychlorinated_Biphenyls_PCBs_and_Perfluorinated_Alkylate_Substances_PFAS_.pdf eng eng https://portal.findresearcher.sdu.dk/da/publications/5966b630-3250-4413-84ac-f103e2635c35 info:eu-repo/semantics/openAccess Petersen , M S , Halling , J , Jørgensen , N , Nielsen , F , Grandjean , P , Jensen , T K & Weihe , P 2018 , ' Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) ' , International Journal of Environmental Research and Public Health , vol. 15 , no. 9 , 1880 . https://doi.org/10.3390/ijerph15091880 Endocrine disturbing compounds Faroe Islands Reproductive hormones Semen quality article 2018 ftsydanskunivpub https://doi.org/10.3390/ijerph15091880 2024-04-10T14:33:51Z Semen quality may be adversely affected by exposure to environmental chemicals such as polychlorinated biphenyls (PCBs) and perfluorinated alkylate substances (PFASs) that are persistent and may act as endocrine disrupting compounds. The aim of this study was to explore whether PCBs or PFASs exposure were associated with abnormalities in semen quality or reproductive hormones in Faroese men. This population based cross-sectional study includes 263 Faroese men (24⁻26 years) who delivered a semen sample for assessment of sperm concentration, total sperm count, semen volume, morphology and motility. A blood sample was drawn and analyzed for reproductive hormones, PCBs and PFASs. Exposure to ∑PCBs and perfluorooctane sulfonate (PFOS) was positively associated with sex hormone-binding globulin (SHBG) and luteinizing hormone (LH). In addition, total testosterone (T) was positively associated with ∑PCB. Both PCBs and PFOS appear to lead to increased SHBG, perhaps mediated via the liver. The higher total T associated with PCB may represent a compensatory adaption to elevated SHBG levels to maintain an unchanged free testosterone concentration. The positive association to LH for both PCBs and PFOS may indicate a direct adverse effect on the testosterone producing Leydig cells. Article in Journal/Newspaper Faroe Islands University of Southern Denmark Research Portal International Journal of Environmental Research and Public Health 15 9 1880 |
institution |
Open Polar |
collection |
University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
Endocrine disturbing compounds Faroe Islands Reproductive hormones Semen quality |
spellingShingle |
Endocrine disturbing compounds Faroe Islands Reproductive hormones Semen quality Petersen, Maria Skaalum Halling, Jónrit Jørgensen, Niels Nielsen, Flemming Grandjean, Philippe Jensen, Tina Kold Weihe, Pál Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) |
topic_facet |
Endocrine disturbing compounds Faroe Islands Reproductive hormones Semen quality |
description |
Semen quality may be adversely affected by exposure to environmental chemicals such as polychlorinated biphenyls (PCBs) and perfluorinated alkylate substances (PFASs) that are persistent and may act as endocrine disrupting compounds. The aim of this study was to explore whether PCBs or PFASs exposure were associated with abnormalities in semen quality or reproductive hormones in Faroese men. This population based cross-sectional study includes 263 Faroese men (24⁻26 years) who delivered a semen sample for assessment of sperm concentration, total sperm count, semen volume, morphology and motility. A blood sample was drawn and analyzed for reproductive hormones, PCBs and PFASs. Exposure to ∑PCBs and perfluorooctane sulfonate (PFOS) was positively associated with sex hormone-binding globulin (SHBG) and luteinizing hormone (LH). In addition, total testosterone (T) was positively associated with ∑PCB. Both PCBs and PFOS appear to lead to increased SHBG, perhaps mediated via the liver. The higher total T associated with PCB may represent a compensatory adaption to elevated SHBG levels to maintain an unchanged free testosterone concentration. The positive association to LH for both PCBs and PFOS may indicate a direct adverse effect on the testosterone producing Leydig cells. |
format |
Article in Journal/Newspaper |
author |
Petersen, Maria Skaalum Halling, Jónrit Jørgensen, Niels Nielsen, Flemming Grandjean, Philippe Jensen, Tina Kold Weihe, Pál |
author_facet |
Petersen, Maria Skaalum Halling, Jónrit Jørgensen, Niels Nielsen, Flemming Grandjean, Philippe Jensen, Tina Kold Weihe, Pál |
author_sort |
Petersen, Maria Skaalum |
title |
Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) |
title_short |
Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) |
title_full |
Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) |
title_fullStr |
Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) |
title_full_unstemmed |
Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) |
title_sort |
reproductive function in a population of young faroese men with elevated exposure to polychlorinated biphenyls (pcbs) and perfluorinated alkylate substances (pfas) |
publishDate |
2018 |
url |
https://portal.findresearcher.sdu.dk/da/publications/5966b630-3250-4413-84ac-f103e2635c35 https://doi.org/10.3390/ijerph15091880 https://findresearcher.sdu.dk/ws/files/146163182/Reproductive_Function_in_a_Population_of_Young_Faroese_Men_with_Elevated_Exposure_to_Polychlorinated_Biphenyls_PCBs_and_Perfluorinated_Alkylate_Substances_PFAS_.pdf |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Petersen , M S , Halling , J , Jørgensen , N , Nielsen , F , Grandjean , P , Jensen , T K & Weihe , P 2018 , ' Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS) ' , International Journal of Environmental Research and Public Health , vol. 15 , no. 9 , 1880 . https://doi.org/10.3390/ijerph15091880 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/5966b630-3250-4413-84ac-f103e2635c35 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/ijerph15091880 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
15 |
container_issue |
9 |
container_start_page |
1880 |
_version_ |
1797582422781460480 |