Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults:Age, Gene/Environment Susceptibility-Reykjavik Study
Many studies have examined the hypothesis that greater participation in physical activity (PA) is associated with less brain atrophy. Here we examine, in a sub-sample (n = 352, mean age 79.1 years) of the Age, Gene/Environment Susceptibility-Reykjavik Study cohort, the association of the baseline an...
Published in: | Behavioural Brain Research |
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Main Authors: | , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2016
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Subjects: | |
Online Access: | https://portal.findresearcher.sdu.dk/da/publications/529b9a82-c570-4974-a17b-562fe2c99b09 https://doi.org/10.1016/j.bbr.2015.09.005 |
Summary: | Many studies have examined the hypothesis that greater participation in physical activity (PA) is associated with less brain atrophy. Here we examine, in a sub-sample (n = 352, mean age 79.1 years) of the Age, Gene/Environment Susceptibility-Reykjavik Study cohort, the association of the baseline and 5-year change in magnetic resonance imaging (MRI)-derived volumes of gray matter (GM) and white matter (WM) to active and sedentary behavior (SB) measured at the end of the 5-year period by a hip-worn accelerometer for seven consecutive days. More GM (β = 0.11; p = 0.044) and WM (β = 0.11; p = 0.030) at baseline was associated with more total physical activity (TPA). Also, when adjusting for baseline values, the 5-year change in GM (β = 0.14; p = 0.0037) and WM (β = 0.11; p = 0.030) was associated with TPA. The 5-year change in WM was associated with SB (β = -0.11; p = 0.0007). These data suggest that objectively measured PA and SB late in life are associated with current and prior cross-sectional measures of brain atrophy, and that change over time is associated with PA and SB in expected directions. |
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