Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies:Part B Adults
Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015–2020); Swiss HBM4EU study (2020); DIET-HBM Icela...
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2022
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Online Access: | https://portal.findresearcher.sdu.dk/da/publications/476ab944-f938-46c0-aaa6-985a008ec7ef https://doi.org/10.3390/toxics10100552 https://findresearcher.sdu.dk/ws/files/212280687/Open_Access_Version.pdf |
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ftsydanskunivpub:oai:sdu.dk:publications/476ab944-f938-46c0-aaa6-985a008ec7ef 2024-05-12T08:05:57+00:00 Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies:Part B Adults Buekers, Jurgen Remy, Sylvie Bessems, Jos Govarts, Eva Rambaud, Loïc Riou, Margaux Halldorsson, Thorhallur I. Ólafsdóttir, Kristin Probst-Hensch, Nicole Ammann, Priska Weber, Till Kolossa-Gehring, Marike Esteban-López, Marta Castaño, Argelia Andersen, Helle Raun Schoeters, Greet 2022-10 application/pdf https://portal.findresearcher.sdu.dk/da/publications/476ab944-f938-46c0-aaa6-985a008ec7ef https://doi.org/10.3390/toxics10100552 https://findresearcher.sdu.dk/ws/files/212280687/Open_Access_Version.pdf eng eng https://portal.findresearcher.sdu.dk/da/publications/476ab944-f938-46c0-aaa6-985a008ec7ef info:eu-repo/semantics/openAccess Buekers , J , Remy , S , Bessems , J , Govarts , E , Rambaud , L , Riou , M , Halldorsson , T I , Ólafsdóttir , K , Probst-Hensch , N , Ammann , P , Weber , T , Kolossa-Gehring , M , Esteban-López , M , Castaño , A , Andersen , H R & Schoeters , G 2022 , ' Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies : Part B Adults ' , Toxics , vol. 10 , no. 10 , 552 . https://doi.org/10.3390/toxics10100552 adults AMPA exposure glyphosate HBM HBM4EU article 2022 ftsydanskunivpub https://doi.org/10.3390/toxics10100552 2024-04-17T15:22:35Z Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015–2020); Swiss HBM4EU study (2020); DIET-HBM Iceland (2019–2020); ESTEBAN France (2014–2016)) were included representing Northern and Western Europe. Overall, median values were below the reported quantification limits (LOQs) (0.05–0.1 µg/L). The 95th percentiles (P95) ranged between 0.24 and 0.37 µg/L urine for Gly and between 0.21 and 0.38 µg/L for AMPA. Lower values were observed in adults compared to children. Indications exist for autonomous sources of AMPA in the environment. As for children, reversed dosimetry calculations based on HBM data in adults did not lead to exceedances of the ADI (proposed acceptable daily intake of EFSA for Gly 0.1 mg/kg bw/day based on histopathological findings in the salivary gland of rats) indicating no human health risks in the studied populations at the moment. However, the controversy on carcinogenicity, potential endocrine effects and the absence of a group ADI for Gly and AMPA induce uncertainty to the risk assessment. Exposure determinant analysis showed few significant associations. More data on specific subgroups, such as those occupationally exposed or living close to agricultural fields or with certain consumption patterns (vegetarian, vegan, organic food, high cereal consumer), are needed to evaluate major exposure sources. Article in Journal/Newspaper Iceland University of Southern Denmark Research Portal Toxics 10 10 552 |
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Open Polar |
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University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
adults AMPA exposure glyphosate HBM HBM4EU |
spellingShingle |
adults AMPA exposure glyphosate HBM HBM4EU Buekers, Jurgen Remy, Sylvie Bessems, Jos Govarts, Eva Rambaud, Loïc Riou, Margaux Halldorsson, Thorhallur I. Ólafsdóttir, Kristin Probst-Hensch, Nicole Ammann, Priska Weber, Till Kolossa-Gehring, Marike Esteban-López, Marta Castaño, Argelia Andersen, Helle Raun Schoeters, Greet Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies:Part B Adults |
topic_facet |
adults AMPA exposure glyphosate HBM HBM4EU |
description |
Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015–2020); Swiss HBM4EU study (2020); DIET-HBM Iceland (2019–2020); ESTEBAN France (2014–2016)) were included representing Northern and Western Europe. Overall, median values were below the reported quantification limits (LOQs) (0.05–0.1 µg/L). The 95th percentiles (P95) ranged between 0.24 and 0.37 µg/L urine for Gly and between 0.21 and 0.38 µg/L for AMPA. Lower values were observed in adults compared to children. Indications exist for autonomous sources of AMPA in the environment. As for children, reversed dosimetry calculations based on HBM data in adults did not lead to exceedances of the ADI (proposed acceptable daily intake of EFSA for Gly 0.1 mg/kg bw/day based on histopathological findings in the salivary gland of rats) indicating no human health risks in the studied populations at the moment. However, the controversy on carcinogenicity, potential endocrine effects and the absence of a group ADI for Gly and AMPA induce uncertainty to the risk assessment. Exposure determinant analysis showed few significant associations. More data on specific subgroups, such as those occupationally exposed or living close to agricultural fields or with certain consumption patterns (vegetarian, vegan, organic food, high cereal consumer), are needed to evaluate major exposure sources. |
format |
Article in Journal/Newspaper |
author |
Buekers, Jurgen Remy, Sylvie Bessems, Jos Govarts, Eva Rambaud, Loïc Riou, Margaux Halldorsson, Thorhallur I. Ólafsdóttir, Kristin Probst-Hensch, Nicole Ammann, Priska Weber, Till Kolossa-Gehring, Marike Esteban-López, Marta Castaño, Argelia Andersen, Helle Raun Schoeters, Greet |
author_facet |
Buekers, Jurgen Remy, Sylvie Bessems, Jos Govarts, Eva Rambaud, Loïc Riou, Margaux Halldorsson, Thorhallur I. Ólafsdóttir, Kristin Probst-Hensch, Nicole Ammann, Priska Weber, Till Kolossa-Gehring, Marike Esteban-López, Marta Castaño, Argelia Andersen, Helle Raun Schoeters, Greet |
author_sort |
Buekers, Jurgen |
title |
Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies:Part B Adults |
title_short |
Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies:Part B Adults |
title_full |
Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies:Part B Adults |
title_fullStr |
Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies:Part B Adults |
title_full_unstemmed |
Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies:Part B Adults |
title_sort |
glyphosate and ampa in human urine of hbm4eu-aligned studies:part b adults |
publishDate |
2022 |
url |
https://portal.findresearcher.sdu.dk/da/publications/476ab944-f938-46c0-aaa6-985a008ec7ef https://doi.org/10.3390/toxics10100552 https://findresearcher.sdu.dk/ws/files/212280687/Open_Access_Version.pdf |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Buekers , J , Remy , S , Bessems , J , Govarts , E , Rambaud , L , Riou , M , Halldorsson , T I , Ólafsdóttir , K , Probst-Hensch , N , Ammann , P , Weber , T , Kolossa-Gehring , M , Esteban-López , M , Castaño , A , Andersen , H R & Schoeters , G 2022 , ' Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies : Part B Adults ' , Toxics , vol. 10 , no. 10 , 552 . https://doi.org/10.3390/toxics10100552 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/476ab944-f938-46c0-aaa6-985a008ec7ef |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/toxics10100552 |
container_title |
Toxics |
container_volume |
10 |
container_issue |
10 |
container_start_page |
552 |
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1798848344847548416 |