An ignored risk factor in toxicology:The total imprecision of exposure assessment
Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of prenatal methylmercury exposure, mercury concentrations were...
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ftsydanskunivpub:oai:sdu.dk:publications/471f6f16-62af-4207-a5b3-aa7ce41f758f 2024-05-19T07:40:02+00:00 An ignored risk factor in toxicology:The total imprecision of exposure assessment Grandjean, Philippe Budtz-Jørgensen, Esben 2010-01-25 https://portal.findresearcher.sdu.dk/da/publications/471f6f16-62af-4207-a5b3-aa7ce41f758f https://doi.org/10.1351/PAC-CON-09-05-04 eng eng https://portal.findresearcher.sdu.dk/da/publications/471f6f16-62af-4207-a5b3-aa7ce41f758f info:eu-repo/semantics/restrictedAccess Grandjean , P & Budtz-Jørgensen , E 2010 , ' An ignored risk factor in toxicology : The total imprecision of exposure assessment ' , Pure and Applied Chemistry , vol. 82 , no. 2 , pp. 383-391 . https://doi.org/10.1351/PAC-CON-09-05-04 article 2010 ftsydanskunivpub https://doi.org/10.1351/PAC-CON-09-05-04 2024-05-01T00:16:00Z Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of prenatal methylmercury exposure, mercury concentrations were determined in cord blood, cord tissue, and maternal hair. We determined their mutual correlations and their associations with the child's neurobehavioral effect variables at age 7 years. The exposure biomarkers correlated well with one another, but the cord blood mercury concentration showed the best associations with neurobehavioral deficits. Because at least three exposure parameters were available, factor analysis and structural equation modeling could be applied to determine the total imprecision of each biomarker. For the cord-blood parameter, the total imprecision was 25-30%, and almost twice as much for maternal hair. The total imprecision of these biomarkers much exceeded the normal laboratory variability of less than 5%. Such imprecision can cause underestimation of dose-related toxicity, and data analysis should therefore include sensitivity analyses that take this factor into account. Ignoring preanalytical imprecision may cause serious bias. Article in Journal/Newspaper Faroe Islands University of Southern Denmark Research Portal Pure and Applied Chemistry 82 2 383 391 |
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Open Polar |
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University of Southern Denmark Research Portal |
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ftsydanskunivpub |
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English |
description |
Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of prenatal methylmercury exposure, mercury concentrations were determined in cord blood, cord tissue, and maternal hair. We determined their mutual correlations and their associations with the child's neurobehavioral effect variables at age 7 years. The exposure biomarkers correlated well with one another, but the cord blood mercury concentration showed the best associations with neurobehavioral deficits. Because at least three exposure parameters were available, factor analysis and structural equation modeling could be applied to determine the total imprecision of each biomarker. For the cord-blood parameter, the total imprecision was 25-30%, and almost twice as much for maternal hair. The total imprecision of these biomarkers much exceeded the normal laboratory variability of less than 5%. Such imprecision can cause underestimation of dose-related toxicity, and data analysis should therefore include sensitivity analyses that take this factor into account. Ignoring preanalytical imprecision may cause serious bias. |
format |
Article in Journal/Newspaper |
author |
Grandjean, Philippe Budtz-Jørgensen, Esben |
spellingShingle |
Grandjean, Philippe Budtz-Jørgensen, Esben An ignored risk factor in toxicology:The total imprecision of exposure assessment |
author_facet |
Grandjean, Philippe Budtz-Jørgensen, Esben |
author_sort |
Grandjean, Philippe |
title |
An ignored risk factor in toxicology:The total imprecision of exposure assessment |
title_short |
An ignored risk factor in toxicology:The total imprecision of exposure assessment |
title_full |
An ignored risk factor in toxicology:The total imprecision of exposure assessment |
title_fullStr |
An ignored risk factor in toxicology:The total imprecision of exposure assessment |
title_full_unstemmed |
An ignored risk factor in toxicology:The total imprecision of exposure assessment |
title_sort |
ignored risk factor in toxicology:the total imprecision of exposure assessment |
publishDate |
2010 |
url |
https://portal.findresearcher.sdu.dk/da/publications/471f6f16-62af-4207-a5b3-aa7ce41f758f https://doi.org/10.1351/PAC-CON-09-05-04 |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Grandjean , P & Budtz-Jørgensen , E 2010 , ' An ignored risk factor in toxicology : The total imprecision of exposure assessment ' , Pure and Applied Chemistry , vol. 82 , no. 2 , pp. 383-391 . https://doi.org/10.1351/PAC-CON-09-05-04 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/471f6f16-62af-4207-a5b3-aa7ce41f758f |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1351/PAC-CON-09-05-04 |
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Pure and Applied Chemistry |
container_volume |
82 |
container_issue |
2 |
container_start_page |
383 |
op_container_end_page |
391 |
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1799479618596503552 |