Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring:A Faroese cohort study
Exposure to perfluoroalkyl substances (PFASs) has in some studies been associated with reduced anogenital distance (AGD) in newborns as a sensitive indicator of prenatal anti-androgenic exposure. The aim of this study was to investigate the association between maternal PFAS exposure and offspring AG...
Published in: | Reproductive Toxicology |
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2021
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ftsydanskunivpub:oai:sdu.dk:publications/351a2492-ac66-47d3-86f0-b425984a1005 2024-09-15T18:05:37+00:00 Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring:A Faroese cohort study Christensen, Jonathan Vibe Retbøll Bangash, Khushal Khan Weihe, Pál Grandjean, Phillippe Nielsen, Flemming Jensen, Tina Kold Petersen, Maria Skaalum 2021-09 application/pdf https://portal.findresearcher.sdu.dk/da/publications/351a2492-ac66-47d3-86f0-b425984a1005 https://doi.org/10.1016/j.reprotox.2021.06.016 https://findresearcher.sdu.dk/ws/files/192805549/TilReprodtox_27.05.2021_clean_rev.pdf eng eng https://portal.findresearcher.sdu.dk/da/publications/351a2492-ac66-47d3-86f0-b425984a1005 info:eu-repo/semantics/openAccess Christensen , J V R , Bangash , K K , Weihe , P , Grandjean , P , Nielsen , F , Jensen , T K & Petersen , M S 2021 , ' Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring : A Faroese cohort study ' , Reproductive Toxicology , vol. 104 , pp. 52-57 . https://doi.org/10.1016/j.reprotox.2021.06.016 Anogenital distance Faroe Islands Perfluorinated compounds PFAS Prenatal exposure article 2021 ftsydanskunivpub https://doi.org/10.1016/j.reprotox.2021.06.016 2024-08-05T23:48:16Z Exposure to perfluoroalkyl substances (PFASs) has in some studies been associated with reduced anogenital distance (AGD) in newborns as a sensitive indicator of prenatal anti-androgenic exposure. The aim of this study was to investigate the association between maternal PFAS exposure and offspring AGD in a population with wide ranges of PFAS exposures. Participants were recruited in the Faroe Islands in 2007–2009, and information on AGD and PFAS exposure was obtained from 463 mother-infant pairs. Perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) were measured in maternal serum. Data were analyzed using multiple linear regression analysis adjusted for birth weight, child age at examination, parity, and maternal education level. Among boys, higher maternal serum concentrations of PFOA, PFOS, PFNA and PFDA were significantly associated with a longer AGD, both with the exposure entered as a continuous variable and as quartiles. Boys in the highest quartile of PFOA, PFOS, PFNA and PFDA exposure had an increase in AGD of 1.2 mm (95 % CI 0.1;2.2), 1.3 mm (95 % CI 0.3;2.3), 1.0 mm (95 % CI 0.0:2.0) and 1.3 mm (95 % CI 0.3;2.4), respectively, when compared to boys in the lowest quartile of exposure (p < 0.05). No significant association was found between male AGD and PFHxS. No association was found for girls. In conclusion, elevated maternal exposure to major PFASs was significantly associated with a longer AGD in boys. No significant associations were found among girls, thus suggesting a sex-dimorphic effect of PFAS exposure. Article in Journal/Newspaper Faroe Islands University of Southern Denmark Research Portal Reproductive Toxicology 104 52 57 |
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Open Polar |
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University of Southern Denmark Research Portal |
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ftsydanskunivpub |
language |
English |
topic |
Anogenital distance Faroe Islands Perfluorinated compounds PFAS Prenatal exposure |
spellingShingle |
Anogenital distance Faroe Islands Perfluorinated compounds PFAS Prenatal exposure Christensen, Jonathan Vibe Retbøll Bangash, Khushal Khan Weihe, Pál Grandjean, Phillippe Nielsen, Flemming Jensen, Tina Kold Petersen, Maria Skaalum Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring:A Faroese cohort study |
topic_facet |
Anogenital distance Faroe Islands Perfluorinated compounds PFAS Prenatal exposure |
description |
Exposure to perfluoroalkyl substances (PFASs) has in some studies been associated with reduced anogenital distance (AGD) in newborns as a sensitive indicator of prenatal anti-androgenic exposure. The aim of this study was to investigate the association between maternal PFAS exposure and offspring AGD in a population with wide ranges of PFAS exposures. Participants were recruited in the Faroe Islands in 2007–2009, and information on AGD and PFAS exposure was obtained from 463 mother-infant pairs. Perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) were measured in maternal serum. Data were analyzed using multiple linear regression analysis adjusted for birth weight, child age at examination, parity, and maternal education level. Among boys, higher maternal serum concentrations of PFOA, PFOS, PFNA and PFDA were significantly associated with a longer AGD, both with the exposure entered as a continuous variable and as quartiles. Boys in the highest quartile of PFOA, PFOS, PFNA and PFDA exposure had an increase in AGD of 1.2 mm (95 % CI 0.1;2.2), 1.3 mm (95 % CI 0.3;2.3), 1.0 mm (95 % CI 0.0:2.0) and 1.3 mm (95 % CI 0.3;2.4), respectively, when compared to boys in the lowest quartile of exposure (p < 0.05). No significant association was found between male AGD and PFHxS. No association was found for girls. In conclusion, elevated maternal exposure to major PFASs was significantly associated with a longer AGD in boys. No significant associations were found among girls, thus suggesting a sex-dimorphic effect of PFAS exposure. |
format |
Article in Journal/Newspaper |
author |
Christensen, Jonathan Vibe Retbøll Bangash, Khushal Khan Weihe, Pál Grandjean, Phillippe Nielsen, Flemming Jensen, Tina Kold Petersen, Maria Skaalum |
author_facet |
Christensen, Jonathan Vibe Retbøll Bangash, Khushal Khan Weihe, Pál Grandjean, Phillippe Nielsen, Flemming Jensen, Tina Kold Petersen, Maria Skaalum |
author_sort |
Christensen, Jonathan Vibe Retbøll |
title |
Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring:A Faroese cohort study |
title_short |
Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring:A Faroese cohort study |
title_full |
Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring:A Faroese cohort study |
title_fullStr |
Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring:A Faroese cohort study |
title_full_unstemmed |
Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring:A Faroese cohort study |
title_sort |
maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring:a faroese cohort study |
publishDate |
2021 |
url |
https://portal.findresearcher.sdu.dk/da/publications/351a2492-ac66-47d3-86f0-b425984a1005 https://doi.org/10.1016/j.reprotox.2021.06.016 https://findresearcher.sdu.dk/ws/files/192805549/TilReprodtox_27.05.2021_clean_rev.pdf |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Christensen , J V R , Bangash , K K , Weihe , P , Grandjean , P , Nielsen , F , Jensen , T K & Petersen , M S 2021 , ' Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring : A Faroese cohort study ' , Reproductive Toxicology , vol. 104 , pp. 52-57 . https://doi.org/10.1016/j.reprotox.2021.06.016 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/351a2492-ac66-47d3-86f0-b425984a1005 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.reprotox.2021.06.016 |
container_title |
Reproductive Toxicology |
container_volume |
104 |
container_start_page |
52 |
op_container_end_page |
57 |
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1810443148288065536 |