Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury
This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective da...
Published in: | International Journal of Circumpolar Health |
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Online Access: | https://portal.findresearcher.sdu.dk/da/publications/30edb965-8451-49f9-bfb0-9d567bd57f51 https://doi.org/10.1080/22423982.2017.1406234 https://findresearcher.sdu.dk/ws/files/135356330/Secondary_sex_ratio_in_relation_to_exposures_to_polychlorinated_biphenyls_dichlorodiphenyl_dichloroethylene_and_methylmercury.pdf |
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ftsydanskunivpub:oai:sdu.dk:publications/30edb965-8451-49f9-bfb0-9d567bd57f51 2024-09-15T18:02:08+00:00 Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury Timmermann, Clara Amalie Gade Choi, Anna L Petersen, Maria Skaalum Nielsen, Flemming Budtz-Jørgensen, Esben Weihe, Pál Grandjean, Philippe 2017 application/pdf https://portal.findresearcher.sdu.dk/da/publications/30edb965-8451-49f9-bfb0-9d567bd57f51 https://doi.org/10.1080/22423982.2017.1406234 https://findresearcher.sdu.dk/ws/files/135356330/Secondary_sex_ratio_in_relation_to_exposures_to_polychlorinated_biphenyls_dichlorodiphenyl_dichloroethylene_and_methylmercury.pdf eng eng https://portal.findresearcher.sdu.dk/da/publications/30edb965-8451-49f9-bfb0-9d567bd57f51 info:eu-repo/semantics/openAccess Timmermann , C A G , Choi , A L , Petersen , M S , Nielsen , F , Budtz-Jørgensen , E , Weihe , P & Grandjean , P 2017 , ' Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury ' , International Journal of Circumpolar Health , vol. 76 , no. 1 , 1406234 . https://doi.org/10.1080/22423982.2017.1406234 Journal Article article 2017 ftsydanskunivpub https://doi.org/10.1080/22423982.2017.1406234 2024-07-08T23:47:00Z This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother-child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Exposures were measured in maternal hair, serum or umbilical cord blood. Confounder adjusted logistic regression models were used to assess the associations between maternal exposures and the secondary sex ratio. A doubling in ΣPCB, p,p'-DDE and mercury concentrations were associated with increased odds by 8% (95% CI = 0-16%), 7% (95% CI = 0-14%) and 9% (95% CI = 2-17%), respectively, of giving birth to a boy. In conclusion, maternal exposure to ΣPCB, DDE and methylmercury was associated with a slightly increased secondary sex ratio. The impact of paternal exposures could not be taken into account and deserves attention. Article in Journal/Newspaper Circumpolar Health Faroe Islands International Journal of Circumpolar Health Subarctic University of Southern Denmark Research Portal International Journal of Circumpolar Health 76 1 1406234 |
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University of Southern Denmark Research Portal |
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ftsydanskunivpub |
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English |
topic |
Journal Article |
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Journal Article Timmermann, Clara Amalie Gade Choi, Anna L Petersen, Maria Skaalum Nielsen, Flemming Budtz-Jørgensen, Esben Weihe, Pál Grandjean, Philippe Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
topic_facet |
Journal Article |
description |
This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother-child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Exposures were measured in maternal hair, serum or umbilical cord blood. Confounder adjusted logistic regression models were used to assess the associations between maternal exposures and the secondary sex ratio. A doubling in ΣPCB, p,p'-DDE and mercury concentrations were associated with increased odds by 8% (95% CI = 0-16%), 7% (95% CI = 0-14%) and 9% (95% CI = 2-17%), respectively, of giving birth to a boy. In conclusion, maternal exposure to ΣPCB, DDE and methylmercury was associated with a slightly increased secondary sex ratio. The impact of paternal exposures could not be taken into account and deserves attention. |
format |
Article in Journal/Newspaper |
author |
Timmermann, Clara Amalie Gade Choi, Anna L Petersen, Maria Skaalum Nielsen, Flemming Budtz-Jørgensen, Esben Weihe, Pál Grandjean, Philippe |
author_facet |
Timmermann, Clara Amalie Gade Choi, Anna L Petersen, Maria Skaalum Nielsen, Flemming Budtz-Jørgensen, Esben Weihe, Pál Grandjean, Philippe |
author_sort |
Timmermann, Clara Amalie Gade |
title |
Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
title_short |
Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
title_full |
Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
title_fullStr |
Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
title_full_unstemmed |
Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
title_sort |
secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
publishDate |
2017 |
url |
https://portal.findresearcher.sdu.dk/da/publications/30edb965-8451-49f9-bfb0-9d567bd57f51 https://doi.org/10.1080/22423982.2017.1406234 https://findresearcher.sdu.dk/ws/files/135356330/Secondary_sex_ratio_in_relation_to_exposures_to_polychlorinated_biphenyls_dichlorodiphenyl_dichloroethylene_and_methylmercury.pdf |
genre |
Circumpolar Health Faroe Islands International Journal of Circumpolar Health Subarctic |
genre_facet |
Circumpolar Health Faroe Islands International Journal of Circumpolar Health Subarctic |
op_source |
Timmermann , C A G , Choi , A L , Petersen , M S , Nielsen , F , Budtz-Jørgensen , E , Weihe , P & Grandjean , P 2017 , ' Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury ' , International Journal of Circumpolar Health , vol. 76 , no. 1 , 1406234 . https://doi.org/10.1080/22423982.2017.1406234 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/30edb965-8451-49f9-bfb0-9d567bd57f51 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1080/22423982.2017.1406234 |
container_title |
International Journal of Circumpolar Health |
container_volume |
76 |
container_issue |
1 |
container_start_page |
1406234 |
_version_ |
1810439395104260096 |