Cardiovascular risk factors associated with age-related macular degeneration:The Tromsø Study
PurposeTo examine associations between cardiovascular risk factors and age-related macular degeneration (AMD). MethodsA population-based, cross-sectional study of Caucasians aged 65-87years was conducted in Norway in 2007/2008. Retinal photographs were graded for AMD. Multivariable logistic regressi...
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2014
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Online Access: | https://portal.findresearcher.sdu.dk/da/publications/2672f753-d0ef-4044-9344-7dfc6eb44f4e https://doi.org/10.1111/aos.12346 |
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ftsydanskunivpub:oai:sdu.dk:publications/2672f753-d0ef-4044-9344-7dfc6eb44f4e 2024-06-23T07:50:55+00:00 Cardiovascular risk factors associated with age-related macular degeneration:The Tromsø Study Erke, M. G. Bertelsen, G. Peto, T. Sjolie, A. K. Lindekleiv, H. Njolstad, I. 2014-11 https://portal.findresearcher.sdu.dk/da/publications/2672f753-d0ef-4044-9344-7dfc6eb44f4e https://doi.org/10.1111/aos.12346 eng eng https://portal.findresearcher.sdu.dk/da/publications/2672f753-d0ef-4044-9344-7dfc6eb44f4e info:eu-repo/semantics/restrictedAccess Erke , M G , Bertelsen , G , Peto , T , Sjolie , A K , Lindekleiv , H & Njolstad , I 2014 , ' Cardiovascular risk factors associated with age-related macular degeneration : The Tromsø Study ' , Acta Ophthalmologica , vol. 92 , no. 7 , pp. 662-669 . https://doi.org/10.1111/aos.12346 age-related macular degeneration body mass index epidemiology hypertension physical activity risk factors sex difference smoking Overweight/complications Prospective Studies Humans Middle Aged Hypertension/complications Male Smoking/adverse effects Aged 80 and over Female Surveys and Questionnaires Alcohol Drinking/adverse effects Cross-Sectional Studies Cardiovascular Diseases/epidemiology Norway/epidemiology Arctic Regions Obesity/complications Macular Degeneration/epidemiology Sedentary Behavior article 2014 ftsydanskunivpub https://doi.org/10.1111/aos.12346 2024-06-11T14:20:39Z PurposeTo examine associations between cardiovascular risk factors and age-related macular degeneration (AMD). MethodsA population-based, cross-sectional study of Caucasians aged 65-87years was conducted in Norway in 2007/2008. Retinal photographs were graded for AMD. Multivariable logistic regression analyses were performed based on questionnaires addressing habits of smoking, alcohol consumption, physical activity, health and medication; and physical examination comprising anthropometric measurements, blood pressure and blood sampling. Cardiovascular disease status was obtained from a validated end-point registry. ResultsGradable photographs were available for 2631 participants, of whom 92 (3.5%) subjects had late AMD. In the multivariable analysis of late AMD, significant interactions were found between sex and the variables age, triglyceride level, use of lipid-lowering drugs and physical exercise. Current daily smoking was significantly related to late AMD in both sexes (odds ratio (OR) 4.06, 95% confidence interval (CI) 1.69-9.76 and OR 3.59, 95% CI 1.17-11.04, women and men, respectively) compared with never smokers. Higher number of pack years was associated with the presence of large drusen (>125m) (OR 1.04, 95% CI 1.01-1.09 per 5years). Higher systolic blood pressure (OR 1.06, 95% CI 1.01-1.12 per 5mmHg), overweight (OR 2.87, 95% CI 1.13-7.29) and obesity (OR 2.92, 95% CI 1.06-8.03), physical exercise duration (OR 0.41, 95% 0.18-0.96 for 30min or more compared with less) and frequency (OR 0.46, 95% CI 0.23-0.92 for weekly or more often compared to less) were associated with late AMD in women only. ConclusionsSmoking was strongly associated with AMD, in line with results from other populations. Also, late AMD was related to higher systolic blood pressure, physical inactivity, overweight and obesity in women. Purpose To examine associations between cardiovascular risk factors and age-related macular degeneration (AMD). Methods A population-based, cross-sectional study of Caucasians aged 65-87 years ... Article in Journal/Newspaper Arctic Tromsø University of Southern Denmark Research Portal Arctic Norway Tromsø Acta Ophthalmologica 92 7 662 669 |
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Open Polar |
collection |
University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
age-related macular degeneration body mass index epidemiology hypertension physical activity risk factors sex difference smoking Overweight/complications Prospective Studies Humans Middle Aged Hypertension/complications Male Smoking/adverse effects Aged 80 and over Female Surveys and Questionnaires Alcohol Drinking/adverse effects Cross-Sectional Studies Cardiovascular Diseases/epidemiology Norway/epidemiology Arctic Regions Obesity/complications Macular Degeneration/epidemiology Sedentary Behavior |
spellingShingle |
age-related macular degeneration body mass index epidemiology hypertension physical activity risk factors sex difference smoking Overweight/complications Prospective Studies Humans Middle Aged Hypertension/complications Male Smoking/adverse effects Aged 80 and over Female Surveys and Questionnaires Alcohol Drinking/adverse effects Cross-Sectional Studies Cardiovascular Diseases/epidemiology Norway/epidemiology Arctic Regions Obesity/complications Macular Degeneration/epidemiology Sedentary Behavior Erke, M. G. Bertelsen, G. Peto, T. Sjolie, A. K. Lindekleiv, H. Njolstad, I. Cardiovascular risk factors associated with age-related macular degeneration:The Tromsø Study |
topic_facet |
age-related macular degeneration body mass index epidemiology hypertension physical activity risk factors sex difference smoking Overweight/complications Prospective Studies Humans Middle Aged Hypertension/complications Male Smoking/adverse effects Aged 80 and over Female Surveys and Questionnaires Alcohol Drinking/adverse effects Cross-Sectional Studies Cardiovascular Diseases/epidemiology Norway/epidemiology Arctic Regions Obesity/complications Macular Degeneration/epidemiology Sedentary Behavior |
description |
PurposeTo examine associations between cardiovascular risk factors and age-related macular degeneration (AMD). MethodsA population-based, cross-sectional study of Caucasians aged 65-87years was conducted in Norway in 2007/2008. Retinal photographs were graded for AMD. Multivariable logistic regression analyses were performed based on questionnaires addressing habits of smoking, alcohol consumption, physical activity, health and medication; and physical examination comprising anthropometric measurements, blood pressure and blood sampling. Cardiovascular disease status was obtained from a validated end-point registry. ResultsGradable photographs were available for 2631 participants, of whom 92 (3.5%) subjects had late AMD. In the multivariable analysis of late AMD, significant interactions were found between sex and the variables age, triglyceride level, use of lipid-lowering drugs and physical exercise. Current daily smoking was significantly related to late AMD in both sexes (odds ratio (OR) 4.06, 95% confidence interval (CI) 1.69-9.76 and OR 3.59, 95% CI 1.17-11.04, women and men, respectively) compared with never smokers. Higher number of pack years was associated with the presence of large drusen (>125m) (OR 1.04, 95% CI 1.01-1.09 per 5years). Higher systolic blood pressure (OR 1.06, 95% CI 1.01-1.12 per 5mmHg), overweight (OR 2.87, 95% CI 1.13-7.29) and obesity (OR 2.92, 95% CI 1.06-8.03), physical exercise duration (OR 0.41, 95% 0.18-0.96 for 30min or more compared with less) and frequency (OR 0.46, 95% CI 0.23-0.92 for weekly or more often compared to less) were associated with late AMD in women only. ConclusionsSmoking was strongly associated with AMD, in line with results from other populations. Also, late AMD was related to higher systolic blood pressure, physical inactivity, overweight and obesity in women. Purpose To examine associations between cardiovascular risk factors and age-related macular degeneration (AMD). Methods A population-based, cross-sectional study of Caucasians aged 65-87 years ... |
format |
Article in Journal/Newspaper |
author |
Erke, M. G. Bertelsen, G. Peto, T. Sjolie, A. K. Lindekleiv, H. Njolstad, I. |
author_facet |
Erke, M. G. Bertelsen, G. Peto, T. Sjolie, A. K. Lindekleiv, H. Njolstad, I. |
author_sort |
Erke, M. G. |
title |
Cardiovascular risk factors associated with age-related macular degeneration:The Tromsø Study |
title_short |
Cardiovascular risk factors associated with age-related macular degeneration:The Tromsø Study |
title_full |
Cardiovascular risk factors associated with age-related macular degeneration:The Tromsø Study |
title_fullStr |
Cardiovascular risk factors associated with age-related macular degeneration:The Tromsø Study |
title_full_unstemmed |
Cardiovascular risk factors associated with age-related macular degeneration:The Tromsø Study |
title_sort |
cardiovascular risk factors associated with age-related macular degeneration:the tromsø study |
publishDate |
2014 |
url |
https://portal.findresearcher.sdu.dk/da/publications/2672f753-d0ef-4044-9344-7dfc6eb44f4e https://doi.org/10.1111/aos.12346 |
geographic |
Arctic Norway Tromsø |
geographic_facet |
Arctic Norway Tromsø |
genre |
Arctic Tromsø |
genre_facet |
Arctic Tromsø |
op_source |
Erke , M G , Bertelsen , G , Peto , T , Sjolie , A K , Lindekleiv , H & Njolstad , I 2014 , ' Cardiovascular risk factors associated with age-related macular degeneration : The Tromsø Study ' , Acta Ophthalmologica , vol. 92 , no. 7 , pp. 662-669 . https://doi.org/10.1111/aos.12346 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/2672f753-d0ef-4044-9344-7dfc6eb44f4e |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1111/aos.12346 |
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Acta Ophthalmologica |
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92 |
container_issue |
7 |
container_start_page |
662 |
op_container_end_page |
669 |
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