Retinal vascular calibres are significantly associated with cardiovascular risk factors:the Tromsø Eye Study
Purpose: To describe the association between retinal vascular calibres and cardiovascular risk factors. Methods: Population-based cross-sectional study including 6353 participants of the TromsO Eye Study in Norway aged 38-87years. Retinal arteriolar calibre (central retinal artery equivalent) and re...
Published in: | Acta Ophthalmologica |
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2014
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Online Access: | https://portal.findresearcher.sdu.dk/da/publications/1b6f88c4-6d2b-4105-8b52-b9b9a834f8be https://doi.org/10.1111/aos.12102 |
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ftsydanskunivpub:oai:sdu.dk:publications/1b6f88c4-6d2b-4105-8b52-b9b9a834f8be 2023-05-15T18:33:55+02:00 Retinal vascular calibres are significantly associated with cardiovascular risk factors:the Tromsø Eye Study von Hanno, T. Bertelsen, G. Sjølie, Anne K. Mathiesen, E. B. 2014-02 https://portal.findresearcher.sdu.dk/da/publications/1b6f88c4-6d2b-4105-8b52-b9b9a834f8be https://doi.org/10.1111/aos.12102 eng eng info:eu-repo/semantics/restrictedAccess von Hanno , T , Bertelsen , G , Sjølie , A K & Mathiesen , E B 2014 , ' Retinal vascular calibres are significantly associated with cardiovascular risk factors : the Tromsø Eye Study ' , Acta Ophthalmologica , vol. 92 , no. 1 , pp. 40-46 . https://doi.org/10.1111/aos.12102 Tromsø Eye Study cardiovascular risk factors cohort study epidemiology microcirculation retinal vascular calibre Humans Middle Aged Male Retinal Artery/pathology Aged 80 and over Adult Female Body Mass Index Blood Pressure/physiology Cholesterol LDL/blood Cross-Sectional Studies Retinal Vein/pathology Cardiovascular Diseases/epidemiology Norway/epidemiology Risk Factors Smoking/epidemiology HDL/blood Glycated Hemoglobin A/metabolism Cohort Studies article 2014 ftsydanskunivpub https://doi.org/10.1111/aos.12102 2022-08-14T09:12:57Z Purpose: To describe the association between retinal vascular calibres and cardiovascular risk factors. Methods: Population-based cross-sectional study including 6353 participants of the TromsO Eye Study in Norway aged 38-87years. Retinal arteriolar calibre (central retinal artery equivalent) and retinal venular calibre (central retinal vein equivalent) were measured computer-assisted on retinal photographs. Data on blood pressure, body mass index (BMI), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, glycosylated haemoglobin (HbA1c) and smoking were collected. Association between retinal vessel calibre and the cardiovascular risk factors was assessed by multivariable linear and logistic regression analyses. Results: Retinal arteriolar calibre was independently associated with age, blood pressure, HbA1c and smoking in women and men, and with HDL cholesterol in men only. Blood pressure had the strongest effect on arteriolar calibre, with a decrease in calibre of 3.6m (women)/4.1m (men) per standard deviation increase in mean arterial blood pressure. Retinal venular calibre was independently associated with age, blood pressure, BMI, HDL and LDL cholesterol and smoking in men and women. The effect of BMI and HDL cholesterol on venular calibre was significantly stronger in men than in women. Current smoking was the most important factor for venular calibre, where smokers had 13.2m (women)/15.2m (men) wider calibre than nonsmokers. Conclusion: All the explored cardiovascular risk factors were independently associated with retinal vascular calibre, with stronger effect of HDL cholesterol and BMI in men than in women. Blood pressure and smoking contributed most to the explained variance. Article in Journal/Newspaper Tromso Tromso Tromsø University of Southern Denmark Research Portal Norway Tromso ENVELOPE(16.546,16.546,68.801,68.801) Tromsø Acta Ophthalmologica 92 1 40 46 |
institution |
Open Polar |
collection |
University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
Tromsø Eye Study cardiovascular risk factors cohort study epidemiology microcirculation retinal vascular calibre Humans Middle Aged Male Retinal Artery/pathology Aged 80 and over Adult Female Body Mass Index Blood Pressure/physiology Cholesterol LDL/blood Cross-Sectional Studies Retinal Vein/pathology Cardiovascular Diseases/epidemiology Norway/epidemiology Risk Factors Smoking/epidemiology HDL/blood Glycated Hemoglobin A/metabolism Cohort Studies |
spellingShingle |
Tromsø Eye Study cardiovascular risk factors cohort study epidemiology microcirculation retinal vascular calibre Humans Middle Aged Male Retinal Artery/pathology Aged 80 and over Adult Female Body Mass Index Blood Pressure/physiology Cholesterol LDL/blood Cross-Sectional Studies Retinal Vein/pathology Cardiovascular Diseases/epidemiology Norway/epidemiology Risk Factors Smoking/epidemiology HDL/blood Glycated Hemoglobin A/metabolism Cohort Studies von Hanno, T. Bertelsen, G. Sjølie, Anne K. Mathiesen, E. B. Retinal vascular calibres are significantly associated with cardiovascular risk factors:the Tromsø Eye Study |
topic_facet |
Tromsø Eye Study cardiovascular risk factors cohort study epidemiology microcirculation retinal vascular calibre Humans Middle Aged Male Retinal Artery/pathology Aged 80 and over Adult Female Body Mass Index Blood Pressure/physiology Cholesterol LDL/blood Cross-Sectional Studies Retinal Vein/pathology Cardiovascular Diseases/epidemiology Norway/epidemiology Risk Factors Smoking/epidemiology HDL/blood Glycated Hemoglobin A/metabolism Cohort Studies |
description |
Purpose: To describe the association between retinal vascular calibres and cardiovascular risk factors. Methods: Population-based cross-sectional study including 6353 participants of the TromsO Eye Study in Norway aged 38-87years. Retinal arteriolar calibre (central retinal artery equivalent) and retinal venular calibre (central retinal vein equivalent) were measured computer-assisted on retinal photographs. Data on blood pressure, body mass index (BMI), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, glycosylated haemoglobin (HbA1c) and smoking were collected. Association between retinal vessel calibre and the cardiovascular risk factors was assessed by multivariable linear and logistic regression analyses. Results: Retinal arteriolar calibre was independently associated with age, blood pressure, HbA1c and smoking in women and men, and with HDL cholesterol in men only. Blood pressure had the strongest effect on arteriolar calibre, with a decrease in calibre of 3.6m (women)/4.1m (men) per standard deviation increase in mean arterial blood pressure. Retinal venular calibre was independently associated with age, blood pressure, BMI, HDL and LDL cholesterol and smoking in men and women. The effect of BMI and HDL cholesterol on venular calibre was significantly stronger in men than in women. Current smoking was the most important factor for venular calibre, where smokers had 13.2m (women)/15.2m (men) wider calibre than nonsmokers. Conclusion: All the explored cardiovascular risk factors were independently associated with retinal vascular calibre, with stronger effect of HDL cholesterol and BMI in men than in women. Blood pressure and smoking contributed most to the explained variance. |
format |
Article in Journal/Newspaper |
author |
von Hanno, T. Bertelsen, G. Sjølie, Anne K. Mathiesen, E. B. |
author_facet |
von Hanno, T. Bertelsen, G. Sjølie, Anne K. Mathiesen, E. B. |
author_sort |
von Hanno, T. |
title |
Retinal vascular calibres are significantly associated with cardiovascular risk factors:the Tromsø Eye Study |
title_short |
Retinal vascular calibres are significantly associated with cardiovascular risk factors:the Tromsø Eye Study |
title_full |
Retinal vascular calibres are significantly associated with cardiovascular risk factors:the Tromsø Eye Study |
title_fullStr |
Retinal vascular calibres are significantly associated with cardiovascular risk factors:the Tromsø Eye Study |
title_full_unstemmed |
Retinal vascular calibres are significantly associated with cardiovascular risk factors:the Tromsø Eye Study |
title_sort |
retinal vascular calibres are significantly associated with cardiovascular risk factors:the tromsø eye study |
publishDate |
2014 |
url |
https://portal.findresearcher.sdu.dk/da/publications/1b6f88c4-6d2b-4105-8b52-b9b9a834f8be https://doi.org/10.1111/aos.12102 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Norway Tromso Tromsø |
geographic_facet |
Norway Tromso Tromsø |
genre |
Tromso Tromso Tromsø |
genre_facet |
Tromso Tromso Tromsø |
op_source |
von Hanno , T , Bertelsen , G , Sjølie , A K & Mathiesen , E B 2014 , ' Retinal vascular calibres are significantly associated with cardiovascular risk factors : the Tromsø Eye Study ' , Acta Ophthalmologica , vol. 92 , no. 1 , pp. 40-46 . https://doi.org/10.1111/aos.12102 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1111/aos.12102 |
container_title |
Acta Ophthalmologica |
container_volume |
92 |
container_issue |
1 |
container_start_page |
40 |
op_container_end_page |
46 |
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1766218547003916288 |