DNA-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit--is there a relation with the low risk of cardiovascular disease in the Inuit?
Greenland Inuit are a population with a low risk of cardiovascular disease. Recently, we stated that frequencies of potentially high risk alleles of the apolipoproteins, fibrinogen, factor V, glycoprotein IIIa and factor VII (FVII) genes have different allele frequencies in the Inuit when compared w...
Published in: | Thrombosis and Haemostasis |
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Format: | Article in Journal/Newspaper |
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1999
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Online Access: | https://portal.findresearcher.sdu.dk/da/publications/1b3b68f0-ec1c-11dc-86ef-000ea68e967b https://doi.org/10.1055/s-0037-1614522 |
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ftsydanskunivpub:oai:sdu.dk:publications/1b3b68f0-ec1c-11dc-86ef-000ea68e967b 2024-05-12T08:04:28+00:00 DNA-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit--is there a relation with the low risk of cardiovascular disease in the Inuit? Maat, M de Bladbjerg, E-M Johansen, L G de Knijff, P Gram, J Kluft, C Jespersen, J 1999-04-01 https://portal.findresearcher.sdu.dk/da/publications/1b3b68f0-ec1c-11dc-86ef-000ea68e967b https://doi.org/10.1055/s-0037-1614522 eng eng https://portal.findresearcher.sdu.dk/da/publications/1b3b68f0-ec1c-11dc-86ef-000ea68e967b info:eu-repo/semantics/closedAccess Maat , M D , Bladbjerg , E-M , Johansen , L G , de Knijff , P , Gram , J , Kluft , C & Jespersen , J 1999 , ' DNA-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit--is there a relation with the low risk of cardiovascular disease in the Inuit? ' , Thrombosis and Haemostasis , vol. 81 , no. 4 , pp. 547-52 . https://doi.org/10.1055/s-0037-1614522 Adult Alleles Angiotensinogen Antifibrinolytic Agents Cardiovascular Diseases DNA Denmark Female Fibrin Fibrinogen Degradation Products Greenland Humans Inuits Male Polymorphism Genetic Risk Factors Vascular Diseases article 1999 ftsydanskunivpub https://doi.org/10.1055/s-0037-1614522 2024-04-17T14:53:28Z Greenland Inuit are a population with a low risk of cardiovascular disease. Recently, we stated that frequencies of potentially high risk alleles of the apolipoproteins, fibrinogen, factor V, glycoprotein IIIa and factor VII (FVII) genes have different allele frequencies in the Inuit when compared with Caucasian populations. We have extended this study and evaluated whether or not this was also true for the genetic polymorphisms of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), angiotensin-converting enzyme (ACE) and angiotensinogen in a group of 133 Greenland Inuit, aged 30-34 gamma. In addition, we compared the plasma levels of these factors and those of C-reactive protein (CRP) and D-Dimer in Inuit and in Danes, comparable for age and gender. Frequencies (f) were assessed of the alleles that are known as the potential high risk alleles in Caucasians. In the Inuit, the f(insertion allele) of the t-PA intron8ins311 polymorphism was 0.37 (CI 0.32-0.43), the f(4G allele) of the PAI-1 promoter polymorphism was 0.88 (CI 0.83-0.91), the f(deletion allele) of the ACE intron16ins287 polymorphism was 0.40 (CI 0.33-0.47) and the f(M-allele) of the angiotensinogen M/T353 polymorphism was 0.30(CI 0.25-0.38). As for fibrinogen and FVII polymorphisms, these frequencies are all significantly different from what is reported for Caucasian populations. In the Inuit, plasma levels of fibrinogen and D-Dimer were higher than in the Danes, the PAI-1 levels were lower and FVII, t-PA and CRP levels were comparable. The observed allele frequencies of the polymorphisms of t-PA, fibrinogen, FVII, ACE, angiotensinogen and the plasma levels of PAI-1 and D-Dimer were in accordance with the low CVD risk in the Inuit, considering the observed associations between these measures and CVD risk in Caucasian populations, but for other measures this was not the case (allele frequencies of the PAI-1 polymorphism, and plasma levels of fibrinogen, FVII and t-PA). In conclusion there are clear differences in ... Article in Journal/Newspaper Greenland inuit inuits University of Southern Denmark Research Portal Greenland Thrombosis and Haemostasis 81 04 547 552 |
institution |
Open Polar |
collection |
University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
Adult Alleles Angiotensinogen Antifibrinolytic Agents Cardiovascular Diseases DNA Denmark Female Fibrin Fibrinogen Degradation Products Greenland Humans Inuits Male Polymorphism Genetic Risk Factors Vascular Diseases |
spellingShingle |
Adult Alleles Angiotensinogen Antifibrinolytic Agents Cardiovascular Diseases DNA Denmark Female Fibrin Fibrinogen Degradation Products Greenland Humans Inuits Male Polymorphism Genetic Risk Factors Vascular Diseases Maat, M de Bladbjerg, E-M Johansen, L G de Knijff, P Gram, J Kluft, C Jespersen, J DNA-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit--is there a relation with the low risk of cardiovascular disease in the Inuit? |
topic_facet |
Adult Alleles Angiotensinogen Antifibrinolytic Agents Cardiovascular Diseases DNA Denmark Female Fibrin Fibrinogen Degradation Products Greenland Humans Inuits Male Polymorphism Genetic Risk Factors Vascular Diseases |
description |
Greenland Inuit are a population with a low risk of cardiovascular disease. Recently, we stated that frequencies of potentially high risk alleles of the apolipoproteins, fibrinogen, factor V, glycoprotein IIIa and factor VII (FVII) genes have different allele frequencies in the Inuit when compared with Caucasian populations. We have extended this study and evaluated whether or not this was also true for the genetic polymorphisms of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), angiotensin-converting enzyme (ACE) and angiotensinogen in a group of 133 Greenland Inuit, aged 30-34 gamma. In addition, we compared the plasma levels of these factors and those of C-reactive protein (CRP) and D-Dimer in Inuit and in Danes, comparable for age and gender. Frequencies (f) were assessed of the alleles that are known as the potential high risk alleles in Caucasians. In the Inuit, the f(insertion allele) of the t-PA intron8ins311 polymorphism was 0.37 (CI 0.32-0.43), the f(4G allele) of the PAI-1 promoter polymorphism was 0.88 (CI 0.83-0.91), the f(deletion allele) of the ACE intron16ins287 polymorphism was 0.40 (CI 0.33-0.47) and the f(M-allele) of the angiotensinogen M/T353 polymorphism was 0.30(CI 0.25-0.38). As for fibrinogen and FVII polymorphisms, these frequencies are all significantly different from what is reported for Caucasian populations. In the Inuit, plasma levels of fibrinogen and D-Dimer were higher than in the Danes, the PAI-1 levels were lower and FVII, t-PA and CRP levels were comparable. The observed allele frequencies of the polymorphisms of t-PA, fibrinogen, FVII, ACE, angiotensinogen and the plasma levels of PAI-1 and D-Dimer were in accordance with the low CVD risk in the Inuit, considering the observed associations between these measures and CVD risk in Caucasian populations, but for other measures this was not the case (allele frequencies of the PAI-1 polymorphism, and plasma levels of fibrinogen, FVII and t-PA). In conclusion there are clear differences in ... |
format |
Article in Journal/Newspaper |
author |
Maat, M de Bladbjerg, E-M Johansen, L G de Knijff, P Gram, J Kluft, C Jespersen, J |
author_facet |
Maat, M de Bladbjerg, E-M Johansen, L G de Knijff, P Gram, J Kluft, C Jespersen, J |
author_sort |
Maat, M de |
title |
DNA-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit--is there a relation with the low risk of cardiovascular disease in the Inuit? |
title_short |
DNA-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit--is there a relation with the low risk of cardiovascular disease in the Inuit? |
title_full |
DNA-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit--is there a relation with the low risk of cardiovascular disease in the Inuit? |
title_fullStr |
DNA-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit--is there a relation with the low risk of cardiovascular disease in the Inuit? |
title_full_unstemmed |
DNA-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit--is there a relation with the low risk of cardiovascular disease in the Inuit? |
title_sort |
dna-polymorphisms and plasma levels of vascular disease risk factors in greenland inuit--is there a relation with the low risk of cardiovascular disease in the inuit? |
publishDate |
1999 |
url |
https://portal.findresearcher.sdu.dk/da/publications/1b3b68f0-ec1c-11dc-86ef-000ea68e967b https://doi.org/10.1055/s-0037-1614522 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit inuits |
genre_facet |
Greenland inuit inuits |
op_source |
Maat , M D , Bladbjerg , E-M , Johansen , L G , de Knijff , P , Gram , J , Kluft , C & Jespersen , J 1999 , ' DNA-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit--is there a relation with the low risk of cardiovascular disease in the Inuit? ' , Thrombosis and Haemostasis , vol. 81 , no. 4 , pp. 547-52 . https://doi.org/10.1055/s-0037-1614522 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/1b3b68f0-ec1c-11dc-86ef-000ea68e967b |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1055/s-0037-1614522 |
container_title |
Thrombosis and Haemostasis |
container_volume |
81 |
container_issue |
04 |
container_start_page |
547 |
op_container_end_page |
552 |
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1798846670421622784 |