Multiple sclerosis in a family on the Faroe Islands
Udgivelsesdato: 2010-Jan BACKGROUND: John Kurtzke has proposed that multiple sclerosis (MS) on the Faroe Islands occurred as a result of the spread of a transmittable agent brought to the country during World War II. AIM: Kurtzke's theory has been opposed earlier and in this study, we present a...
Published in: | Acta Neurologica Scandinavica |
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ftsydanskunivpub:oai:sdu.dk:publications/0c033330-0408-11df-aefb-000ea68e967b 2024-05-19T07:40:01+00:00 Multiple sclerosis in a family on the Faroe Islands Binzer, Stefanie Imrell, K Binzer, M Vang, S Rogvi-Hansen, B Hillert, J Stenager, E 2010-01-01 https://portal.findresearcher.sdu.dk/da/publications/0c033330-0408-11df-aefb-000ea68e967b https://doi.org/10.1111/j.1600-0404.2009.01291.x eng eng https://portal.findresearcher.sdu.dk/da/publications/0c033330-0408-11df-aefb-000ea68e967b info:eu-repo/semantics/restrictedAccess Binzer , S , Imrell , K , Binzer , M , Vang , S , Rogvi-Hansen , B , Hillert , J & Stenager , E 2010 , ' Multiple sclerosis in a family on the Faroe Islands ' , Acta Neurologica Scandinavica , vol. 121 , no. 1 , pp. 16-9 . https://doi.org/10.1111/j.1600-0404.2009.01291.x article 2010 ftsydanskunivpub https://doi.org/10.1111/j.1600-0404.2009.01291.x 2024-05-01T00:14:11Z Udgivelsesdato: 2010-Jan BACKGROUND: John Kurtzke has proposed that multiple sclerosis (MS) on the Faroe Islands occurred as a result of the spread of a transmittable agent brought to the country during World War II. AIM: Kurtzke's theory has been opposed earlier and in this study, we present a family from the Faroe Islands containing a total of 14 family members with MS which show further inconsistencies with the theory. The present study is to our knowledge, the first description of familial incidences of MS on the Faroe Islands. METHODS: Medical histories were gathered from 12 family members and 6 of the 8 living MS cases were human leukocyte antigen (HLA)-typed. RESULTS: Seven family members had primary progressive MS (PPMS), while five had relapsing remitting MS. The HLA-DR15 allele was carried by the three cases with the most aggressive form of MS and they shared a common haplotypes. The HLA types carried by the remaining cases varied. CONCLUSION: This research questions Kurtzke's theory as three of the cases do not conform to the epidemic cohorts described. Furthermore, there appears to be a higher than usual prevalence of PPMS. The high degree of heterogeneity of the HLA types carried indicates that HLA alleles do not independently explain the risk of developing MS. Article in Journal/Newspaper Faroe Islands University of Southern Denmark Research Portal Acta Neurologica Scandinavica 121 1 16 19 |
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University of Southern Denmark Research Portal |
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ftsydanskunivpub |
language |
English |
description |
Udgivelsesdato: 2010-Jan BACKGROUND: John Kurtzke has proposed that multiple sclerosis (MS) on the Faroe Islands occurred as a result of the spread of a transmittable agent brought to the country during World War II. AIM: Kurtzke's theory has been opposed earlier and in this study, we present a family from the Faroe Islands containing a total of 14 family members with MS which show further inconsistencies with the theory. The present study is to our knowledge, the first description of familial incidences of MS on the Faroe Islands. METHODS: Medical histories were gathered from 12 family members and 6 of the 8 living MS cases were human leukocyte antigen (HLA)-typed. RESULTS: Seven family members had primary progressive MS (PPMS), while five had relapsing remitting MS. The HLA-DR15 allele was carried by the three cases with the most aggressive form of MS and they shared a common haplotypes. The HLA types carried by the remaining cases varied. CONCLUSION: This research questions Kurtzke's theory as three of the cases do not conform to the epidemic cohorts described. Furthermore, there appears to be a higher than usual prevalence of PPMS. The high degree of heterogeneity of the HLA types carried indicates that HLA alleles do not independently explain the risk of developing MS. |
format |
Article in Journal/Newspaper |
author |
Binzer, Stefanie Imrell, K Binzer, M Vang, S Rogvi-Hansen, B Hillert, J Stenager, E |
spellingShingle |
Binzer, Stefanie Imrell, K Binzer, M Vang, S Rogvi-Hansen, B Hillert, J Stenager, E Multiple sclerosis in a family on the Faroe Islands |
author_facet |
Binzer, Stefanie Imrell, K Binzer, M Vang, S Rogvi-Hansen, B Hillert, J Stenager, E |
author_sort |
Binzer, Stefanie |
title |
Multiple sclerosis in a family on the Faroe Islands |
title_short |
Multiple sclerosis in a family on the Faroe Islands |
title_full |
Multiple sclerosis in a family on the Faroe Islands |
title_fullStr |
Multiple sclerosis in a family on the Faroe Islands |
title_full_unstemmed |
Multiple sclerosis in a family on the Faroe Islands |
title_sort |
multiple sclerosis in a family on the faroe islands |
publishDate |
2010 |
url |
https://portal.findresearcher.sdu.dk/da/publications/0c033330-0408-11df-aefb-000ea68e967b https://doi.org/10.1111/j.1600-0404.2009.01291.x |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Binzer , S , Imrell , K , Binzer , M , Vang , S , Rogvi-Hansen , B , Hillert , J & Stenager , E 2010 , ' Multiple sclerosis in a family on the Faroe Islands ' , Acta Neurologica Scandinavica , vol. 121 , no. 1 , pp. 16-9 . https://doi.org/10.1111/j.1600-0404.2009.01291.x |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/0c033330-0408-11df-aefb-000ea68e967b |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1111/j.1600-0404.2009.01291.x |
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Acta Neurologica Scandinavica |
container_volume |
121 |
container_issue |
1 |
container_start_page |
16 |
op_container_end_page |
19 |
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