Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor:A Population-Based, Environmental Epidemiology Study in the Faroe Islands
Background: Essential tremor (ET) is among the most prevalent neurological diseases. Its environmental determinants are poorly understood. Harmane (1-methyl-9H-pyrido[3, 4-b]indole), a dietary tremor-producing neurotoxin, has been linked to ET in a few studies in New York and Madrid. Mercury, also a...
Published in: | Neuroepidemiology |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2020
|
Subjects: | |
Online Access: | https://portal.findresearcher.sdu.dk/da/publications/0804dc04-f96d-4d8f-b2e0-ecdbc82d6ffd https://doi.org/10.1159/000505874 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210050/pdf/nihms-1558051.pdf |
id |
ftsydanskunivpub:oai:sdu.dk:publications/0804dc04-f96d-4d8f-b2e0-ecdbc82d6ffd |
---|---|
record_format |
openpolar |
spelling |
ftsydanskunivpub:oai:sdu.dk:publications/0804dc04-f96d-4d8f-b2e0-ecdbc82d6ffd 2023-05-15T16:10:34+02:00 Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor:A Population-Based, Environmental Epidemiology Study in the Faroe Islands Louis, Elan D. Eliasen, Eina H. Ferrer, Monica Iglesias Hernandez, Daniella Gaini, Shahin Jiang, Wendy Zheng, Wei Nielsen, Flemming Petersen, Maria Skaalum 2020 https://portal.findresearcher.sdu.dk/da/publications/0804dc04-f96d-4d8f-b2e0-ecdbc82d6ffd https://doi.org/10.1159/000505874 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210050/pdf/nihms-1558051.pdf eng eng info:eu-repo/semantics/openAccess Louis , E D , Eliasen , E H , Ferrer , M , Iglesias Hernandez , D , Gaini , S , Jiang , W , Zheng , W , Nielsen , F & Petersen , M S 2020 , ' Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor : A Population-Based, Environmental Epidemiology Study in the Faroe Islands ' , Neuroepidemiology , vol. 54 , no. 3 , pp. 272-280 . https://doi.org/10.1159/000505874 Case-control study Environmental epidemiology Essential tremor Faroe Islands Harmane Mercury Neurotoxin Population based design article 2020 ftsydanskunivpub https://doi.org/10.1159/000505874 2022-08-14T10:21:28Z Background: Essential tremor (ET) is among the most prevalent neurological diseases. Its environmental determinants are poorly understood. Harmane (1-methyl-9H-pyrido[3, 4-b]indole), a dietary tremor-producing neurotoxin, has been linked to ET in a few studies in New York and Madrid. Mercury, also a tremor-producing neurotoxin, has not been studied in ET. The Faroe Islands have been the focus of epidemiological investigations of numerous neurological disorders. Objective: In this population-based, case-control study, we directly measured blood harmane concentrations (HA) and blood mercury concentrations (Hg) in ET cases and controls. Methods: In total, 1,328 Faroese adults were screened; 26 ET cases were identified whose (HA) and (Hg) were compared to 197 controls. Results: Although there were no statistically significant differences between diagnostic groups, median (HA) was 2.7× higher in definite ET (4.13 g -10 /mL) and 1.5× higher in probable ET (2.28 g -10 /mL) than controls (1.53 g -10 /mL). Small sample size was a limitation. For definite ET versus controls, p = 0.126. (Hg) were similar between groups. Conclusions: We demonstrated marginally elevated (HA) in definite and probable ET. These data are similar to those previously published and possibly extend etiological links between this neurotoxin and ET to a third locale. The study did not support a link between mercury and ET. Article in Journal/Newspaper Faroe Islands University of Southern Denmark Research Portal Faroe Islands Neuroepidemiology 54 3 272 280 |
institution |
Open Polar |
collection |
University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
Case-control study Environmental epidemiology Essential tremor Faroe Islands Harmane Mercury Neurotoxin Population based design |
spellingShingle |
Case-control study Environmental epidemiology Essential tremor Faroe Islands Harmane Mercury Neurotoxin Population based design Louis, Elan D. Eliasen, Eina H. Ferrer, Monica Iglesias Hernandez, Daniella Gaini, Shahin Jiang, Wendy Zheng, Wei Nielsen, Flemming Petersen, Maria Skaalum Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor:A Population-Based, Environmental Epidemiology Study in the Faroe Islands |
topic_facet |
Case-control study Environmental epidemiology Essential tremor Faroe Islands Harmane Mercury Neurotoxin Population based design |
description |
Background: Essential tremor (ET) is among the most prevalent neurological diseases. Its environmental determinants are poorly understood. Harmane (1-methyl-9H-pyrido[3, 4-b]indole), a dietary tremor-producing neurotoxin, has been linked to ET in a few studies in New York and Madrid. Mercury, also a tremor-producing neurotoxin, has not been studied in ET. The Faroe Islands have been the focus of epidemiological investigations of numerous neurological disorders. Objective: In this population-based, case-control study, we directly measured blood harmane concentrations (HA) and blood mercury concentrations (Hg) in ET cases and controls. Methods: In total, 1,328 Faroese adults were screened; 26 ET cases were identified whose (HA) and (Hg) were compared to 197 controls. Results: Although there were no statistically significant differences between diagnostic groups, median (HA) was 2.7× higher in definite ET (4.13 g -10 /mL) and 1.5× higher in probable ET (2.28 g -10 /mL) than controls (1.53 g -10 /mL). Small sample size was a limitation. For definite ET versus controls, p = 0.126. (Hg) were similar between groups. Conclusions: We demonstrated marginally elevated (HA) in definite and probable ET. These data are similar to those previously published and possibly extend etiological links between this neurotoxin and ET to a third locale. The study did not support a link between mercury and ET. |
format |
Article in Journal/Newspaper |
author |
Louis, Elan D. Eliasen, Eina H. Ferrer, Monica Iglesias Hernandez, Daniella Gaini, Shahin Jiang, Wendy Zheng, Wei Nielsen, Flemming Petersen, Maria Skaalum |
author_facet |
Louis, Elan D. Eliasen, Eina H. Ferrer, Monica Iglesias Hernandez, Daniella Gaini, Shahin Jiang, Wendy Zheng, Wei Nielsen, Flemming Petersen, Maria Skaalum |
author_sort |
Louis, Elan D. |
title |
Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor:A Population-Based, Environmental Epidemiology Study in the Faroe Islands |
title_short |
Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor:A Population-Based, Environmental Epidemiology Study in the Faroe Islands |
title_full |
Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor:A Population-Based, Environmental Epidemiology Study in the Faroe Islands |
title_fullStr |
Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor:A Population-Based, Environmental Epidemiology Study in the Faroe Islands |
title_full_unstemmed |
Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor:A Population-Based, Environmental Epidemiology Study in the Faroe Islands |
title_sort |
blood harmane (1-methyl-9h-pyrido[3,4-b]indole) and mercury in essential tremor:a population-based, environmental epidemiology study in the faroe islands |
publishDate |
2020 |
url |
https://portal.findresearcher.sdu.dk/da/publications/0804dc04-f96d-4d8f-b2e0-ecdbc82d6ffd https://doi.org/10.1159/000505874 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210050/pdf/nihms-1558051.pdf |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Louis , E D , Eliasen , E H , Ferrer , M , Iglesias Hernandez , D , Gaini , S , Jiang , W , Zheng , W , Nielsen , F & Petersen , M S 2020 , ' Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor : A Population-Based, Environmental Epidemiology Study in the Faroe Islands ' , Neuroepidemiology , vol. 54 , no. 3 , pp. 272-280 . https://doi.org/10.1159/000505874 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1159/000505874 |
container_title |
Neuroepidemiology |
container_volume |
54 |
container_issue |
3 |
container_start_page |
272 |
op_container_end_page |
280 |
_version_ |
1765995739338506240 |