The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland
The aim of this study was to examine the effect of diabetes and the diabetogenic TBC1D4 variant on kidney function in Greenland in a population-based setting. Health survey data and TBC1D4 genotypes from 5,336 Greenlanders were used to estimate odds ratios (ORs) of albuminuria (>30 mg/g creatinin...
Published in: | International Journal of Circumpolar Health |
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Format: | Article in Journal/Newspaper |
Language: | English |
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2023
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Online Access: | https://portal.findresearcher.sdu.dk/da/publications/0571df03-a533-4926-81f8-e80962f495d5 https://doi.org/10.1080/22423982.2023.2191406 https://findresearcher.sdu.dk/ws/files/226205702/The_effect_of_diabetes_and_the_diabetogenic_TBC1D4_p_Arg684ter_variant_on_kidney_function_in_Inuit_in_Greenland.pdf |
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ftsydanskunivpub:oai:sdu.dk:publications/0571df03-a533-4926-81f8-e80962f495d5 2024-05-19T07:39:02+00:00 The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland Overvad, Maria Díaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Grarup, Niels Hansen, Torben Rossing, Peter Jørgensen, Marit Eika 2023 application/pdf https://portal.findresearcher.sdu.dk/da/publications/0571df03-a533-4926-81f8-e80962f495d5 https://doi.org/10.1080/22423982.2023.2191406 https://findresearcher.sdu.dk/ws/files/226205702/The_effect_of_diabetes_and_the_diabetogenic_TBC1D4_p_Arg684ter_variant_on_kidney_function_in_Inuit_in_Greenland.pdf eng eng https://portal.findresearcher.sdu.dk/da/publications/0571df03-a533-4926-81f8-e80962f495d5 info:eu-repo/semantics/openAccess Overvad , M , Díaz , L J , Bjerregaard , P , Pedersen , M L , Larsen , C V L , Grarup , N , Hansen , T , Rossing , P & Jørgensen , M E 2023 , ' The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland ' , International Journal of Circumpolar Health , vol. 82 , no. 1 , 2191406 . https://doi.org/10.1080/22423982.2023.2191406 CKD complications diabetes genetics Greenland article 2023 ftsydanskunivpub https://doi.org/10.1080/22423982.2023.2191406 2024-05-01T00:39:37Z The aim of this study was to examine the effect of diabetes and the diabetogenic TBC1D4 variant on kidney function in Greenland in a population-based setting. Health survey data and TBC1D4 genotypes from 5,336 Greenlanders were used to estimate odds ratios (ORs) of albuminuria (>30 mg/g creatinine) and chronic kidney disease (CKD, eGFR <60 ml/min/1.73m 2 ), comparing individuals with and without diabetes, including the effect of TBC1D4 variant. Of the 3,909 participants with complete data, 9.3% had diabetes. Albuminuria was found in 27.6% and 9.5% and CKD was found in 10.8% and 6.3% among those with and without diabetes, respectively. Diabetes was cross-sectionally associated with an increased risk of albuminuria (OR (95% CI) = 2.37 (1.69,3.33); p < 0.001) and the TBC1D4 variant protected against albuminuria (OR (95% CI) = 0.44 (0.22,0.90); p = 0.02) in a multivariable model. Neither diabetes nor the TBC1D4 variant significantly associated with CKD. The presence/absence of diabetes did not predict changes in eGFR and UACR in longitudinal analyses. Diabetes conferred an increased risk of albuminuria, and the TBC1D4 variant was associated with a decreased risk of albuminuria, but neither was associated with CKD. The potential renoprotective association of the TBC1D4 variant on albuminuria calls for further studies. Article in Journal/Newspaper Circumpolar Health Greenland greenlander* International Journal of Circumpolar Health inuit University of Southern Denmark Research Portal International Journal of Circumpolar Health 82 1 |
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University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
CKD complications diabetes genetics Greenland |
spellingShingle |
CKD complications diabetes genetics Greenland Overvad, Maria Díaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Grarup, Niels Hansen, Torben Rossing, Peter Jørgensen, Marit Eika The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland |
topic_facet |
CKD complications diabetes genetics Greenland |
description |
The aim of this study was to examine the effect of diabetes and the diabetogenic TBC1D4 variant on kidney function in Greenland in a population-based setting. Health survey data and TBC1D4 genotypes from 5,336 Greenlanders were used to estimate odds ratios (ORs) of albuminuria (>30 mg/g creatinine) and chronic kidney disease (CKD, eGFR <60 ml/min/1.73m 2 ), comparing individuals with and without diabetes, including the effect of TBC1D4 variant. Of the 3,909 participants with complete data, 9.3% had diabetes. Albuminuria was found in 27.6% and 9.5% and CKD was found in 10.8% and 6.3% among those with and without diabetes, respectively. Diabetes was cross-sectionally associated with an increased risk of albuminuria (OR (95% CI) = 2.37 (1.69,3.33); p < 0.001) and the TBC1D4 variant protected against albuminuria (OR (95% CI) = 0.44 (0.22,0.90); p = 0.02) in a multivariable model. Neither diabetes nor the TBC1D4 variant significantly associated with CKD. The presence/absence of diabetes did not predict changes in eGFR and UACR in longitudinal analyses. Diabetes conferred an increased risk of albuminuria, and the TBC1D4 variant was associated with a decreased risk of albuminuria, but neither was associated with CKD. The potential renoprotective association of the TBC1D4 variant on albuminuria calls for further studies. |
format |
Article in Journal/Newspaper |
author |
Overvad, Maria Díaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Grarup, Niels Hansen, Torben Rossing, Peter Jørgensen, Marit Eika |
author_facet |
Overvad, Maria Díaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Grarup, Niels Hansen, Torben Rossing, Peter Jørgensen, Marit Eika |
author_sort |
Overvad, Maria |
title |
The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland |
title_short |
The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland |
title_full |
The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland |
title_fullStr |
The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland |
title_full_unstemmed |
The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland |
title_sort |
effect of diabetes and the diabetogenic tbc1d4 p.arg684ter variant on kidney function in inuit in greenland |
publishDate |
2023 |
url |
https://portal.findresearcher.sdu.dk/da/publications/0571df03-a533-4926-81f8-e80962f495d5 https://doi.org/10.1080/22423982.2023.2191406 https://findresearcher.sdu.dk/ws/files/226205702/The_effect_of_diabetes_and_the_diabetogenic_TBC1D4_p_Arg684ter_variant_on_kidney_function_in_Inuit_in_Greenland.pdf |
genre |
Circumpolar Health Greenland greenlander* International Journal of Circumpolar Health inuit |
genre_facet |
Circumpolar Health Greenland greenlander* International Journal of Circumpolar Health inuit |
op_source |
Overvad , M , Díaz , L J , Bjerregaard , P , Pedersen , M L , Larsen , C V L , Grarup , N , Hansen , T , Rossing , P & Jørgensen , M E 2023 , ' The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland ' , International Journal of Circumpolar Health , vol. 82 , no. 1 , 2191406 . https://doi.org/10.1080/22423982.2023.2191406 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/0571df03-a533-4926-81f8-e80962f495d5 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1080/22423982.2023.2191406 |
container_title |
International Journal of Circumpolar Health |
container_volume |
82 |
container_issue |
1 |
_version_ |
1799478550593536000 |