Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar.
International audience In Madagascar, the black rat, Rattus rattus, is the main reservoir of plague (Yersinia pestis infection), a disease still responsible for hundreds of cases each year in this country. This study used experimental plague challenge to assess susceptibility in wild-caught rats to...
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ftsupagro:oai:HAL:pasteur-00836576v1 2024-09-15T18:31:58+00:00 Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar. Tollenaere, C. Rahalison, L. Ranjalahy, M. Duplantier, J.-M. Rahelinirina, S. Telfer, S. Brouat, C. Centre de Biologie pour la Gestion des Populations (UMR CBGP) Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD France-Sud )-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro) Unité Peste - Plague Unit Antananarivo, Madagascar Institut Pasteur de Madagascar Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) Institute of Environmental and Biological Sciences University of Aberdeen 2010-06 https://riip.hal.science/pasteur-00836576 https://doi.org/10.1007/s10393-010-0312-3 en eng HAL CCSD Springer Verlag info:eu-repo/semantics/altIdentifier/doi/10.1007/s10393-010-0312-3 info:eu-repo/semantics/altIdentifier/pmid/20443044 pasteur-00836576 https://riip.hal.science/pasteur-00836576 doi:10.1007/s10393-010-0312-3 PRODINRA: 315696 PUBMED: 20443044 WOS: 000285911700010 ISSN: 1612-9202 EISSN: 1612-9210 EcoHealth https://riip.hal.science/pasteur-00836576 EcoHealth, 2010, 7 (2), pp.242-7. ⟨10.1007/s10393-010-0312-3⟩ Experimental challenge infectious disease resistance Madagascar pathogen-mediated selection rodent-borne disease Yersinia pestis MESH: Animals MESH: Antibodies Bacterial MESH: Sex Factors MESH: Survival Analysis MESH: Yersinia pestis MESH: Disease Models Animal MESH: Disease Reservoirs MESH: Enzyme-Linked Immunosorbent Assay MESH: Female MESH: Madagascar MESH: Male MESH: Plague MESH: Rats [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2010 ftsupagro https://doi.org/10.1007/s10393-010-0312-3 2024-07-24T23:30:43Z International audience In Madagascar, the black rat, Rattus rattus, is the main reservoir of plague (Yersinia pestis infection), a disease still responsible for hundreds of cases each year in this country. This study used experimental plague challenge to assess susceptibility in wild-caught rats to better understand how R. rattus can act as a plague reservoir. An important difference in plague resistance between rat populations from the plague focus (central highlands) and those from the plague-free zone (low altitude area) was confirmed to be a widespread phenomenon. In rats from the plague focus, we observed that sex influenced plague susceptibility, with males slightly more resistant than females. Other individual factors investigated (weight and habitat of sampling) did not affect plague resistance. When infected at high bacterial dose (more than 10⁵ bacteria injected), rats from the plague focus died mainly within 3-5 days and produced specific antibodies, whereas after low-dose infection (< 5,000 bacteria), delayed mortality was observed and surviving seronegative rats were not uncommon. These results concerning plague resistance level and the course of infection in the black rat would contribute to a better understanding of plague circulation in Madagascar. Article in Journal/Newspaper Rattus rattus Portail HAL Institut Agro Montpellier EcoHealth 7 2 242 247 |
institution |
Open Polar |
collection |
Portail HAL Institut Agro Montpellier |
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ftsupagro |
language |
English |
topic |
Experimental challenge infectious disease resistance Madagascar pathogen-mediated selection rodent-borne disease Yersinia pestis MESH: Animals MESH: Antibodies Bacterial MESH: Sex Factors MESH: Survival Analysis MESH: Yersinia pestis MESH: Disease Models Animal MESH: Disease Reservoirs MESH: Enzyme-Linked Immunosorbent Assay MESH: Female MESH: Madagascar MESH: Male MESH: Plague MESH: Rats [SDV]Life Sciences [q-bio] |
spellingShingle |
Experimental challenge infectious disease resistance Madagascar pathogen-mediated selection rodent-borne disease Yersinia pestis MESH: Animals MESH: Antibodies Bacterial MESH: Sex Factors MESH: Survival Analysis MESH: Yersinia pestis MESH: Disease Models Animal MESH: Disease Reservoirs MESH: Enzyme-Linked Immunosorbent Assay MESH: Female MESH: Madagascar MESH: Male MESH: Plague MESH: Rats [SDV]Life Sciences [q-bio] Tollenaere, C. Rahalison, L. Ranjalahy, M. Duplantier, J.-M. Rahelinirina, S. Telfer, S. Brouat, C. Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar. |
topic_facet |
Experimental challenge infectious disease resistance Madagascar pathogen-mediated selection rodent-borne disease Yersinia pestis MESH: Animals MESH: Antibodies Bacterial MESH: Sex Factors MESH: Survival Analysis MESH: Yersinia pestis MESH: Disease Models Animal MESH: Disease Reservoirs MESH: Enzyme-Linked Immunosorbent Assay MESH: Female MESH: Madagascar MESH: Male MESH: Plague MESH: Rats [SDV]Life Sciences [q-bio] |
description |
International audience In Madagascar, the black rat, Rattus rattus, is the main reservoir of plague (Yersinia pestis infection), a disease still responsible for hundreds of cases each year in this country. This study used experimental plague challenge to assess susceptibility in wild-caught rats to better understand how R. rattus can act as a plague reservoir. An important difference in plague resistance between rat populations from the plague focus (central highlands) and those from the plague-free zone (low altitude area) was confirmed to be a widespread phenomenon. In rats from the plague focus, we observed that sex influenced plague susceptibility, with males slightly more resistant than females. Other individual factors investigated (weight and habitat of sampling) did not affect plague resistance. When infected at high bacterial dose (more than 10⁵ bacteria injected), rats from the plague focus died mainly within 3-5 days and produced specific antibodies, whereas after low-dose infection (< 5,000 bacteria), delayed mortality was observed and surviving seronegative rats were not uncommon. These results concerning plague resistance level and the course of infection in the black rat would contribute to a better understanding of plague circulation in Madagascar. |
author2 |
Centre de Biologie pour la Gestion des Populations (UMR CBGP) Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD France-Sud )-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro) Unité Peste - Plague Unit Antananarivo, Madagascar Institut Pasteur de Madagascar Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) Institute of Environmental and Biological Sciences University of Aberdeen |
format |
Article in Journal/Newspaper |
author |
Tollenaere, C. Rahalison, L. Ranjalahy, M. Duplantier, J.-M. Rahelinirina, S. Telfer, S. Brouat, C. |
author_facet |
Tollenaere, C. Rahalison, L. Ranjalahy, M. Duplantier, J.-M. Rahelinirina, S. Telfer, S. Brouat, C. |
author_sort |
Tollenaere, C. |
title |
Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar. |
title_short |
Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar. |
title_full |
Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar. |
title_fullStr |
Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar. |
title_full_unstemmed |
Susceptibility to Yersinia pestis experimental infection in wild Rattus rattus, reservoir of plague in Madagascar. |
title_sort |
susceptibility to yersinia pestis experimental infection in wild rattus rattus, reservoir of plague in madagascar. |
publisher |
HAL CCSD |
publishDate |
2010 |
url |
https://riip.hal.science/pasteur-00836576 https://doi.org/10.1007/s10393-010-0312-3 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
ISSN: 1612-9202 EISSN: 1612-9210 EcoHealth https://riip.hal.science/pasteur-00836576 EcoHealth, 2010, 7 (2), pp.242-7. ⟨10.1007/s10393-010-0312-3⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10393-010-0312-3 info:eu-repo/semantics/altIdentifier/pmid/20443044 pasteur-00836576 https://riip.hal.science/pasteur-00836576 doi:10.1007/s10393-010-0312-3 PRODINRA: 315696 PUBMED: 20443044 WOS: 000285911700010 |
op_doi |
https://doi.org/10.1007/s10393-010-0312-3 |
container_title |
EcoHealth |
container_volume |
7 |
container_issue |
2 |
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242 |
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247 |
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