Gut bacteria of animals/pests are potential source of antibacterial molecules(s)
Infectious diseases, in particular bacterial infections are the leading cause of morbidity and mortality, posing a global threat to human health. The emergence of antibiotic resistance has exacerbated the problem further. The majority of antibiotics available in the market are produced by bacteria i...
Main Author: | |
---|---|
Format: | Thesis |
Language: | unknown |
Published: |
2019
|
Subjects: | |
Online Access: | http://eprints.sunway.edu.my/2386/ |
id |
ftsunwayuniv:oai:eprints.sunway.edu.my:2386 |
---|---|
record_format |
openpolar |
spelling |
ftsunwayuniv:oai:eprints.sunway.edu.my:2386 2023-10-29T02:39:45+01:00 Gut bacteria of animals/pests are potential source of antibacterial molecules(s) Noor, Akbar 2019 http://eprints.sunway.edu.my/2386/ unknown Noor, Akbar (2019) Gut bacteria of animals/pests are potential source of antibacterial molecules(s). Doctoral thesis, Sunway University. QH Natural history RA Public aspects of medicine RC Internal medicine Thesis NonPeerReviewed 2019 ftsunwayuniv 2023-10-03T17:47:20Z Infectious diseases, in particular bacterial infections are the leading cause of morbidity and mortality, posing a global threat to human health. The emergence of antibiotic resistance has exacerbated the problem further. The majority of antibiotics available in the market are produced by bacteria isolated from soil. However, the “low-hanging fruit” has been picked, hence there is a need to mine bacteria from unusual sources. With this in mind, it is important to note that animals and pests such as cockroaches, snake, crocodiles, water monitor lizard. come across pathogenic bacteria regularly yet flourish in contaminated environments. These species must have developed methods to defend themselves to counter pathogens. Although the immune system is known to possess anti-infective properties, gut bacteria of animals/pests may also offer a potential source of novel antibacterial(s) and it is the subject of this study. Herein, we explored gut bacteria of various animals/pests living in polluted environments for their antibacterial properties against multi-drug resistant pathogenic bacteria. A variety of animals/pests species were procured including invertebrate species, Blaptica dubia (cockroach), Gromphadorhina portentosa (cockroach), Scylla serrata (crab), Grammostola rosea (tarantula), Scolopendra subspinipes (centipede) and vertebrate species including Varanus salvator (water monitor lizard), Malayopython reticulatus (python), Cuora amboinensis (tortoise), Oreochromis mossambicus (tilapia fish), Rattus rattus (rat), Gallus gallus domesticus (chicken) and Lithobates catesbeianus (frog). Gut bacteria of animals/pests were isolated and identified using microbiological, biochemical and molecular identification methods. Bacterial conditioned media were prepared using Roswell Park Memorial Institute (RPMI) medium and tested against selected Gram-positive and Gram-negative pathogenic bacteria as well as human cells. The results revealed that conditioned media of gut bacteria exhibited significant broad-spectrum ... Thesis Rattus rattus Sunway Institutional Repository (Sunway University College) |
institution |
Open Polar |
collection |
Sunway Institutional Repository (Sunway University College) |
op_collection_id |
ftsunwayuniv |
language |
unknown |
topic |
QH Natural history RA Public aspects of medicine RC Internal medicine |
spellingShingle |
QH Natural history RA Public aspects of medicine RC Internal medicine Noor, Akbar Gut bacteria of animals/pests are potential source of antibacterial molecules(s) |
topic_facet |
QH Natural history RA Public aspects of medicine RC Internal medicine |
description |
Infectious diseases, in particular bacterial infections are the leading cause of morbidity and mortality, posing a global threat to human health. The emergence of antibiotic resistance has exacerbated the problem further. The majority of antibiotics available in the market are produced by bacteria isolated from soil. However, the “low-hanging fruit” has been picked, hence there is a need to mine bacteria from unusual sources. With this in mind, it is important to note that animals and pests such as cockroaches, snake, crocodiles, water monitor lizard. come across pathogenic bacteria regularly yet flourish in contaminated environments. These species must have developed methods to defend themselves to counter pathogens. Although the immune system is known to possess anti-infective properties, gut bacteria of animals/pests may also offer a potential source of novel antibacterial(s) and it is the subject of this study. Herein, we explored gut bacteria of various animals/pests living in polluted environments for their antibacterial properties against multi-drug resistant pathogenic bacteria. A variety of animals/pests species were procured including invertebrate species, Blaptica dubia (cockroach), Gromphadorhina portentosa (cockroach), Scylla serrata (crab), Grammostola rosea (tarantula), Scolopendra subspinipes (centipede) and vertebrate species including Varanus salvator (water monitor lizard), Malayopython reticulatus (python), Cuora amboinensis (tortoise), Oreochromis mossambicus (tilapia fish), Rattus rattus (rat), Gallus gallus domesticus (chicken) and Lithobates catesbeianus (frog). Gut bacteria of animals/pests were isolated and identified using microbiological, biochemical and molecular identification methods. Bacterial conditioned media were prepared using Roswell Park Memorial Institute (RPMI) medium and tested against selected Gram-positive and Gram-negative pathogenic bacteria as well as human cells. The results revealed that conditioned media of gut bacteria exhibited significant broad-spectrum ... |
format |
Thesis |
author |
Noor, Akbar |
author_facet |
Noor, Akbar |
author_sort |
Noor, Akbar |
title |
Gut bacteria of animals/pests are potential source of antibacterial molecules(s) |
title_short |
Gut bacteria of animals/pests are potential source of antibacterial molecules(s) |
title_full |
Gut bacteria of animals/pests are potential source of antibacterial molecules(s) |
title_fullStr |
Gut bacteria of animals/pests are potential source of antibacterial molecules(s) |
title_full_unstemmed |
Gut bacteria of animals/pests are potential source of antibacterial molecules(s) |
title_sort |
gut bacteria of animals/pests are potential source of antibacterial molecules(s) |
publishDate |
2019 |
url |
http://eprints.sunway.edu.my/2386/ |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
Noor, Akbar (2019) Gut bacteria of animals/pests are potential source of antibacterial molecules(s). Doctoral thesis, Sunway University. |
_version_ |
1781067053889748992 |