Comparative analysis of the thermogenic protein UCP1 across the mammalian phylogeny

• Main Author: Gaudry, Michael James
• Format: Doctoral or Postdoctoral Thesis
• Language: English
• Published: Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut 2023
• Subjects: Uncoupling protein 1; Evolution; Non-shivering thermogenesis; Brown adipose tissue; Biological Sciences; Biologiska vetenskaper; Browning; Elephant Seals
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-223504

Uncoupling protein 1 (UCP1) drives mitochondrial inefficiency to produce heat in mammalian brown adipose tissue (BAT). Many mammalian species rely on this form of adaptive non-shivering thermogenesis (NST) to defend high body temperatures in the cold. Little is known regarding how evolution may have...