How are genetic factors influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga?
115 leaves : ill. (some col.) 29 cm Includes abstract. Includes bibliographical references. The purpose of this project was to understand how genetic factors may be influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga. To assess if variation along candidate genes are i...
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Halifax, N.S. : Saint Mary's University
2016
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ftstmarysunivca:oai:library2:01/26702 2023-05-15T15:41:44+02:00 How are genetic factors influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga? Arif, Suchinta Frasier, Timothy, 1976- 2016 application/pdf http://library2.smu.ca/handle/01/26702 en eng Halifax, N.S. : Saint Mary's University QL737 C433 A75 2016 http://library2.smu.ca/handle/01/26702 QL737.C433 White whale -- Saint Lawrence River -- Genetics White whale -- Saint Lawrence River -- Mortality Cancer in animals -- Genetic aspects Cancer in animals -- Susceptibility Text 2016 ftstmarysunivca 2022-05-13T05:48:41Z 115 leaves : ill. (some col.) 29 cm Includes abstract. Includes bibliographical references. The purpose of this project was to understand how genetic factors may be influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga. To assess if variation along candidate genes are influencing cancer susceptibility, I designed primers for the amplification of the p53 gene, and microsatellite regions along seven additional genes: p16, Rb1, BRCA1, BRCA2, PTEN, HPSE2, and FOXO3. Comparing cancer individuals to a control group showed no strong differences with respect to variation along the p53 gene (sequencing analysis) or other candidate loci (microsatellite association analysis), though some patterns warrant further investigation. The degree of inbreeding also showed no relationship with cancer susceptibility. However, bacteria and parasite-induced mortalities were associated with relatively high and low levels of inbreeding, respectively, highlighting the different ways in which inbreeding may be influencing mortality patterns in this population. Text Beluga Beluga* White whale Saint Mary's University, Halifax: Institutional Repository Lawrence River ENVELOPE(-115.002,-115.002,58.384,58.384) |
institution |
Open Polar |
collection |
Saint Mary's University, Halifax: Institutional Repository |
op_collection_id |
ftstmarysunivca |
language |
English |
topic |
QL737.C433 White whale -- Saint Lawrence River -- Genetics White whale -- Saint Lawrence River -- Mortality Cancer in animals -- Genetic aspects Cancer in animals -- Susceptibility |
spellingShingle |
QL737.C433 White whale -- Saint Lawrence River -- Genetics White whale -- Saint Lawrence River -- Mortality Cancer in animals -- Genetic aspects Cancer in animals -- Susceptibility Arif, Suchinta How are genetic factors influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga? |
topic_facet |
QL737.C433 White whale -- Saint Lawrence River -- Genetics White whale -- Saint Lawrence River -- Mortality Cancer in animals -- Genetic aspects Cancer in animals -- Susceptibility |
description |
115 leaves : ill. (some col.) 29 cm Includes abstract. Includes bibliographical references. The purpose of this project was to understand how genetic factors may be influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga. To assess if variation along candidate genes are influencing cancer susceptibility, I designed primers for the amplification of the p53 gene, and microsatellite regions along seven additional genes: p16, Rb1, BRCA1, BRCA2, PTEN, HPSE2, and FOXO3. Comparing cancer individuals to a control group showed no strong differences with respect to variation along the p53 gene (sequencing analysis) or other candidate loci (microsatellite association analysis), though some patterns warrant further investigation. The degree of inbreeding also showed no relationship with cancer susceptibility. However, bacteria and parasite-induced mortalities were associated with relatively high and low levels of inbreeding, respectively, highlighting the different ways in which inbreeding may be influencing mortality patterns in this population. |
author2 |
Frasier, Timothy, 1976- |
format |
Text |
author |
Arif, Suchinta |
author_facet |
Arif, Suchinta |
author_sort |
Arif, Suchinta |
title |
How are genetic factors influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga? |
title_short |
How are genetic factors influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga? |
title_full |
How are genetic factors influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga? |
title_fullStr |
How are genetic factors influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga? |
title_full_unstemmed |
How are genetic factors influencing cancer susceptibility and mortality patterns in the St. Lawrence beluga? |
title_sort |
how are genetic factors influencing cancer susceptibility and mortality patterns in the st. lawrence beluga? |
publisher |
Halifax, N.S. : Saint Mary's University |
publishDate |
2016 |
url |
http://library2.smu.ca/handle/01/26702 |
long_lat |
ENVELOPE(-115.002,-115.002,58.384,58.384) |
geographic |
Lawrence River |
geographic_facet |
Lawrence River |
genre |
Beluga Beluga* White whale |
genre_facet |
Beluga Beluga* White whale |
op_relation |
QL737 C433 A75 2016 http://library2.smu.ca/handle/01/26702 |
_version_ |
1766374634897276928 |