Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002
The study was supported by the Villum Foundation, the Danish Ministry of the Environment, the Volkswagen Foundation (Az.: 89911) and the BONUS programme BaltHealth, which has received funding from BONUS (Art. 185), funded jointly by the EU, Innovation Fund Denmark (grants 6180-00001B and 6180-00002B...
Published in: | Diseases of Aquatic Organisms |
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Main Authors: | , , , , , , , , , , , |
Other Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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2020
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Online Access: | http://hdl.handle.net/10023/19511 https://doi.org/10.3354/dao03328 |
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ftstandrewserep:oai:research-repository.st-andrews.ac.uk:10023/19511 |
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institution |
Open Polar |
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University of St Andrews: Digital Research Repository |
op_collection_id |
ftstandrewserep |
language |
English |
topic |
Epidemic Morbillivirus Viral phylogeny Virus evolution Wildlife pathogen GC Oceanography QH301 Biology Ecology Evolution Behavior and Systematics Aquatic Science NDAS SDG 10 - Reduced Inequalities SDG 14 - Life Below Water GC QH301 |
spellingShingle |
Epidemic Morbillivirus Viral phylogeny Virus evolution Wildlife pathogen GC Oceanography QH301 Biology Ecology Evolution Behavior and Systematics Aquatic Science NDAS SDG 10 - Reduced Inequalities SDG 14 - Life Below Water GC QH301 Stokholm, Iben Härkönen, Tero Harding, Karin C. Siebert, Ursula Lehnert, Kristina Dietz, Rune Teilmann, Jonas Galatius, Anders Havmøller, Linnea Worsøe Carroll, Emma L. Hall, Ailsa Olsen, Morten Tange Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 |
topic_facet |
Epidemic Morbillivirus Viral phylogeny Virus evolution Wildlife pathogen GC Oceanography QH301 Biology Ecology Evolution Behavior and Systematics Aquatic Science NDAS SDG 10 - Reduced Inequalities SDG 14 - Life Below Water GC QH301 |
description |
The study was supported by the Villum Foundation, the Danish Ministry of the Environment, the Volkswagen Foundation (Az.: 89911) and the BONUS programme BaltHealth, which has received funding from BONUS (Art. 185), funded jointly by the EU, Innovation Fund Denmark (grants 6180-00001B and 6180-00002B), Forschungszentrum Jülich GmbH, German Federal Ministry of Education and Research (grant FKZ 03F0767A), Academy of Finland (grant 311966) and Swedish Foundation for Strategic Environmental Research (MISTRA). The 1988 and 2002 phocine distemper virus (PDV) outbreaks in European harbour seals Phoca vitulina are among the largest mass mortality events recorded in marine mammals. Despite its large impact on harbour seal population numbers, and 3 decades of studies, many questions regarding the spread and temporal origin of PDV remain unanswered. Here, we sequenced and analysed 7123 bp of the PDV genome, including the coding and non-coding regions of the entire P, M, F and H genes in tissues from 44 harbour seals to shed new light on the origin and spread of PDV in 1988 and 2002. The phylogenetic analyses trace the origin of the PDV strain causing the 1988 outbreak to between June 1987 and April 1988, while the origin of the strain causing the 2002 outbreak can be traced back to between July 2001 and April 2002. The analyses further point to several independent introductions of PDV in 1988, possibly linked to a southward mass immigration of harp seals in the winter and spring of 1987−1988. The vector for the 2002 outbreak is unknown, but the epidemiological analyses suggest the subsequent spread of PDV from the epicentre in the Kattegat, Denmark, to haul-out sites in the North Sea through several independent introductions. Postprint Peer reviewed |
author2 |
University of St Andrews. School of Biology University of St Andrews. Sea Mammal Research Unit University of St Andrews. Marine Alliance for Science & Technology Scotland University of St Andrews. Scottish Oceans Institute |
format |
Article in Journal/Newspaper |
author |
Stokholm, Iben Härkönen, Tero Harding, Karin C. Siebert, Ursula Lehnert, Kristina Dietz, Rune Teilmann, Jonas Galatius, Anders Havmøller, Linnea Worsøe Carroll, Emma L. Hall, Ailsa Olsen, Morten Tange |
author_facet |
Stokholm, Iben Härkönen, Tero Harding, Karin C. Siebert, Ursula Lehnert, Kristina Dietz, Rune Teilmann, Jonas Galatius, Anders Havmøller, Linnea Worsøe Carroll, Emma L. Hall, Ailsa Olsen, Morten Tange |
author_sort |
Stokholm, Iben |
title |
Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 |
title_short |
Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 |
title_full |
Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 |
title_fullStr |
Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 |
title_full_unstemmed |
Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 |
title_sort |
phylogenomic insights to the origin and spread of phocine distemper virus in european harbour seals in 1988 and 2002 |
publishDate |
2020 |
url |
http://hdl.handle.net/10023/19511 https://doi.org/10.3354/dao03328 |
long_lat |
ENVELOPE(9.692,9.692,63.563,63.563) |
geographic |
Kattegat |
geographic_facet |
Kattegat |
genre |
harbour seal Phoca vitulina |
genre_facet |
harbour seal Phoca vitulina |
op_relation |
Diseases of Aquatic Organisms Stokholm , I , Härkönen , T , Harding , K C , Siebert , U , Lehnert , K , Dietz , R , Teilmann , J , Galatius , A , Havmøller , L W , Carroll , E L , Hall , A & Olsen , M T 2019 , ' Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 ' , Diseases of Aquatic Organisms , vol. 133 , no. 1 , pp. 47-56 . https://doi.org/10.3354/dao03328 0177-5103 PURE: 258965270 PURE UUID: 3e3fa66c-0d9e-4030-8890-1ea8da781c5c Scopus: 85064695144 ORCID: /0000-0002-7562-1771/work/57568152 WOS: 000483878800006 http://hdl.handle.net/10023/19511 https://doi.org/10.3354/dao03328 |
op_rights |
Copyright © 2019 Inter-Research. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.3354/dao03328 |
op_doi |
https://doi.org/10.3354/dao03328 |
container_title |
Diseases of Aquatic Organisms |
container_volume |
133 |
container_issue |
1 |
container_start_page |
47 |
op_container_end_page |
56 |
_version_ |
1770272093331521536 |
spelling |
ftstandrewserep:oai:research-repository.st-andrews.ac.uk:10023/19511 2023-07-02T03:32:30+02:00 Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 Stokholm, Iben Härkönen, Tero Harding, Karin C. Siebert, Ursula Lehnert, Kristina Dietz, Rune Teilmann, Jonas Galatius, Anders Havmøller, Linnea Worsøe Carroll, Emma L. Hall, Ailsa Olsen, Morten Tange University of St Andrews. School of Biology University of St Andrews. Sea Mammal Research Unit University of St Andrews. Marine Alliance for Science & Technology Scotland University of St Andrews. Scottish Oceans Institute 2020-02-21 10 application/pdf http://hdl.handle.net/10023/19511 https://doi.org/10.3354/dao03328 eng eng Diseases of Aquatic Organisms Stokholm , I , Härkönen , T , Harding , K C , Siebert , U , Lehnert , K , Dietz , R , Teilmann , J , Galatius , A , Havmøller , L W , Carroll , E L , Hall , A & Olsen , M T 2019 , ' Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002 ' , Diseases of Aquatic Organisms , vol. 133 , no. 1 , pp. 47-56 . https://doi.org/10.3354/dao03328 0177-5103 PURE: 258965270 PURE UUID: 3e3fa66c-0d9e-4030-8890-1ea8da781c5c Scopus: 85064695144 ORCID: /0000-0002-7562-1771/work/57568152 WOS: 000483878800006 http://hdl.handle.net/10023/19511 https://doi.org/10.3354/dao03328 Copyright © 2019 Inter-Research. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.3354/dao03328 Epidemic Morbillivirus Viral phylogeny Virus evolution Wildlife pathogen GC Oceanography QH301 Biology Ecology Evolution Behavior and Systematics Aquatic Science NDAS SDG 10 - Reduced Inequalities SDG 14 - Life Below Water GC QH301 Journal article 2020 ftstandrewserep https://doi.org/10.3354/dao03328 2023-06-13T18:31:21Z The study was supported by the Villum Foundation, the Danish Ministry of the Environment, the Volkswagen Foundation (Az.: 89911) and the BONUS programme BaltHealth, which has received funding from BONUS (Art. 185), funded jointly by the EU, Innovation Fund Denmark (grants 6180-00001B and 6180-00002B), Forschungszentrum Jülich GmbH, German Federal Ministry of Education and Research (grant FKZ 03F0767A), Academy of Finland (grant 311966) and Swedish Foundation for Strategic Environmental Research (MISTRA). The 1988 and 2002 phocine distemper virus (PDV) outbreaks in European harbour seals Phoca vitulina are among the largest mass mortality events recorded in marine mammals. Despite its large impact on harbour seal population numbers, and 3 decades of studies, many questions regarding the spread and temporal origin of PDV remain unanswered. Here, we sequenced and analysed 7123 bp of the PDV genome, including the coding and non-coding regions of the entire P, M, F and H genes in tissues from 44 harbour seals to shed new light on the origin and spread of PDV in 1988 and 2002. The phylogenetic analyses trace the origin of the PDV strain causing the 1988 outbreak to between June 1987 and April 1988, while the origin of the strain causing the 2002 outbreak can be traced back to between July 2001 and April 2002. The analyses further point to several independent introductions of PDV in 1988, possibly linked to a southward mass immigration of harp seals in the winter and spring of 1987−1988. The vector for the 2002 outbreak is unknown, but the epidemiological analyses suggest the subsequent spread of PDV from the epicentre in the Kattegat, Denmark, to haul-out sites in the North Sea through several independent introductions. Postprint Peer reviewed Article in Journal/Newspaper harbour seal Phoca vitulina University of St Andrews: Digital Research Repository Kattegat ENVELOPE(9.692,9.692,63.563,63.563) Diseases of Aquatic Organisms 133 1 47 56 |