Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp M-207 Associated with the Deep-Sea Coral Lophelia pertusa

The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedit...

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Published in:Marine Drugs
Main Authors: Brana, Alfredo F., Sarmiento-Vizcaino, Aida, Osset, Miguel, Perez-Victoria, Ignacio, Martin, Jesus, de Pedro, Nuria, de la Cruz, Mercedes, Diaz, Caridad, Vicente, Francisca, Reyes, Fernando, Garcia, Luis A., Blanco, Gloria
Other Authors: Brana, Alfredo F. Univ Oviedo, Inst Univ Oncol Principado Asturias, Area Microbiol, Dept Biol, E-33006 Oviedo, Spain, Sarmiento-Vizcaino, Aida Univ Oviedo, Inst Univ Oncol Principado Asturias, Area Microbiol, Dept Biol, E-33006 Oviedo, Spain, Osset, Miguel Univ Oviedo, Inst Univ Oncol Principado Asturias, Area Microbiol, Dept Biol, E-33006 Oviedo, Spain, Blanco, Gloria Univ Oviedo, Inst Univ Oncol Principado Asturias, Area Microbiol, Dept Biol, E-33006 Oviedo, Spain, Perez-Victoria, Ignacio Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain, Martin, Jesus Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain, de Pedro, Nuria Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain, de la Cruz, Mercedes Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain, Diaz, Caridad Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain, Vicente, Francisca Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain, Reyes, Fernando Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain, Garcia, Luis A. Univ Oviedo, Area Ingn Quim, Dept Ingn Quim & Tecnol Medio Ambiente, Oviedo 33006, Spain, Universidad de Oviedo, Gobierno del Principado de Asturias, Ministerio de Ciencia e Innovacion
Format: Article in Journal/Newspaper
Language:English
Published: Mdpi 2017
Subjects:
lobophorins
spirotetronate antibiotic
Streptomyces
antitumor
Cantabrian Sea-derived actinobacteria
Spirotetronate antibiotics
Metabolites
Lophelia pertusa
Online Access:http://hdl.handle.net/10668/19298
https://doi.org/10.3390/md15050144
https://www.mdpi.com/1660-3397/15/5/144/pdf
Description
Summary:The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Aviles Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.

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