Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.
A cultivation-dependent approach revealed that highly diverse populations of Streptomyces were present in atmospheric precipitations from a hailstorm event sampled in February 2016 in the Cantabrian Sea coast, North of Spain. A total of 29 bioactive Streptomyces strains isolated from small samples o...
Published in: | Frontiers in Microbiology |
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Online Access: | http://hdl.handle.net/10668/12437 https://doi.org/10.3389/fmicb.2018.00773 https://www.frontiersin.org/articles/10.3389/fmicb.2018.00773/pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924784/pdf |
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ftsspa:oai:www.repositoriosalud.es:10668/12437 2023-11-12T04:13:39+01:00 Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products. Sarmiento-Vizcaíno, Aida Espadas, Julia Martín, Jesús Braña, Alfredo F Reyes, Fernando García, Luis A Blanco, Gloria 2018-04-23 application/pdf http://hdl.handle.net/10668/12437 https://doi.org/10.3389/fmicb.2018.00773 https://www.frontiersin.org/articles/10.3389/fmicb.2018.00773/pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924784/pdf en eng 1664-302X http://hdl.handle.net/10668/12437 29740412 doi:10.3389/fmicb.2018.00773 PMC5924784 https://www.frontiersin.org/articles/10.3389/fmicb.2018.00773/pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924784/pdf Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ open access Streptomyces antibiotic antimicrobial antitumor bioaerosols hailstorm research article VoR 2018 ftsspa https://doi.org/10.3389/fmicb.2018.00773 2023-10-29T17:31:12Z A cultivation-dependent approach revealed that highly diverse populations of Streptomyces were present in atmospheric precipitations from a hailstorm event sampled in February 2016 in the Cantabrian Sea coast, North of Spain. A total of 29 bioactive Streptomyces strains isolated from small samples of hailstone and rainwater, collected from this hailstorm event, were studied here. Taxonomic identification by 16S rRNA sequencing revealed more than 20 different Streptomyces species, with their closest homologs displaying mainly oceanic but also terrestrial origins. Backward trajectory analysis revealed that the air-mass sources of the hailstorm event, with North Western winds, were originated in the Arctic Ocean (West Greenland and North Iceland) and Canada (Labrador), depending on the altitude. After traveling across the North Atlantic Ocean during 4 days the air mass reached Europe and precipitated as hailstone and rain water at the sampling place in Spain. The finding of Streptomyces species able to survive and disperse through the atmosphere increases our knowledge of the biogeography of genus Streptomyces on Earth, and reinforces our previous dispersion model, suggesting a generalized feature for the genus which could have been essential in his evolution. This unique atmospheric-derived Streptomyces collection was screened for production of bioactive secondary metabolites. Analyses of isolates ethyl acetate extracts by LC-UV-MS and further database comparison revealed an extraordinary diversity of bioactive natural products. One hundred molecules were identified, mostly displaying contrasted antibiotic and antitumor/cytotoxic activities, but also antiparasitic, antiviral, anti-inflammatory, neuroprotector, and insecticide properties. More interestingly, 38 molecules not identified in natural products databases might represent new natural products. Our results revealed for the first time an extraordinary diversity of Streptomyces species in the atmosphere able to produce an extraordinary repertoire of bioactive ... Article in Journal/Newspaper Arctic Arctic Ocean Greenland Iceland North Atlantic Sistema Sanitario Público de Andalucía (SSPA): Repositorio Arctic Arctic Ocean Canada Greenland Frontiers in Microbiology 9 |
institution |
Open Polar |
collection |
Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
op_collection_id |
ftsspa |
language |
English |
topic |
Streptomyces antibiotic antimicrobial antitumor bioaerosols hailstorm |
spellingShingle |
Streptomyces antibiotic antimicrobial antitumor bioaerosols hailstorm Sarmiento-Vizcaíno, Aida Espadas, Julia Martín, Jesús Braña, Alfredo F Reyes, Fernando García, Luis A Blanco, Gloria Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products. |
topic_facet |
Streptomyces antibiotic antimicrobial antitumor bioaerosols hailstorm |
description |
A cultivation-dependent approach revealed that highly diverse populations of Streptomyces were present in atmospheric precipitations from a hailstorm event sampled in February 2016 in the Cantabrian Sea coast, North of Spain. A total of 29 bioactive Streptomyces strains isolated from small samples of hailstone and rainwater, collected from this hailstorm event, were studied here. Taxonomic identification by 16S rRNA sequencing revealed more than 20 different Streptomyces species, with their closest homologs displaying mainly oceanic but also terrestrial origins. Backward trajectory analysis revealed that the air-mass sources of the hailstorm event, with North Western winds, were originated in the Arctic Ocean (West Greenland and North Iceland) and Canada (Labrador), depending on the altitude. After traveling across the North Atlantic Ocean during 4 days the air mass reached Europe and precipitated as hailstone and rain water at the sampling place in Spain. The finding of Streptomyces species able to survive and disperse through the atmosphere increases our knowledge of the biogeography of genus Streptomyces on Earth, and reinforces our previous dispersion model, suggesting a generalized feature for the genus which could have been essential in his evolution. This unique atmospheric-derived Streptomyces collection was screened for production of bioactive secondary metabolites. Analyses of isolates ethyl acetate extracts by LC-UV-MS and further database comparison revealed an extraordinary diversity of bioactive natural products. One hundred molecules were identified, mostly displaying contrasted antibiotic and antitumor/cytotoxic activities, but also antiparasitic, antiviral, anti-inflammatory, neuroprotector, and insecticide properties. More interestingly, 38 molecules not identified in natural products databases might represent new natural products. Our results revealed for the first time an extraordinary diversity of Streptomyces species in the atmosphere able to produce an extraordinary repertoire of bioactive ... |
format |
Article in Journal/Newspaper |
author |
Sarmiento-Vizcaíno, Aida Espadas, Julia Martín, Jesús Braña, Alfredo F Reyes, Fernando García, Luis A Blanco, Gloria |
author_facet |
Sarmiento-Vizcaíno, Aida Espadas, Julia Martín, Jesús Braña, Alfredo F Reyes, Fernando García, Luis A Blanco, Gloria |
author_sort |
Sarmiento-Vizcaíno, Aida |
title |
Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products. |
title_short |
Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products. |
title_full |
Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products. |
title_fullStr |
Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products. |
title_full_unstemmed |
Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products. |
title_sort |
atmospheric precipitations, hailstone and rainwater, as a novel source of streptomyces producing bioactive natural products. |
publishDate |
2018 |
url |
http://hdl.handle.net/10668/12437 https://doi.org/10.3389/fmicb.2018.00773 https://www.frontiersin.org/articles/10.3389/fmicb.2018.00773/pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924784/pdf |
geographic |
Arctic Arctic Ocean Canada Greenland |
geographic_facet |
Arctic Arctic Ocean Canada Greenland |
genre |
Arctic Arctic Ocean Greenland Iceland North Atlantic |
genre_facet |
Arctic Arctic Ocean Greenland Iceland North Atlantic |
op_relation |
1664-302X http://hdl.handle.net/10668/12437 29740412 doi:10.3389/fmicb.2018.00773 PMC5924784 https://www.frontiersin.org/articles/10.3389/fmicb.2018.00773/pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924784/pdf |
op_rights |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ open access |
op_doi |
https://doi.org/10.3389/fmicb.2018.00773 |
container_title |
Frontiers in Microbiology |
container_volume |
9 |
_version_ |
1782331552740409344 |