Reproductive failure in UK harbour porpoises Phocoena phocoena : legacy of pollutant exposure?
Reproductive failure in mammals due to exposure to polychlorinated biphenyls (PCBs) can occur either through endocrine disrupting effects or via immunosuppression and increased disease risk. To investigate further, full necropsies and determination of summed 25 polychlorinated biphenyls congeners (∑...
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2015
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Online Access: | https://pure.sruc.ac.uk/en/publications/7bc9cadb-6c8c-454a-8e7d-75ac9ff032af https://doi.org/10.1371/journal.pone.0131085 https://pure.sruc.ac.uk/ws/files/14876768/14542.pdf |
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ftsrucpubl:oai:pure.atira.dk:publications/7bc9cadb-6c8c-454a-8e7d-75ac9ff032af 2024-04-28T08:31:54+00:00 Reproductive failure in UK harbour porpoises Phocoena phocoena : legacy of pollutant exposure? Murphy, S Barber, JL Learmonth, JA Read, FL Deaville, R Perkins, MW Brownlow, A Davison, N Penrose, R Pierce, GJ Law, RJ Jepson, PD 2015-07-22 application/pdf https://pure.sruc.ac.uk/en/publications/7bc9cadb-6c8c-454a-8e7d-75ac9ff032af https://doi.org/10.1371/journal.pone.0131085 https://pure.sruc.ac.uk/ws/files/14876768/14542.pdf eng eng https://pure.sruc.ac.uk/en/publications/7bc9cadb-6c8c-454a-8e7d-75ac9ff032af info:eu-repo/semantics/openAccess Murphy , S , Barber , JL , Learmonth , JA , Read , FL , Deaville , R , Perkins , MW , Brownlow , A , Davison , N , Penrose , R , Pierce , GJ , Law , RJ & Jepson , PD 2015 , ' Reproductive failure in UK harbour porpoises Phocoena phocoena : legacy of pollutant exposure? ' , PLoS ONE , vol. 10 , no. 7 , pp. 2 - 6 . https://doi.org/10.1371/journal.pone.0131085 Fetal death Infectious diseases Lipids Marine mammals Pollutants Porpoises Pregnancy Seals /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water article 2015 ftsrucpubl https://doi.org/10.1371/journal.pone.0131085 2024-04-02T17:02:12Z Reproductive failure in mammals due to exposure to polychlorinated biphenyls (PCBs) can occur either through endocrine disrupting effects or via immunosuppression and increased disease risk. To investigate further, full necropsies and determination of summed 25 polychlorinated biphenyls congeners (∑PCBs lipid weight) in blubber were undertaken on 329 UK-stranded female harbour porpoises (1990-2012). In sexually mature females, 25/127 (19.7%) showed direct evidence of reproductive failure (foetal death, aborting, dystocia or stillbirth). A further 21/127 (16.5%) had infections of the reproductive tract or tumours of reproductive tract tissues that could contribute to reproductive failure. Resting mature females (non-lactating or non-pregnant) had significantly higher mean ∑PCBs (18.5 mg/kg) than both lactating (7.5 mg/kg) and pregnant females (6 mg/kg), though not significantly different to sexually immature females (14.0 mg/kg). Using multinomial logistic regression models ΣPCBs was found to be a significant predictor of mature female reproductive status, adjusting for the effects of confounding variables. Resting females were more likely to have a higher PCB burden. Health status (proxied by “trauma” or “infectious disease” causes of death) was also a significant predictor, with lactating females (i.e. who successfully reproduced) more likely to be in good health status compared to other individuals. Based on contaminant profiles (>11 mg/kg lipid), at least 29/60 (48%) of resting females had not offloaded their pollutant burden via gestation and primarily lactation. Where data were available, these non-offloading females were previously gravid, which suggests foetal or newborn mortality. Furthermore, a lower pregnancy rate of 50% was estimated for “healthy” females that died of traumatic causes of death, compared to other populations. Whether or not PCBs are part of an underlying mechanism, we used individual PCB burdens to show further evidence of reproductive failure in the North-east Atlantic harbour ... Article in Journal/Newspaper North East Atlantic Phocoena phocoena SRUC (Scotland's Rural College): Research Portal PLOS ONE 10 7 e0131085 |
institution |
Open Polar |
collection |
SRUC (Scotland's Rural College): Research Portal |
op_collection_id |
ftsrucpubl |
language |
English |
topic |
Fetal death Infectious diseases Lipids Marine mammals Pollutants Porpoises Pregnancy Seals /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water |
spellingShingle |
Fetal death Infectious diseases Lipids Marine mammals Pollutants Porpoises Pregnancy Seals /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water Murphy, S Barber, JL Learmonth, JA Read, FL Deaville, R Perkins, MW Brownlow, A Davison, N Penrose, R Pierce, GJ Law, RJ Jepson, PD Reproductive failure in UK harbour porpoises Phocoena phocoena : legacy of pollutant exposure? |
topic_facet |
Fetal death Infectious diseases Lipids Marine mammals Pollutants Porpoises Pregnancy Seals /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water |
description |
Reproductive failure in mammals due to exposure to polychlorinated biphenyls (PCBs) can occur either through endocrine disrupting effects or via immunosuppression and increased disease risk. To investigate further, full necropsies and determination of summed 25 polychlorinated biphenyls congeners (∑PCBs lipid weight) in blubber were undertaken on 329 UK-stranded female harbour porpoises (1990-2012). In sexually mature females, 25/127 (19.7%) showed direct evidence of reproductive failure (foetal death, aborting, dystocia or stillbirth). A further 21/127 (16.5%) had infections of the reproductive tract or tumours of reproductive tract tissues that could contribute to reproductive failure. Resting mature females (non-lactating or non-pregnant) had significantly higher mean ∑PCBs (18.5 mg/kg) than both lactating (7.5 mg/kg) and pregnant females (6 mg/kg), though not significantly different to sexually immature females (14.0 mg/kg). Using multinomial logistic regression models ΣPCBs was found to be a significant predictor of mature female reproductive status, adjusting for the effects of confounding variables. Resting females were more likely to have a higher PCB burden. Health status (proxied by “trauma” or “infectious disease” causes of death) was also a significant predictor, with lactating females (i.e. who successfully reproduced) more likely to be in good health status compared to other individuals. Based on contaminant profiles (>11 mg/kg lipid), at least 29/60 (48%) of resting females had not offloaded their pollutant burden via gestation and primarily lactation. Where data were available, these non-offloading females were previously gravid, which suggests foetal or newborn mortality. Furthermore, a lower pregnancy rate of 50% was estimated for “healthy” females that died of traumatic causes of death, compared to other populations. Whether or not PCBs are part of an underlying mechanism, we used individual PCB burdens to show further evidence of reproductive failure in the North-east Atlantic harbour ... |
format |
Article in Journal/Newspaper |
author |
Murphy, S Barber, JL Learmonth, JA Read, FL Deaville, R Perkins, MW Brownlow, A Davison, N Penrose, R Pierce, GJ Law, RJ Jepson, PD |
author_facet |
Murphy, S Barber, JL Learmonth, JA Read, FL Deaville, R Perkins, MW Brownlow, A Davison, N Penrose, R Pierce, GJ Law, RJ Jepson, PD |
author_sort |
Murphy, S |
title |
Reproductive failure in UK harbour porpoises Phocoena phocoena : legacy of pollutant exposure? |
title_short |
Reproductive failure in UK harbour porpoises Phocoena phocoena : legacy of pollutant exposure? |
title_full |
Reproductive failure in UK harbour porpoises Phocoena phocoena : legacy of pollutant exposure? |
title_fullStr |
Reproductive failure in UK harbour porpoises Phocoena phocoena : legacy of pollutant exposure? |
title_full_unstemmed |
Reproductive failure in UK harbour porpoises Phocoena phocoena : legacy of pollutant exposure? |
title_sort |
reproductive failure in uk harbour porpoises phocoena phocoena : legacy of pollutant exposure? |
publishDate |
2015 |
url |
https://pure.sruc.ac.uk/en/publications/7bc9cadb-6c8c-454a-8e7d-75ac9ff032af https://doi.org/10.1371/journal.pone.0131085 https://pure.sruc.ac.uk/ws/files/14876768/14542.pdf |
genre |
North East Atlantic Phocoena phocoena |
genre_facet |
North East Atlantic Phocoena phocoena |
op_source |
Murphy , S , Barber , JL , Learmonth , JA , Read , FL , Deaville , R , Perkins , MW , Brownlow , A , Davison , N , Penrose , R , Pierce , GJ , Law , RJ & Jepson , PD 2015 , ' Reproductive failure in UK harbour porpoises Phocoena phocoena : legacy of pollutant exposure? ' , PLoS ONE , vol. 10 , no. 7 , pp. 2 - 6 . https://doi.org/10.1371/journal.pone.0131085 |
op_relation |
https://pure.sruc.ac.uk/en/publications/7bc9cadb-6c8c-454a-8e7d-75ac9ff032af |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0131085 |
container_title |
PLOS ONE |
container_volume |
10 |
container_issue |
7 |
container_start_page |
e0131085 |
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