Neisseria meningitidis sequence type and risk for death, Iceland
Invasive meningococcal infections are hyperendemic in Iceland, a relatively isolated country in the mid-Atlantic. We performed a nationwide study on all viable meningococcal strains (N = 362) from 1977 to 2004. We analyzed the association of patient's age and sex, meningococcal serogroups, and...
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ftsouthampton:oai:eprints.soton.ac.uk:152843 2023-07-30T04:04:19+02:00 Neisseria meningitidis sequence type and risk for death, Iceland Gottfredsson, Magnus Diggle, Mathew A. Lawrie, David I. Erlendsdottir, Helga Hardarottir, Hjordis Kristinsson,, Karl G Clarke, Stuart C. 2006-07 text https://eprints.soton.ac.uk/152843/ https://eprints.soton.ac.uk/152843/1/05-1624.pdf http://www.cdc.gov/ncidod/EID/vol12no07/pdfs/vol12no07.pdf en eng https://eprints.soton.ac.uk/152843/1/05-1624.pdf Gottfredsson, Magnus, Diggle, Mathew A., Lawrie, David I., Erlendsdottir, Helga, Hardarottir, Hjordis, Kristinsson,, Karl G and Clarke, Stuart C. (2006) Neisseria meningitidis sequence type and risk for death, Iceland. Emerging Infectious Diseases, 12 (7), 1066-1073. Article PeerReviewed 2006 ftsouthampton 2023-07-09T21:16:33Z Invasive meningococcal infections are hyperendemic in Iceland, a relatively isolated country in the mid-Atlantic. We performed a nationwide study on all viable meningococcal strains (N = 362) from 1977 to 2004. We analyzed the association of patient's age and sex, meningococcal serogroups, and sequence types (STs) with outcomes. Overall, 59 different STs were identified, 19 of which were unique to Iceland. The most common STs were 32 (24.6%), 11 (19.9%), and 10 (10.2%). The unique ST-3492 ranked fourth (7.7%). The most common serogroups were B (56.4%), C (39.8%), and A (2.2%). Age (p < 0.001) and infection with a unique ST (p = 0.011) were independently associated with increased death rates, whereas isolation of meningococci from cerebrospinal fluid only was associated with lower death rates (p = 0.046). This study shows evolutionary trends of meningococcal isolates in a relatively isolated community and highlights an association between unique STs and poor outcome. Article in Journal/Newspaper Iceland University of Southampton: e-Prints Soton |
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University of Southampton: e-Prints Soton |
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ftsouthampton |
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English |
description |
Invasive meningococcal infections are hyperendemic in Iceland, a relatively isolated country in the mid-Atlantic. We performed a nationwide study on all viable meningococcal strains (N = 362) from 1977 to 2004. We analyzed the association of patient's age and sex, meningococcal serogroups, and sequence types (STs) with outcomes. Overall, 59 different STs were identified, 19 of which were unique to Iceland. The most common STs were 32 (24.6%), 11 (19.9%), and 10 (10.2%). The unique ST-3492 ranked fourth (7.7%). The most common serogroups were B (56.4%), C (39.8%), and A (2.2%). Age (p < 0.001) and infection with a unique ST (p = 0.011) were independently associated with increased death rates, whereas isolation of meningococci from cerebrospinal fluid only was associated with lower death rates (p = 0.046). This study shows evolutionary trends of meningococcal isolates in a relatively isolated community and highlights an association between unique STs and poor outcome. |
format |
Article in Journal/Newspaper |
author |
Gottfredsson, Magnus Diggle, Mathew A. Lawrie, David I. Erlendsdottir, Helga Hardarottir, Hjordis Kristinsson,, Karl G Clarke, Stuart C. |
spellingShingle |
Gottfredsson, Magnus Diggle, Mathew A. Lawrie, David I. Erlendsdottir, Helga Hardarottir, Hjordis Kristinsson,, Karl G Clarke, Stuart C. Neisseria meningitidis sequence type and risk for death, Iceland |
author_facet |
Gottfredsson, Magnus Diggle, Mathew A. Lawrie, David I. Erlendsdottir, Helga Hardarottir, Hjordis Kristinsson,, Karl G Clarke, Stuart C. |
author_sort |
Gottfredsson, Magnus |
title |
Neisseria meningitidis sequence type and risk for death, Iceland |
title_short |
Neisseria meningitidis sequence type and risk for death, Iceland |
title_full |
Neisseria meningitidis sequence type and risk for death, Iceland |
title_fullStr |
Neisseria meningitidis sequence type and risk for death, Iceland |
title_full_unstemmed |
Neisseria meningitidis sequence type and risk for death, Iceland |
title_sort |
neisseria meningitidis sequence type and risk for death, iceland |
publishDate |
2006 |
url |
https://eprints.soton.ac.uk/152843/ https://eprints.soton.ac.uk/152843/1/05-1624.pdf http://www.cdc.gov/ncidod/EID/vol12no07/pdfs/vol12no07.pdf |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
https://eprints.soton.ac.uk/152843/1/05-1624.pdf Gottfredsson, Magnus, Diggle, Mathew A., Lawrie, David I., Erlendsdottir, Helga, Hardarottir, Hjordis, Kristinsson,, Karl G and Clarke, Stuart C. (2006) Neisseria meningitidis sequence type and risk for death, Iceland. Emerging Infectious Diseases, 12 (7), 1066-1073. |
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