A Novel Dop2/Invertebrate-Type Dopamine Signaling System Potentially Mediates Stress, Female Reproduction, and Early Development in the Pacific Oyster (Crassostrea gigas)
International audience The dopaminergic signaling pathway is involved in many physiological functions in vertebrates, but poorly documented in protostome species except arthropods. We functionally characterized a novel dopamine receptor in the Pacific oyster (Crassostrea gigas), activated by dopamin...
Published in: | Marine Biotechnology |
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2021
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Online Access: | https://hal.science/hal-03327466 https://hal.science/hal-03327466/document https://hal.science/hal-03327466/file/Schwartz2021_Article_ANovelDop2Invertebrate-TypeDop.pdf https://doi.org/10.1007/s10126-021-10052-5 |
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ftsorbonneuniv:oai:HAL:hal-03327466v1 2023-12-17T10:29:05+01:00 A Novel Dop2/Invertebrate-Type Dopamine Signaling System Potentially Mediates Stress, Female Reproduction, and Early Development in the Pacific Oyster (Crassostrea gigas) Schwartz, Julie Réalis-Doyelle, Emilie Le Franc, Lorane Favrel, Pascal Biologie des Organismes et Ecosystèmes Aquatiques (BOREA) Université de Caen Normandie (UNICAEN) Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA) 2021-08-07 https://hal.science/hal-03327466 https://hal.science/hal-03327466/document https://hal.science/hal-03327466/file/Schwartz2021_Article_ANovelDop2Invertebrate-TypeDop.pdf https://doi.org/10.1007/s10126-021-10052-5 en eng HAL CCSD Springer Verlag info:eu-repo/semantics/altIdentifier/doi/10.1007/s10126-021-10052-5 hal-03327466 https://hal.science/hal-03327466 https://hal.science/hal-03327466/document https://hal.science/hal-03327466/file/Schwartz2021_Article_ANovelDop2Invertebrate-TypeDop.pdf doi:10.1007/s10126-021-10052-5 info:eu-repo/semantics/OpenAccess ISSN: 1436-2228 EISSN: 1436-2236 Marine Biotechnology https://hal.science/hal-03327466 Marine Biotechnology, 2021, ⟨10.1007/s10126-021-10052-5⟩ Dopamine receptor Tyramine receptor Dop2/INDR Mollusk Osmotic stress Reproduction [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2021 ftsorbonneuniv https://doi.org/10.1007/s10126-021-10052-5 2023-11-21T23:46:33Z International audience The dopaminergic signaling pathway is involved in many physiological functions in vertebrates, but poorly documented in protostome species except arthropods. We functionally characterized a novel dopamine receptor in the Pacific oyster (Crassostrea gigas), activated by dopamine and tyramine with different efficacy and potency orders. This receptor-Cragi-DOP2R-belongs to the D 1-like family of receptors and corresponds to the first representative of the Dop2/invertebratetype dopamine receptor (Dop2/INDR) group ever identified in Lophotrochozoa. Cragi-DOP2R transcripts were expressed in various adult tissues, with higher expression levels in the visceral ganglia and the gills. Following an experiment under acute osmotic conditions, Cragi-DOP2R transcripts significantly increased in the visceral ganglia and decreased in the gills, suggesting a role of dopamine signaling in the mediation of osmotic stress. Furthermore, a role of the Cragi-DOP2R signaling pathway in female gametogenesis and in early oyster development was strongly suggested by the significantly higher levels of receptor transcripts in mature female gonads and in the early embryonic stages. Article in Journal/Newspaper Crassostrea gigas Pacific oyster HAL Sorbonne Université Pacific Marine Biotechnology |
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Open Polar |
collection |
HAL Sorbonne Université |
op_collection_id |
ftsorbonneuniv |
language |
English |
topic |
Dopamine receptor Tyramine receptor Dop2/INDR Mollusk Osmotic stress Reproduction [SDV]Life Sciences [q-bio] |
spellingShingle |
Dopamine receptor Tyramine receptor Dop2/INDR Mollusk Osmotic stress Reproduction [SDV]Life Sciences [q-bio] Schwartz, Julie Réalis-Doyelle, Emilie Le Franc, Lorane Favrel, Pascal A Novel Dop2/Invertebrate-Type Dopamine Signaling System Potentially Mediates Stress, Female Reproduction, and Early Development in the Pacific Oyster (Crassostrea gigas) |
topic_facet |
Dopamine receptor Tyramine receptor Dop2/INDR Mollusk Osmotic stress Reproduction [SDV]Life Sciences [q-bio] |
description |
International audience The dopaminergic signaling pathway is involved in many physiological functions in vertebrates, but poorly documented in protostome species except arthropods. We functionally characterized a novel dopamine receptor in the Pacific oyster (Crassostrea gigas), activated by dopamine and tyramine with different efficacy and potency orders. This receptor-Cragi-DOP2R-belongs to the D 1-like family of receptors and corresponds to the first representative of the Dop2/invertebratetype dopamine receptor (Dop2/INDR) group ever identified in Lophotrochozoa. Cragi-DOP2R transcripts were expressed in various adult tissues, with higher expression levels in the visceral ganglia and the gills. Following an experiment under acute osmotic conditions, Cragi-DOP2R transcripts significantly increased in the visceral ganglia and decreased in the gills, suggesting a role of dopamine signaling in the mediation of osmotic stress. Furthermore, a role of the Cragi-DOP2R signaling pathway in female gametogenesis and in early oyster development was strongly suggested by the significantly higher levels of receptor transcripts in mature female gonads and in the early embryonic stages. |
author2 |
Biologie des Organismes et Ecosystèmes Aquatiques (BOREA) Université de Caen Normandie (UNICAEN) Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA) |
format |
Article in Journal/Newspaper |
author |
Schwartz, Julie Réalis-Doyelle, Emilie Le Franc, Lorane Favrel, Pascal |
author_facet |
Schwartz, Julie Réalis-Doyelle, Emilie Le Franc, Lorane Favrel, Pascal |
author_sort |
Schwartz, Julie |
title |
A Novel Dop2/Invertebrate-Type Dopamine Signaling System Potentially Mediates Stress, Female Reproduction, and Early Development in the Pacific Oyster (Crassostrea gigas) |
title_short |
A Novel Dop2/Invertebrate-Type Dopamine Signaling System Potentially Mediates Stress, Female Reproduction, and Early Development in the Pacific Oyster (Crassostrea gigas) |
title_full |
A Novel Dop2/Invertebrate-Type Dopamine Signaling System Potentially Mediates Stress, Female Reproduction, and Early Development in the Pacific Oyster (Crassostrea gigas) |
title_fullStr |
A Novel Dop2/Invertebrate-Type Dopamine Signaling System Potentially Mediates Stress, Female Reproduction, and Early Development in the Pacific Oyster (Crassostrea gigas) |
title_full_unstemmed |
A Novel Dop2/Invertebrate-Type Dopamine Signaling System Potentially Mediates Stress, Female Reproduction, and Early Development in the Pacific Oyster (Crassostrea gigas) |
title_sort |
novel dop2/invertebrate-type dopamine signaling system potentially mediates stress, female reproduction, and early development in the pacific oyster (crassostrea gigas) |
publisher |
HAL CCSD |
publishDate |
2021 |
url |
https://hal.science/hal-03327466 https://hal.science/hal-03327466/document https://hal.science/hal-03327466/file/Schwartz2021_Article_ANovelDop2Invertebrate-TypeDop.pdf https://doi.org/10.1007/s10126-021-10052-5 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
ISSN: 1436-2228 EISSN: 1436-2236 Marine Biotechnology https://hal.science/hal-03327466 Marine Biotechnology, 2021, ⟨10.1007/s10126-021-10052-5⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10126-021-10052-5 hal-03327466 https://hal.science/hal-03327466 https://hal.science/hal-03327466/document https://hal.science/hal-03327466/file/Schwartz2021_Article_ANovelDop2Invertebrate-TypeDop.pdf doi:10.1007/s10126-021-10052-5 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1007/s10126-021-10052-5 |
container_title |
Marine Biotechnology |
_version_ |
1785581364749271040 |