Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution
International audience Thyroid-stimulating hormone (TSH) is composed of a specific b subunit and an a subunit that is shared with the two pituitary gonadotropins. The three b subunits derive from a common ancestral gene through two genome duplications (1R and 2R) that took place before the radiation...
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ftsorbonneuniv:oai:HAL:hal-01366759v1 2024-05-19T07:39:55+00:00 Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution Maugars, Gersende Dufour, Sylvie Cohen-Tannoudji, Joëlle Quérat, Bruno Biologie des Organismes et Ecosystèmes Aquatiques (BOREA) Université de Caen Normandie (UNICAEN) Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA) Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)) Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) 2014 https://hal.sorbonne-universite.fr/hal-01366759 https://hal.sorbonne-universite.fr/hal-01366759/document https://hal.sorbonne-universite.fr/hal-01366759/file/journal.pone.0111361.PDF https://doi.org/10.1371/journal.pone.0111361 en eng HAL CCSD Public Library of Science info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0111361 hal-01366759 https://hal.sorbonne-universite.fr/hal-01366759 https://hal.sorbonne-universite.fr/hal-01366759/document https://hal.sorbonne-universite.fr/hal-01366759/file/journal.pone.0111361.PDF doi:10.1371/journal.pone.0111361 http://creativecommons.org/licenses/by/ info:eu-repo/semantics/OpenAccess ISSN: 1932-6203 EISSN: 1932-6203 PLoS ONE https://hal.sorbonne-universite.fr/hal-01366759 PLoS ONE, 2014, 9 (11), pp.e111361. ⟨10.1371/journal.pone.0111361⟩ [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology info:eu-repo/semantics/article Journal articles 2014 ftsorbonneuniv https://doi.org/10.1371/journal.pone.0111361 2024-04-25T04:14:12Z International audience Thyroid-stimulating hormone (TSH) is composed of a specific b subunit and an a subunit that is shared with the two pituitary gonadotropins. The three b subunits derive from a common ancestral gene through two genome duplications (1R and 2R) that took place before the radiation of vertebrates. Analysis of genomic data from phylogenetically relevant species allowed us to identify an additional Tshb subunit-related gene that was generated through 2R. This gene, named Tshb2, present in cartilaginous fish, little skate and elephant shark, and in early lobe-finned fish, coelacanth and lungfish, was lost in ray-finned fish and tetrapods. The absence of a second type of TSH receptor (Tshr) gene in these species suggests that both TSHs act through the same receptor. A novel Tshb sister gene, named Tshb3, was generated through the third genomic duplication (3R) that occurred early in the teleost lineage. Tshb3 is present in most teleost groups but was lostin tedraodontiforms. The 3R also generated a second Tshr, named Tshrb. Interestingly, the new Tshrb was translocated from its original chromosomic position after the emergence of eels and was then maintained in its new position. Tshrb was lost in tetraodontiforms and in ostariophysians including zebrafish although the latter species have two TSHs, suggesting that TSHRb may be dispensable. The tissue distribution of duplicated Tshbs and Tshrs was studied in the European eel. The endocrine thyrotropic function in the eel would be essentially mediated by the classical Tshb and Tshra, which are mainly expressed in the pituitary and thyroid, respectively. Tshb3 and Tshrb showed a similar distribution pattern in the brain, pituitary, ovary and adipose tissue, suggesting a possible paracrine/autocrine mode of action in these non-thyroidal tissues. Further studies will be needed to determine the binding specificity of the two receptors and how these two TSH systems are interrelated. Article in Journal/Newspaper European eel HAL Sorbonne Université PLoS ONE 9 11 e111361 |
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Open Polar |
collection |
HAL Sorbonne Université |
op_collection_id |
ftsorbonneuniv |
language |
English |
topic |
[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology |
spellingShingle |
[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology Maugars, Gersende Dufour, Sylvie Cohen-Tannoudji, Joëlle Quérat, Bruno Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution |
topic_facet |
[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology |
description |
International audience Thyroid-stimulating hormone (TSH) is composed of a specific b subunit and an a subunit that is shared with the two pituitary gonadotropins. The three b subunits derive from a common ancestral gene through two genome duplications (1R and 2R) that took place before the radiation of vertebrates. Analysis of genomic data from phylogenetically relevant species allowed us to identify an additional Tshb subunit-related gene that was generated through 2R. This gene, named Tshb2, present in cartilaginous fish, little skate and elephant shark, and in early lobe-finned fish, coelacanth and lungfish, was lost in ray-finned fish and tetrapods. The absence of a second type of TSH receptor (Tshr) gene in these species suggests that both TSHs act through the same receptor. A novel Tshb sister gene, named Tshb3, was generated through the third genomic duplication (3R) that occurred early in the teleost lineage. Tshb3 is present in most teleost groups but was lostin tedraodontiforms. The 3R also generated a second Tshr, named Tshrb. Interestingly, the new Tshrb was translocated from its original chromosomic position after the emergence of eels and was then maintained in its new position. Tshrb was lost in tetraodontiforms and in ostariophysians including zebrafish although the latter species have two TSHs, suggesting that TSHRb may be dispensable. The tissue distribution of duplicated Tshbs and Tshrs was studied in the European eel. The endocrine thyrotropic function in the eel would be essentially mediated by the classical Tshb and Tshra, which are mainly expressed in the pituitary and thyroid, respectively. Tshb3 and Tshrb showed a similar distribution pattern in the brain, pituitary, ovary and adipose tissue, suggesting a possible paracrine/autocrine mode of action in these non-thyroidal tissues. Further studies will be needed to determine the binding specificity of the two receptors and how these two TSH systems are interrelated. |
author2 |
Biologie des Organismes et Ecosystèmes Aquatiques (BOREA) Université de Caen Normandie (UNICAEN) Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA) Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)) Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
format |
Article in Journal/Newspaper |
author |
Maugars, Gersende Dufour, Sylvie Cohen-Tannoudji, Joëlle Quérat, Bruno |
author_facet |
Maugars, Gersende Dufour, Sylvie Cohen-Tannoudji, Joëlle Quérat, Bruno |
author_sort |
Maugars, Gersende |
title |
Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution |
title_short |
Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution |
title_full |
Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution |
title_fullStr |
Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution |
title_full_unstemmed |
Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution |
title_sort |
multiple thyrotropin β-subunit and thyrotropin receptor-related genes arose during vertebrate evolution |
publisher |
HAL CCSD |
publishDate |
2014 |
url |
https://hal.sorbonne-universite.fr/hal-01366759 https://hal.sorbonne-universite.fr/hal-01366759/document https://hal.sorbonne-universite.fr/hal-01366759/file/journal.pone.0111361.PDF https://doi.org/10.1371/journal.pone.0111361 |
genre |
European eel |
genre_facet |
European eel |
op_source |
ISSN: 1932-6203 EISSN: 1932-6203 PLoS ONE https://hal.sorbonne-universite.fr/hal-01366759 PLoS ONE, 2014, 9 (11), pp.e111361. ⟨10.1371/journal.pone.0111361⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0111361 hal-01366759 https://hal.sorbonne-universite.fr/hal-01366759 https://hal.sorbonne-universite.fr/hal-01366759/document https://hal.sorbonne-universite.fr/hal-01366759/file/journal.pone.0111361.PDF doi:10.1371/journal.pone.0111361 |
op_rights |
http://creativecommons.org/licenses/by/ info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0111361 |
container_title |
PLoS ONE |
container_volume |
9 |
container_issue |
11 |
container_start_page |
e111361 |
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1799479498025992192 |