Dopamine inhibits luteinizing hormone synthesis and release in the juvenile European eel: a neuroendocrine lock for the onset of puberty.
In various adult teleost fishes, LH ovulatory peak is under a dual neurohormonal control that is stimulatory by GnRH and inhibitory by dopamine (DA). We investigated whether DA could also be involved in the inhibitory control of LH at earlier steps of gametogenesis by studying the model of the Europ...
Published in: | Biology of Reproduction |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Online Access: | https://hal.science/hal-00121615 https://doi.org/10.1095/biolreprod.104.030627 |
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ftsorbonneuniv:oai:HAL:hal-00121615v1 2023-06-11T04:03:47+02:00 Dopamine inhibits luteinizing hormone synthesis and release in the juvenile European eel: a neuroendocrine lock for the onset of puberty. Vidal, Bernadette Pasqualini, Catherine Le Belle, Nadine Holland, M Claire H Sbaihi, Miskal Vernier, Philippe Zohar, Yonathan Dufour, Sylvie Biologie des organismes marins et écosystèmes (BOME) Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS) Développement, évolution et plasticité du système nerveux (DEPSN) Centre National de la Recherche Scientifique (CNRS) Institut de Neurobiologie Alfred Fessard (INAF) Biotechnology Institute University of Maryland Baltimore County (UMBC) University of Maryland System-University of Maryland System 2004-11 https://hal.science/hal-00121615 https://doi.org/10.1095/biolreprod.104.030627 en eng HAL CCSD Society for the Study of Reproduction info:eu-repo/semantics/altIdentifier/doi/10.1095/biolreprod.104.030627 info:eu-repo/semantics/altIdentifier/pmid/15229141 hal-00121615 https://hal.science/hal-00121615 doi:10.1095/biolreprod.104.030627 PUBMED: 15229141 ISSN: 0006-3363 EISSN: 1529-7268 Biology of Reproduction https://hal.science/hal-00121615 Biology of Reproduction, 2004, 71 (5), pp.1491-500. ⟨10.1095/biolreprod.104.030627⟩ MESH: Animals MESH: Biometry MESH: Genitalia MESH: Gonadotropin-Releasing Hormone MESH: Gonadotropins MESH: Liver MESH: Luteinizing Hormone MESH: Neurosecretory Systems MESH: Organ Size MESH: Ovary MESH: Pimozide MESH: Pituitary Gland MESH: Body Weight MESH: Puberty MESH: Testosterone MESH: Tyrosine 3-Monooxygenase MESH: Brain MESH: Dopamine MESH: Dopamine Antagonists MESH: Eels MESH: Endocrine Glands MESH: Female MESH: Gastrointestinal Tract [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] info:eu-repo/semantics/article Journal articles 2004 ftsorbonneuniv https://doi.org/10.1095/biolreprod.104.030627 2023-05-30T00:34:20Z In various adult teleost fishes, LH ovulatory peak is under a dual neurohormonal control that is stimulatory by GnRH and inhibitory by dopamine (DA). We investigated whether DA could also be involved in the inhibitory control of LH at earlier steps of gametogenesis by studying the model of the European eel, Anguilla anguilla, which remains at a prepubertal stage until the oceanic reproductive migration. According to a protocol previously developed in the striped bass, eels received sustained treatments with GnRH agonist (GnRHa), DA-receptor antagonist (pimozide), and testosterone (T) either alone or in combination. Only the triple treatment with T, GnRHa, and pimozide could trigger dramatic increases in LH synthesis and release as well as in plasma vitellogenin levels and a stimulation of ovarian vitellogenesis. Thus, in the prepubertal eel, removal of DA inhibition is required for triggering GnRH-stimulated LH synthesis and release as well as ovarian development. To locate the anatomical support for DA inhibition, the distribution of tyrosine hydroxylase (TH) in the brain and pituitary was studied by immunocytochemistry. Numerous TH-immunoreactive cell bodies were observed in the preoptic anteroventral nucleus, with a dense tract of immunoreactive fibers reaching the pituitary proximal pars distalis, where the gonadotrophs are located. This pathway corresponds to that mediating the inhibition of LH and ovulation in adult teleosts. To our knowledge, this is the first demonstration of a pivotal role for DA in the control of LH and puberty in a juvenile teleost. These data support the view that DA inhibition on LH secretion is an ancient evolutionary component in the neuroendocrine regulation of reproduction that may have been partially maintained throughout vertebrate evolution. Article in Journal/Newspaper Anguilla anguilla HAL Sorbonne Université Biology of Reproduction 71 5 1491 1500 |
institution |
Open Polar |
collection |
HAL Sorbonne Université |
op_collection_id |
ftsorbonneuniv |
language |
English |
topic |
MESH: Animals MESH: Biometry MESH: Genitalia MESH: Gonadotropin-Releasing Hormone MESH: Gonadotropins MESH: Liver MESH: Luteinizing Hormone MESH: Neurosecretory Systems MESH: Organ Size MESH: Ovary MESH: Pimozide MESH: Pituitary Gland MESH: Body Weight MESH: Puberty MESH: Testosterone MESH: Tyrosine 3-Monooxygenase MESH: Brain MESH: Dopamine MESH: Dopamine Antagonists MESH: Eels MESH: Endocrine Glands MESH: Female MESH: Gastrointestinal Tract [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
spellingShingle |
MESH: Animals MESH: Biometry MESH: Genitalia MESH: Gonadotropin-Releasing Hormone MESH: Gonadotropins MESH: Liver MESH: Luteinizing Hormone MESH: Neurosecretory Systems MESH: Organ Size MESH: Ovary MESH: Pimozide MESH: Pituitary Gland MESH: Body Weight MESH: Puberty MESH: Testosterone MESH: Tyrosine 3-Monooxygenase MESH: Brain MESH: Dopamine MESH: Dopamine Antagonists MESH: Eels MESH: Endocrine Glands MESH: Female MESH: Gastrointestinal Tract [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Vidal, Bernadette Pasqualini, Catherine Le Belle, Nadine Holland, M Claire H Sbaihi, Miskal Vernier, Philippe Zohar, Yonathan Dufour, Sylvie Dopamine inhibits luteinizing hormone synthesis and release in the juvenile European eel: a neuroendocrine lock for the onset of puberty. |
topic_facet |
MESH: Animals MESH: Biometry MESH: Genitalia MESH: Gonadotropin-Releasing Hormone MESH: Gonadotropins MESH: Liver MESH: Luteinizing Hormone MESH: Neurosecretory Systems MESH: Organ Size MESH: Ovary MESH: Pimozide MESH: Pituitary Gland MESH: Body Weight MESH: Puberty MESH: Testosterone MESH: Tyrosine 3-Monooxygenase MESH: Brain MESH: Dopamine MESH: Dopamine Antagonists MESH: Eels MESH: Endocrine Glands MESH: Female MESH: Gastrointestinal Tract [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
description |
In various adult teleost fishes, LH ovulatory peak is under a dual neurohormonal control that is stimulatory by GnRH and inhibitory by dopamine (DA). We investigated whether DA could also be involved in the inhibitory control of LH at earlier steps of gametogenesis by studying the model of the European eel, Anguilla anguilla, which remains at a prepubertal stage until the oceanic reproductive migration. According to a protocol previously developed in the striped bass, eels received sustained treatments with GnRH agonist (GnRHa), DA-receptor antagonist (pimozide), and testosterone (T) either alone or in combination. Only the triple treatment with T, GnRHa, and pimozide could trigger dramatic increases in LH synthesis and release as well as in plasma vitellogenin levels and a stimulation of ovarian vitellogenesis. Thus, in the prepubertal eel, removal of DA inhibition is required for triggering GnRH-stimulated LH synthesis and release as well as ovarian development. To locate the anatomical support for DA inhibition, the distribution of tyrosine hydroxylase (TH) in the brain and pituitary was studied by immunocytochemistry. Numerous TH-immunoreactive cell bodies were observed in the preoptic anteroventral nucleus, with a dense tract of immunoreactive fibers reaching the pituitary proximal pars distalis, where the gonadotrophs are located. This pathway corresponds to that mediating the inhibition of LH and ovulation in adult teleosts. To our knowledge, this is the first demonstration of a pivotal role for DA in the control of LH and puberty in a juvenile teleost. These data support the view that DA inhibition on LH secretion is an ancient evolutionary component in the neuroendocrine regulation of reproduction that may have been partially maintained throughout vertebrate evolution. |
author2 |
Biologie des organismes marins et écosystèmes (BOME) Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS) Développement, évolution et plasticité du système nerveux (DEPSN) Centre National de la Recherche Scientifique (CNRS) Institut de Neurobiologie Alfred Fessard (INAF) Biotechnology Institute University of Maryland Baltimore County (UMBC) University of Maryland System-University of Maryland System |
format |
Article in Journal/Newspaper |
author |
Vidal, Bernadette Pasqualini, Catherine Le Belle, Nadine Holland, M Claire H Sbaihi, Miskal Vernier, Philippe Zohar, Yonathan Dufour, Sylvie |
author_facet |
Vidal, Bernadette Pasqualini, Catherine Le Belle, Nadine Holland, M Claire H Sbaihi, Miskal Vernier, Philippe Zohar, Yonathan Dufour, Sylvie |
author_sort |
Vidal, Bernadette |
title |
Dopamine inhibits luteinizing hormone synthesis and release in the juvenile European eel: a neuroendocrine lock for the onset of puberty. |
title_short |
Dopamine inhibits luteinizing hormone synthesis and release in the juvenile European eel: a neuroendocrine lock for the onset of puberty. |
title_full |
Dopamine inhibits luteinizing hormone synthesis and release in the juvenile European eel: a neuroendocrine lock for the onset of puberty. |
title_fullStr |
Dopamine inhibits luteinizing hormone synthesis and release in the juvenile European eel: a neuroendocrine lock for the onset of puberty. |
title_full_unstemmed |
Dopamine inhibits luteinizing hormone synthesis and release in the juvenile European eel: a neuroendocrine lock for the onset of puberty. |
title_sort |
dopamine inhibits luteinizing hormone synthesis and release in the juvenile european eel: a neuroendocrine lock for the onset of puberty. |
publisher |
HAL CCSD |
publishDate |
2004 |
url |
https://hal.science/hal-00121615 https://doi.org/10.1095/biolreprod.104.030627 |
genre |
Anguilla anguilla |
genre_facet |
Anguilla anguilla |
op_source |
ISSN: 0006-3363 EISSN: 1529-7268 Biology of Reproduction https://hal.science/hal-00121615 Biology of Reproduction, 2004, 71 (5), pp.1491-500. ⟨10.1095/biolreprod.104.030627⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1095/biolreprod.104.030627 info:eu-repo/semantics/altIdentifier/pmid/15229141 hal-00121615 https://hal.science/hal-00121615 doi:10.1095/biolreprod.104.030627 PUBMED: 15229141 |
op_doi |
https://doi.org/10.1095/biolreprod.104.030627 |
container_title |
Biology of Reproduction |
container_volume |
71 |
container_issue |
5 |
container_start_page |
1491 |
op_container_end_page |
1500 |
_version_ |
1768383447343038464 |