A-to-I editing of COG3 mRNA in bowhead muscle, kidney, liver, optical nerve and retina.

• Main Authors: Knud Larsen (35577), Mads Peter Heide-Jørgensen (7869812)
• Format: Other Non-Article Part of Journal/Newspaper
• Language: unknown
• Published: 2021
• Subjects: Biochemistry; Microbiology; Genetics; Molecular Biology; Evolutionary Biology; Ecology; Inorganic Chemistry; Mental Health; Infectious Diseases; Virology; Computational Biology; two shark species; proteomic sequence variation; recoding &# 8217; specific adenosine deaminase; neil1 242 codon; adar2 &# 8211; novel editing site; novel editing sites; pig </ p; bowhead neil1 mrnas; recoding sites; &# 8216; editing site; two adenosines; position 242; sites results; selected mrnas; regulatory sequence; eef1a mrnas; human neil1; editing mediated; editing events; differential editing; rna sequence; various tissues; transcriptional process; synonymous substitutions; present studies; porcine homologues; nucleotide changes; nearly 99; five adenosines; common type; coding sequences; bowhead whales; bowhead whale
• Online Access: https://doi.org/10.1371/journal.pone.0260081.s001

The adenosine (*) in the ATT codon encoding I635 is subject to A-to-I editing in COG3 mRNA from all tissues analyzed (ATT = Ile to GTT = Val). In addition, the adenosine in the third position in the GAA (634) codon is only edited in liver (+). The unedited GAA codon encodes a Glu residue, as does the edited GAG codon. In addition, we also found editing in codon 621 (GA A ) marked by **. This editing is not recoding. R = A/G. (DOCX)