Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness
Genome-wide association studies provide good opportunities for studying the genetic basis of adaptive traits in wild populations. Yet, previous studies often failed to identify major effect genes. In this study, we used high-density single nucleotide polymorphism and individual fitness data from a w...
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Other Non-Article Part of Journal/Newspaper |
Language: | unknown |
Published: |
2021
|
Subjects: | |
Online Access: | https://doi.org/10.6084/m9.figshare.16657088.v1 |
id |
ftsmithonian:oai:figshare.com:article/16657088 |
---|---|
record_format |
openpolar |
spelling |
ftsmithonian:oai:figshare.com:article/16657088 2023-05-15T14:31:07+02:00 Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness Lukas Tietgen (11465753) Ingerid J. Hagen (6205538) Oddmund Kleven (65846) Cecilia Di Bernardi (11465756) Thomas Kvalnes (11465759) Karin Norén (3246510) Malin Hasselgren (11465762) Johan Fredrik Wallén (11465765) Anders Angerbjörn (180269) Arild Landa (4949110) Nina E. Eide (4949113) Øystein Flagstad (10455639) Henrik Jensen (214354) 2021-09-22T08:30:33Z https://doi.org/10.6084/m9.figshare.16657088.v1 unknown https://figshare.com/articles/journal_contribution/Supplementary_material_1-7_9-12_from_Fur_colour_in_the_Arctic_fox_genetic_architecture_and_consequences_for_fitness/16657088 doi:10.6084/m9.figshare.16657088.v1 CC BY 4.0 CC-BY Genetics Evolutionary Biology Ecology adaptive trait endangered species fitness estimation genome-wide association study indirect selection wild population Text Journal contribution 2021 ftsmithonian https://doi.org/10.6084/m9.figshare.16657088.v1 2021-12-20T01:44:48Z Genome-wide association studies provide good opportunities for studying the genetic basis of adaptive traits in wild populations. Yet, previous studies often failed to identify major effect genes. In this study, we used high-density single nucleotide polymorphism and individual fitness data from a wild non-model species. Using a whole-genome approach, we identified the MC1R gene as the sole causal gene underlying Arctic fox Vulpes lagopus fur colour. Further, we showed the adaptive importance of fur colour genotypes through measures of fitness that link ecological and evolutionary processes. We found a tendency for blue foxes that are heterozygous at the fur colour locus to have higher fitness than homozygous white foxes. The effect of genotype on fitness was independent of winter duration but varied with prey availability, with the strongest effect in years of increasing rodent populations. MC1R is located in a genomic region with high gene density, and we discuss the potential for indirect selection through linkage and pleiotropy. Our study shows that whole-genome analyses can be successfully applied to wild species and identify major effect genes underlying adaptive traits. Furthermore, we show how this approach can be used to identify knowledge gaps in our understanding of interactions between ecology and evolution. Other Non-Article Part of Journal/Newspaper Arctic Fox Arctic Vulpes lagopus Unknown Arctic |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
ftsmithonian |
language |
unknown |
topic |
Genetics Evolutionary Biology Ecology adaptive trait endangered species fitness estimation genome-wide association study indirect selection wild population |
spellingShingle |
Genetics Evolutionary Biology Ecology adaptive trait endangered species fitness estimation genome-wide association study indirect selection wild population Lukas Tietgen (11465753) Ingerid J. Hagen (6205538) Oddmund Kleven (65846) Cecilia Di Bernardi (11465756) Thomas Kvalnes (11465759) Karin Norén (3246510) Malin Hasselgren (11465762) Johan Fredrik Wallén (11465765) Anders Angerbjörn (180269) Arild Landa (4949110) Nina E. Eide (4949113) Øystein Flagstad (10455639) Henrik Jensen (214354) Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
topic_facet |
Genetics Evolutionary Biology Ecology adaptive trait endangered species fitness estimation genome-wide association study indirect selection wild population |
description |
Genome-wide association studies provide good opportunities for studying the genetic basis of adaptive traits in wild populations. Yet, previous studies often failed to identify major effect genes. In this study, we used high-density single nucleotide polymorphism and individual fitness data from a wild non-model species. Using a whole-genome approach, we identified the MC1R gene as the sole causal gene underlying Arctic fox Vulpes lagopus fur colour. Further, we showed the adaptive importance of fur colour genotypes through measures of fitness that link ecological and evolutionary processes. We found a tendency for blue foxes that are heterozygous at the fur colour locus to have higher fitness than homozygous white foxes. The effect of genotype on fitness was independent of winter duration but varied with prey availability, with the strongest effect in years of increasing rodent populations. MC1R is located in a genomic region with high gene density, and we discuss the potential for indirect selection through linkage and pleiotropy. Our study shows that whole-genome analyses can be successfully applied to wild species and identify major effect genes underlying adaptive traits. Furthermore, we show how this approach can be used to identify knowledge gaps in our understanding of interactions between ecology and evolution. |
format |
Other Non-Article Part of Journal/Newspaper |
author |
Lukas Tietgen (11465753) Ingerid J. Hagen (6205538) Oddmund Kleven (65846) Cecilia Di Bernardi (11465756) Thomas Kvalnes (11465759) Karin Norén (3246510) Malin Hasselgren (11465762) Johan Fredrik Wallén (11465765) Anders Angerbjörn (180269) Arild Landa (4949110) Nina E. Eide (4949113) Øystein Flagstad (10455639) Henrik Jensen (214354) |
author_facet |
Lukas Tietgen (11465753) Ingerid J. Hagen (6205538) Oddmund Kleven (65846) Cecilia Di Bernardi (11465756) Thomas Kvalnes (11465759) Karin Norén (3246510) Malin Hasselgren (11465762) Johan Fredrik Wallén (11465765) Anders Angerbjörn (180269) Arild Landa (4949110) Nina E. Eide (4949113) Øystein Flagstad (10455639) Henrik Jensen (214354) |
author_sort |
Lukas Tietgen (11465753) |
title |
Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_short |
Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_full |
Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_fullStr |
Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_full_unstemmed |
Supplementary material 1-7; 9-12 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_sort |
supplementary material 1-7; 9-12 from fur colour in the arctic fox: genetic architecture and consequences for fitness |
publishDate |
2021 |
url |
https://doi.org/10.6084/m9.figshare.16657088.v1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Fox Arctic Vulpes lagopus |
genre_facet |
Arctic Fox Arctic Vulpes lagopus |
op_relation |
https://figshare.com/articles/journal_contribution/Supplementary_material_1-7_9-12_from_Fur_colour_in_the_Arctic_fox_genetic_architecture_and_consequences_for_fitness/16657088 doi:10.6084/m9.figshare.16657088.v1 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.16657088.v1 |
_version_ |
1766304838856998912 |