Nudged Elastic Band Method for Molecular Reactions Using Energy-Weighted Springs Combined with Eigenvector Following

• Main Authors: Vilhjálmur Ásgeirsson (7854128), Benedikt Orri Birgisson (11150612), Ragnar Bjornsson (1303791), Ute Becker (736439), Frank Neese (736441), Christoph Riplinger (1609360), Hannes Jónsson (1847959)
• Format: Dataset
• Language: unknown
• Published: 2021
• Subjects: Biophysics; Biochemistry; Medicine; Sociology; Computational Biology; Space Science; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; Physical Sciences not elsewhere classified; Information Systems not elsewhere classified; calculation; image; force evaluations; Nudged Elastic Band Method; performance; spring constants increase; saddle points; ORCA; energy-weighted CI-NEB method; saddle point search; NEB-TS; saddle point; Saddle Point; Orca
• Online Access: https://doi.org/10.1021/acs.jctc.1c00462.s002

The climbing image nudged elastic band method (CI-NEB) is used to identify reaction coordinates and to find saddle points representing transition states of reactions. It can make efficient use of parallel computing as the calculations of the discretization points, the so-called images, can be carried out simultaneously. In typical implementations, the images are distributed evenly along the path by connecting adjacent images with equally stiff springs. However, for systems with a high degree of flexibility, this can lead to poor resolution near the saddle point. By making the spring constants increase with energy, the resolution near the saddle point is improved. To assess the performance of this energy-weighted CI-NEB method, calculations are carried out for a benchmark set of 121 molecular reactions. The performance of the method is analyzed with respect to the input parameters. Energy-weighted springs are found to greatly improve performance and result in successful location of the saddle points in less than a thousand energy and force evaluations on average (about a hundred per image) using the same set of parameter values for all of the reactions. Even better performance is obtained by stopping the calculation before full convergence and complete the saddle point search using an eigenvector following method starting from the location of the climbing image. This combination of methods, referred to as NEB-TS, turns out to be robust and highly efficient as it reduces the average number of energy and force evaluations down to a third, to 305. An efficient and flexible implementation of these methods has been made available in the ORCA software.