Critical analysis of spirometric patterns in correlation to chest computed tomography among adult Indigenous Australians with chronic airway diseases

Background : There is sparse literature evidence in the spirometric patterns of adult Indigenous Australians with and without chest computed tomography (CT)-proven chronic airway diseases (CADs). Methods : Participants spirometry testing graded as acceptable for quality and had a chest CT scan showi...

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Bibliographic Details
Main Authors: Subash S Heraganahally (11068623), Timothy Howarth (8727231), Lin Mo (9193226), Lisa Sorger (9673883), Helmi Ben Saad (7840790)
Format: Other Non-Article Part of Journal/Newspaper
Language:unknown
Published: 2021
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Online Access:https://doi.org/10.6084/m9.figshare.14903097.v1
Description
Summary:Background : There is sparse literature evidence in the spirometric patterns of adult Indigenous Australians with and without chest computed tomography (CT)-proven chronic airway diseases (CADs). Methods : Participants spirometry testing graded as acceptable for quality and had a chest CT scan showing radiographic evidence of CADs were included for analysis. Results : Of the 1350 spirometric tests performed between 2012 and 2020, a total of 212 patients with a mean age of 53 years and 54% females were eligible to be included. One-third (30%) had normal chest CT (without CADs), 35% had predominant COPD, 19% bronchiectasis and 16% combined COPD and bronchiectasis. Percentage predicted values for forced vital capacity (FVC) and forced expiratory volume in one second (FEV 1 ) both pre- and post- bronchodilator were significantly reduced for all participants – FVC: CT-normal 64%, 65%; COPD 58%, 62%; bronchiectasis 54%, 54%; combined COPD and bronchiectasis 50%, 53%. FEV 1 : CT-normal 62%, 65%; COPD 46%, 49%; bronchiectasis 48%,51%; combined COPD and bronchiectasis 36%,40%. FEV 1 /FVC was only reduced for CT abnormality patients – CT-normal 96%,98%; COPD 77%,77%; bronchiectasis 87%,89%; combined COPD and bronchiectasis 71%,72%. Conclusions : Restrictive spirometric pattern is common and an obstructive pattern with COPD, in isolation or when COPD coexists with bronchiectasis.