Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1
Two new polyketides, palitantins B and C ( 1 and 2 ), along with one known related compound (+)-palitantin ( 3 ) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compou...
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ftsmithonian:oai:figshare.com:article/14479144 2023-05-15T13:50:15+02:00 Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1 Hao-Bing Yu (1596820) Bo Hu (126105) Jie Kong (702788) Yun-Hai Li (4500361) Ying He (125930) Xiao-Ling Lu (545017) Bing-Hua Jiao (545018) Xiao-Yu Liu (423505) 2021-04-24T05:40:02Z https://doi.org/10.6084/m9.figshare.14479144.v1 unknown https://figshare.com/articles/journal_contribution/Palitantin_derivatives_from_the_Antarctic_fungus_i_Geomyces_i_sp_3-1/14479144 doi:10.6084/m9.figshare.14479144.v1 CC BY 4.0 CC-BY Biochemistry Microbiology Pharmacology Ecology Inorganic Chemistry Plant Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Geomyces sp polyketide PTP1B inhibitory activity Text Journal contribution 2021 ftsmithonian https://doi.org/10.6084/m9.figshare.14479144.v1 2021-05-05T17:34:34Z Two new polyketides, palitantins B and C ( 1 and 2 ), along with one known related compound (+)-palitantin ( 3 ) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compound 3 showed potent PTP1B inhibitory activity with an IC 50 value of 7.9 μ M (ursolic acid as positive control, IC 50 = 8.3 μ M). Other Non-Article Part of Journal/Newspaper Antarc* Antarctic Unknown Antarctic The Antarctic |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
ftsmithonian |
language |
unknown |
topic |
Biochemistry Microbiology Pharmacology Ecology Inorganic Chemistry Plant Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Geomyces sp polyketide PTP1B inhibitory activity |
spellingShingle |
Biochemistry Microbiology Pharmacology Ecology Inorganic Chemistry Plant Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Geomyces sp polyketide PTP1B inhibitory activity Hao-Bing Yu (1596820) Bo Hu (126105) Jie Kong (702788) Yun-Hai Li (4500361) Ying He (125930) Xiao-Ling Lu (545017) Bing-Hua Jiao (545018) Xiao-Yu Liu (423505) Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1 |
topic_facet |
Biochemistry Microbiology Pharmacology Ecology Inorganic Chemistry Plant Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Geomyces sp polyketide PTP1B inhibitory activity |
description |
Two new polyketides, palitantins B and C ( 1 and 2 ), along with one known related compound (+)-palitantin ( 3 ) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compound 3 showed potent PTP1B inhibitory activity with an IC 50 value of 7.9 μ M (ursolic acid as positive control, IC 50 = 8.3 μ M). |
format |
Other Non-Article Part of Journal/Newspaper |
author |
Hao-Bing Yu (1596820) Bo Hu (126105) Jie Kong (702788) Yun-Hai Li (4500361) Ying He (125930) Xiao-Ling Lu (545017) Bing-Hua Jiao (545018) Xiao-Yu Liu (423505) |
author_facet |
Hao-Bing Yu (1596820) Bo Hu (126105) Jie Kong (702788) Yun-Hai Li (4500361) Ying He (125930) Xiao-Ling Lu (545017) Bing-Hua Jiao (545018) Xiao-Yu Liu (423505) |
author_sort |
Hao-Bing Yu (1596820) |
title |
Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1 |
title_short |
Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1 |
title_full |
Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1 |
title_fullStr |
Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1 |
title_full_unstemmed |
Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1 |
title_sort |
palitantin derivatives from the antarctic fungus geomyces sp. 3-1 |
publishDate |
2021 |
url |
https://doi.org/10.6084/m9.figshare.14479144.v1 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
https://figshare.com/articles/journal_contribution/Palitantin_derivatives_from_the_Antarctic_fungus_i_Geomyces_i_sp_3-1/14479144 doi:10.6084/m9.figshare.14479144.v1 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.14479144.v1 |
_version_ |
1766253281963671552 |