Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1

• Main Authors: Hao-Bing Yu (1596820), Bo Hu (126105), Jie Kong (702788), Yun-Hai Li (4500361), Ying He (125930), Xiao-Ling Lu (545017), Bing-Hua Jiao (545018), Xiao-Yu Liu (423505)
• Format: Other Non-Article Part of Journal/Newspaper
• Language: unknown
• Published: 2021
• Subjects: Biochemistry; Microbiology; Pharmacology; Ecology; Inorganic Chemistry; Plant Biology; Environmental Sciences not elsewhere classified; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; Geomyces sp; polyketide; PTP1B inhibitory activity; Antarctic; The Antarctic; Antarc*
• Online Access: https://doi.org/10.6084/m9.figshare.14479144.v1

Two new polyketides, palitantins B and C ( 1 and 2 ), along with one known related compound (+)-palitantin ( 3 ) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compound 3 showed potent PTP1B inhibitory activity with an IC 50 value of 7.9 μ M (ursolic acid as positive control, IC 50 = 8.3 μ M).