Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1

Two new polyketides, palitantins B and C ( 1 and 2 ), along with one known related compound (+)-palitantin ( 3 ) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compou...

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Bibliographic Details
Main Authors: Hao-Bing Yu (1596820), Bo Hu (126105), Jie Kong (702788), Yun-Hai Li (4500361), Ying He (125930), Xiao-Ling Lu (545017), Bing-Hua Jiao (545018), Xiao-Yu Liu (423505)
Format: Other Non-Article Part of Journal/Newspaper
Language:unknown
Published: 2021
Subjects:
Biochemistry
Microbiology
Pharmacology
Ecology
Inorganic Chemistry
Plant Biology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Geomyces sp
polyketide
PTP1B inhibitory activity
Antarctic
The Antarctic
Antarc*
Online Access:https://doi.org/10.6084/m9.figshare.14479144.v1
Description
Summary:Two new polyketides, palitantins B and C ( 1 and 2 ), along with one known related compound (+)-palitantin ( 3 ) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compound 3 showed potent PTP1B inhibitory activity with an IC 50 value of 7.9 μ M (ursolic acid as positive control, IC 50 = 8.3 μ M).

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