Oxylipin Responses to Fasting and Insulin Infusion in a Large Mammalian Model of Fasting-Induced Insulin Resistance, the Northern Elephant Seal
This study complements the previous study by examining the effects of fasting duration and insulin infusion on circulating levels of oxylipins, bioactive metabolites derived from the oxygenation of polyunsaturated fatty acids. Northern elephant seal pups were studied at two post-weaning periods (n =...
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ftsmithonian:oai:figshare.com:article/13577909 2023-05-15T16:05:09+02:00 Oxylipin Responses to Fasting and Insulin Infusion in a Large Mammalian Model of Fasting-Induced Insulin Resistance, the Northern Elephant Seal Michael La Frano (9987986) Rudy Ortiz (7456632) John W. Newman (9988001) 2021-08-03T18:04:43Z https://doi.org/10.6084/m9.figshare.13577909.v1 unknown https://figshare.com/articles/dataset/Oxylipin_Responses_to_Fasting_and_Insulin_Infusion_in_a_Large_Mammalian_Model_of_Fasting-Induced_Insulin_Resistance_the_Northern_Elephant_Seal/13577909 doi:10.6084/m9.figshare.13577909.v1 CC BY 4.0 CC-BY Animal Physiology - Cell Comparative Physiology Animal Developmental and Reproductive Biology elephant seals insulin resistance results oxylipin responses Dataset 2021 ftsmithonian https://doi.org/10.6084/m9.figshare.13577909.v1 2021-12-20T05:07:12Z This study complements the previous study by examining the effects of fasting duration and insulin infusion on circulating levels of oxylipins, bioactive metabolites derived from the oxygenation of polyunsaturated fatty acids. Northern elephant seal pups were studied at two post-weaning periods (n = 5/period): early fasting (1–2 weeks post-weaning; 127 ± 1 kg) and late fasting (6–7 weeks post-weaning; 93 ± 4 kg). Different cohorts of pups were weighed, sedated, and infused with 65 mU/kg of insulin. Plasma was collected prior to infusion (T0), and at 10, 30, 60, and 120 min post-infusion. A profile of ~80 oxylipins were analyzed by UPLC-ESI-MS/MS. Dataset Elephant Seal Elephant Seals Unknown |
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ftsmithonian |
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Animal Physiology - Cell Comparative Physiology Animal Developmental and Reproductive Biology elephant seals insulin resistance results oxylipin responses |
spellingShingle |
Animal Physiology - Cell Comparative Physiology Animal Developmental and Reproductive Biology elephant seals insulin resistance results oxylipin responses Michael La Frano (9987986) Rudy Ortiz (7456632) John W. Newman (9988001) Oxylipin Responses to Fasting and Insulin Infusion in a Large Mammalian Model of Fasting-Induced Insulin Resistance, the Northern Elephant Seal |
topic_facet |
Animal Physiology - Cell Comparative Physiology Animal Developmental and Reproductive Biology elephant seals insulin resistance results oxylipin responses |
description |
This study complements the previous study by examining the effects of fasting duration and insulin infusion on circulating levels of oxylipins, bioactive metabolites derived from the oxygenation of polyunsaturated fatty acids. Northern elephant seal pups were studied at two post-weaning periods (n = 5/period): early fasting (1–2 weeks post-weaning; 127 ± 1 kg) and late fasting (6–7 weeks post-weaning; 93 ± 4 kg). Different cohorts of pups were weighed, sedated, and infused with 65 mU/kg of insulin. Plasma was collected prior to infusion (T0), and at 10, 30, 60, and 120 min post-infusion. A profile of ~80 oxylipins were analyzed by UPLC-ESI-MS/MS. |
format |
Dataset |
author |
Michael La Frano (9987986) Rudy Ortiz (7456632) John W. Newman (9988001) |
author_facet |
Michael La Frano (9987986) Rudy Ortiz (7456632) John W. Newman (9988001) |
author_sort |
Michael La Frano (9987986) |
title |
Oxylipin Responses to Fasting and Insulin Infusion in a Large Mammalian Model of Fasting-Induced Insulin Resistance, the Northern Elephant Seal |
title_short |
Oxylipin Responses to Fasting and Insulin Infusion in a Large Mammalian Model of Fasting-Induced Insulin Resistance, the Northern Elephant Seal |
title_full |
Oxylipin Responses to Fasting and Insulin Infusion in a Large Mammalian Model of Fasting-Induced Insulin Resistance, the Northern Elephant Seal |
title_fullStr |
Oxylipin Responses to Fasting and Insulin Infusion in a Large Mammalian Model of Fasting-Induced Insulin Resistance, the Northern Elephant Seal |
title_full_unstemmed |
Oxylipin Responses to Fasting and Insulin Infusion in a Large Mammalian Model of Fasting-Induced Insulin Resistance, the Northern Elephant Seal |
title_sort |
oxylipin responses to fasting and insulin infusion in a large mammalian model of fasting-induced insulin resistance, the northern elephant seal |
publishDate |
2021 |
url |
https://doi.org/10.6084/m9.figshare.13577909.v1 |
genre |
Elephant Seal Elephant Seals |
genre_facet |
Elephant Seal Elephant Seals |
op_relation |
https://figshare.com/articles/dataset/Oxylipin_Responses_to_Fasting_and_Insulin_Infusion_in_a_Large_Mammalian_Model_of_Fasting-Induced_Insulin_Resistance_the_Northern_Elephant_Seal/13577909 doi:10.6084/m9.figshare.13577909.v1 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.13577909.v1 |
_version_ |
1766400949688991744 |