Beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout
Salmonid fish include some of the most valued cultured fish species worldwide. Unlike most other fish, the hearts of salmonids, including Atlantic salmon and rainbow trout, have a well-developed coronary circulation. Consequently, their hearts' reliance on oxygenation through coronary arteries...
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AMER PHYSIOLOGICAL SOC
2024
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ftslunivuppsala:oai:pub.epsilon.slu.se:35048 2024-09-30T14:32:32+00:00 Beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout Zena, Lucas Gräns, Albin 2024 application/pdf https://pub.epsilon.slu.se/35048/ https://pub.epsilon.slu.se/35048/1/zena-l-a-et-al-20240913.pdf en eng eng AMER PHYSIOLOGICAL SOC https://pub.epsilon.slu.se/35048/1/zena-l-a-et-al-20240913.pdf Zena, Lucas and Gräns, Albin (2024). Beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout. AJP - Regulatory, Integrative and Comparative Physiology. 326 :6 , R484-R498 [Research article] Medical Bioscience Research article NonPeerReviewed info:eu-repo/semantics/article 2024 ftslunivuppsala 2024-09-17T23:59:27Z Salmonid fish include some of the most valued cultured fish species worldwide. Unlike most other fish, the hearts of salmonids, including Atlantic salmon and rainbow trout, have a well-developed coronary circulation. Consequently, their hearts' reliance on oxygenation through coronary arteries leaves them prone to coronary lesions, believed to precipitate myocardial ischemia. Here, we mimicked such coronary lesions by subjecting groups of juvenile rainbow trout to coronary ligation, assessing histomorphological myocardial changes associated with ischemia and scarring in the context of cardiac arrhythmias using electrocardiography (ECG). Notable ECG changes resembling myocardial ischemia-like ECG in humans, such as atrioventricular blocks and abnormal ventricular depolarization (prolonged and fragmented QRS complex), as well as repolarization (long QT interval) patterns, were observed during the acute phase of myocardial ischemia. A remarkable 100% survival rate was observed among juvenile trout subjected to coronary ligation after 24 wk. Recovery from coronary ligation occurred through adaptive ventricular remodeling, coupled with a fast cardiac revascularization response. These findings carry significant implications for understanding the mechanisms governing cardiac health in salmonid fish, a family particularly susceptible to cardiac diseases. Furthermore, our results provide valuable insights into comparative studies on the evolution, pathophysiology, and ontogeny of vertebrate cardiac repair and restoration. NEW & NOTEWORTHY Juvenile rainbow trout exhibit a remarkable capacity to recover from cardiac injury caused by myocardial ischemia. Recovery from cardiac damage occurs through adaptive ventricular remodeling, coupled with a rapid cardiac revascularization response. These findings carry significant implications for understanding the mechanisms governing cardiac health within salmonid fishes, which are particularly susceptible to cardiac diseases. Article in Journal/Newspaper Atlantic salmon Swedish University of Agricultural Sciences (SLU): Epsilon Open Archive |
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Swedish University of Agricultural Sciences (SLU): Epsilon Open Archive |
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English |
topic |
Medical Bioscience |
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Medical Bioscience Zena, Lucas Gräns, Albin Beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout |
topic_facet |
Medical Bioscience |
description |
Salmonid fish include some of the most valued cultured fish species worldwide. Unlike most other fish, the hearts of salmonids, including Atlantic salmon and rainbow trout, have a well-developed coronary circulation. Consequently, their hearts' reliance on oxygenation through coronary arteries leaves them prone to coronary lesions, believed to precipitate myocardial ischemia. Here, we mimicked such coronary lesions by subjecting groups of juvenile rainbow trout to coronary ligation, assessing histomorphological myocardial changes associated with ischemia and scarring in the context of cardiac arrhythmias using electrocardiography (ECG). Notable ECG changes resembling myocardial ischemia-like ECG in humans, such as atrioventricular blocks and abnormal ventricular depolarization (prolonged and fragmented QRS complex), as well as repolarization (long QT interval) patterns, were observed during the acute phase of myocardial ischemia. A remarkable 100% survival rate was observed among juvenile trout subjected to coronary ligation after 24 wk. Recovery from coronary ligation occurred through adaptive ventricular remodeling, coupled with a fast cardiac revascularization response. These findings carry significant implications for understanding the mechanisms governing cardiac health in salmonid fish, a family particularly susceptible to cardiac diseases. Furthermore, our results provide valuable insights into comparative studies on the evolution, pathophysiology, and ontogeny of vertebrate cardiac repair and restoration. NEW & NOTEWORTHY Juvenile rainbow trout exhibit a remarkable capacity to recover from cardiac injury caused by myocardial ischemia. Recovery from cardiac damage occurs through adaptive ventricular remodeling, coupled with a rapid cardiac revascularization response. These findings carry significant implications for understanding the mechanisms governing cardiac health within salmonid fishes, which are particularly susceptible to cardiac diseases. |
format |
Article in Journal/Newspaper |
author |
Zena, Lucas Gräns, Albin |
author_facet |
Zena, Lucas Gräns, Albin |
author_sort |
Zena, Lucas |
title |
Beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout |
title_short |
Beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout |
title_full |
Beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout |
title_fullStr |
Beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout |
title_full_unstemmed |
Beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout |
title_sort |
beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout |
publisher |
AMER PHYSIOLOGICAL SOC |
publishDate |
2024 |
url |
https://pub.epsilon.slu.se/35048/ https://pub.epsilon.slu.se/35048/1/zena-l-a-et-al-20240913.pdf |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
https://pub.epsilon.slu.se/35048/1/zena-l-a-et-al-20240913.pdf Zena, Lucas and Gräns, Albin (2024). Beating the heart failure odds: long-term survival after myocardial ischemia in juvenile rainbow trout. AJP - Regulatory, Integrative and Comparative Physiology. 326 :6 , R484-R498 [Research article] |
_version_ |
1811636684525142016 |