Potential natural immunization against atherosclerosis in hibernating bears
Brown bears (Ursus arctos) hibernate for 5-6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associat...
Main Authors: | , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2021
|
Subjects: | |
Online Access: | https://pub.epsilon.slu.se/25045/ https://pub.epsilon.slu.se/25045/1/samal_k_s_et_al_210826.pdf |
id |
ftslunivuppsala:oai:pub.epsilon.slu.se:25045 |
---|---|
record_format |
openpolar |
spelling |
ftslunivuppsala:oai:pub.epsilon.slu.se:25045 2023-05-15T18:42:10+02:00 Potential natural immunization against atherosclerosis in hibernating bears Samal, Shailesh Kumar Frobert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegard, Johan 2021 application/pdf https://pub.epsilon.slu.se/25045/ https://pub.epsilon.slu.se/25045/1/samal_k_s_et_al_210826.pdf en eng eng https://pub.epsilon.slu.se/25045/1/samal_k_s_et_al_210826.pdf Samal, Shailesh Kumar and Frobert, Ole and Kindberg, Jonas and Stenvinkel, Peter and Frostegard, Johan (2021). Potential natural immunization against atherosclerosis in hibernating bears. Scientific Reports. 11 , 12120 [Research article] Clinical Science Research article NonPeerReviewed 2021 ftslunivuppsala 2022-01-09T19:16:34Z Brown bears (Ursus arctos) hibernate for 5-6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated with less atherosclerosis, CVD and mortality in uremia in humans and have anti-inflammatory and other potentially protective properties. PC but not MDA is exposed on different types of microorganisms. We determine anti-PC and anti-MDA in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by enzyme linked immunosorbent assay (ELISA). When determined as arbitrary units (median set at 100 for summer samples), significantly raised levels were observed in winter for anti-PC subclasses and isotypes, and for IgA anti-PC the difference was striking; 100 IQR (85.9-107.9) vs 782.3, IQR (422.8-1586.0; p<0.001). In contrast, subclasses and isotypes of anti-MDA were significantly lower in winter except IgA anti-MDA, which was not detectable. Anti-PCs are significantly raised during hibernation in brown bears; especially IgA anti-PC was strikingly high. In contrast, anti-MDA titers was decreased during hibernation. Our observation may represent natural immunization with microorganisms during a vulnerable period and could have therapeutic implications for prevention of atherosclerosis. Article in Journal/Newspaper Ursus arctos Swedish University of Agricultural Sciences (SLU): Epsilon Open Archive |
institution |
Open Polar |
collection |
Swedish University of Agricultural Sciences (SLU): Epsilon Open Archive |
op_collection_id |
ftslunivuppsala |
language |
English |
topic |
Clinical Science |
spellingShingle |
Clinical Science Samal, Shailesh Kumar Frobert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegard, Johan Potential natural immunization against atherosclerosis in hibernating bears |
topic_facet |
Clinical Science |
description |
Brown bears (Ursus arctos) hibernate for 5-6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated with less atherosclerosis, CVD and mortality in uremia in humans and have anti-inflammatory and other potentially protective properties. PC but not MDA is exposed on different types of microorganisms. We determine anti-PC and anti-MDA in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by enzyme linked immunosorbent assay (ELISA). When determined as arbitrary units (median set at 100 for summer samples), significantly raised levels were observed in winter for anti-PC subclasses and isotypes, and for IgA anti-PC the difference was striking; 100 IQR (85.9-107.9) vs 782.3, IQR (422.8-1586.0; p<0.001). In contrast, subclasses and isotypes of anti-MDA were significantly lower in winter except IgA anti-MDA, which was not detectable. Anti-PCs are significantly raised during hibernation in brown bears; especially IgA anti-PC was strikingly high. In contrast, anti-MDA titers was decreased during hibernation. Our observation may represent natural immunization with microorganisms during a vulnerable period and could have therapeutic implications for prevention of atherosclerosis. |
format |
Article in Journal/Newspaper |
author |
Samal, Shailesh Kumar Frobert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegard, Johan |
author_facet |
Samal, Shailesh Kumar Frobert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegard, Johan |
author_sort |
Samal, Shailesh Kumar |
title |
Potential natural immunization against atherosclerosis in hibernating bears |
title_short |
Potential natural immunization against atherosclerosis in hibernating bears |
title_full |
Potential natural immunization against atherosclerosis in hibernating bears |
title_fullStr |
Potential natural immunization against atherosclerosis in hibernating bears |
title_full_unstemmed |
Potential natural immunization against atherosclerosis in hibernating bears |
title_sort |
potential natural immunization against atherosclerosis in hibernating bears |
publishDate |
2021 |
url |
https://pub.epsilon.slu.se/25045/ https://pub.epsilon.slu.se/25045/1/samal_k_s_et_al_210826.pdf |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_relation |
https://pub.epsilon.slu.se/25045/1/samal_k_s_et_al_210826.pdf Samal, Shailesh Kumar and Frobert, Ole and Kindberg, Jonas and Stenvinkel, Peter and Frostegard, Johan (2021). Potential natural immunization against atherosclerosis in hibernating bears. Scientific Reports. 11 , 12120 [Research article] |
_version_ |
1766231780330831872 |