Risk Factors for hypospadias in Northwest Russia : A Murmansk County Birth Registry Study
BACKGROUND: Hypospadias is the most common congenital anomaly of the penis, but its causes are mainly unknown. Of the risk factors identified, the most plausible are hormonal and genetic. The aim of this study was to identify risk factors for hypospadias in Northwest Russia based on registry data. M...
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Högskolan i Skövde, Institutionen för hälsa och lärande
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16752 https://doi.org/10.1371/journal.pone.0214213 |
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ftskoevdehoeg:oai:DiVA.org:his-16752 2023-05-15T17:46:04+02:00 Risk Factors for hypospadias in Northwest Russia : A Murmansk County Birth Registry Study Kovalenko, Anton A. Brenn, Tormod Odland, Jon Øyvind Nieboer, Evert Krettek, Alexandra Anda, Erik Eik 2019 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16752 https://doi.org/10.1371/journal.pone.0214213 eng eng Högskolan i Skövde, Institutionen för hälsa och lärande Högskolan i Skövde, Forskningsspecialiseringen Hälsa och Lärande Department of Community Medicine, UiT -The Arctic University of Norway, Tromsø, Norway / International School of Public Health, Northern State Medical University, Arkhangelsk, Russia Department of Community Medicine, UiT -The Arctic University of Norway, Tromsø, Norway Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada Department of Community Medicine, UiT -The Arctic University of Norway, Tromsø, Norway / Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Public Library of Science PLOS ONE, 2019, 14:4, http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16752 doi:10.1371/journal.pone.0214213 PMID 30946760 ISI:000463314500020 Scopus 2-s2.0-85063936379 info:eu-repo/semantics/openAccess Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Article in journal info:eu-repo/semantics/article text 2019 ftskoevdehoeg https://doi.org/10.1371/journal.pone.0214213 2022-10-25T20:52:24Z BACKGROUND: Hypospadias is the most common congenital anomaly of the penis, but its causes are mainly unknown. Of the risk factors identified, the most plausible are hormonal and genetic. The aim of this study was to identify risk factors for hypospadias in Northwest Russia based on registry data. METHODS: The study population included male infants registered in the Murmansk County Birth Registry between 1 January 2006 and 31 December 2011 (n = 25 475). These infants were followed-up for 2 years using the Murmansk Regional Congenital Defects Registry to identify cases of hypospadias not diagnosed at birth. We used logistic regression analysis to examine the contributions of hypospadias risk factors. RESULTS: Out of 25 475 male infants born during the study period, 148 had isolated hypospadias. The overall prevalence rate was 54.2 (95% CI 53.6-54.8) per 10 000 male infants. Those born to mothers with preeclampsia (OR = 1.65; 95% CI 1.03-2.66) or infant birthweight < 2500 g (OR = 2.06; 95% CI 1.18-3.60) exhibited increased risk for hypospadias. Maternal age, smoking during pregnancy, folic acid intake during pregnancy or hepatitis B surface antigen positivity did not associate with increased risk of hypospadias. CONCLUSIONS: Combining data from a birth registry with those from a congenital defects registry provided optimal information about the prevalence of hypospadias and its association with low infant birthweight and preeclampsia. These factors have in common changes in hormone levels during pregnancy, which in turn may have contributed to hypospadias development. Article in Journal/Newspaper Northwest Russia University of Skövde: Publications (DiVA) Murmansk PLOS ONE 14 4 e0214213 |
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Open Polar |
collection |
University of Skövde: Publications (DiVA) |
op_collection_id |
ftskoevdehoeg |
language |
English |
topic |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
spellingShingle |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Kovalenko, Anton A. Brenn, Tormod Odland, Jon Øyvind Nieboer, Evert Krettek, Alexandra Anda, Erik Eik Risk Factors for hypospadias in Northwest Russia : A Murmansk County Birth Registry Study |
topic_facet |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
description |
BACKGROUND: Hypospadias is the most common congenital anomaly of the penis, but its causes are mainly unknown. Of the risk factors identified, the most plausible are hormonal and genetic. The aim of this study was to identify risk factors for hypospadias in Northwest Russia based on registry data. METHODS: The study population included male infants registered in the Murmansk County Birth Registry between 1 January 2006 and 31 December 2011 (n = 25 475). These infants were followed-up for 2 years using the Murmansk Regional Congenital Defects Registry to identify cases of hypospadias not diagnosed at birth. We used logistic regression analysis to examine the contributions of hypospadias risk factors. RESULTS: Out of 25 475 male infants born during the study period, 148 had isolated hypospadias. The overall prevalence rate was 54.2 (95% CI 53.6-54.8) per 10 000 male infants. Those born to mothers with preeclampsia (OR = 1.65; 95% CI 1.03-2.66) or infant birthweight < 2500 g (OR = 2.06; 95% CI 1.18-3.60) exhibited increased risk for hypospadias. Maternal age, smoking during pregnancy, folic acid intake during pregnancy or hepatitis B surface antigen positivity did not associate with increased risk of hypospadias. CONCLUSIONS: Combining data from a birth registry with those from a congenital defects registry provided optimal information about the prevalence of hypospadias and its association with low infant birthweight and preeclampsia. These factors have in common changes in hormone levels during pregnancy, which in turn may have contributed to hypospadias development. |
format |
Article in Journal/Newspaper |
author |
Kovalenko, Anton A. Brenn, Tormod Odland, Jon Øyvind Nieboer, Evert Krettek, Alexandra Anda, Erik Eik |
author_facet |
Kovalenko, Anton A. Brenn, Tormod Odland, Jon Øyvind Nieboer, Evert Krettek, Alexandra Anda, Erik Eik |
author_sort |
Kovalenko, Anton A. |
title |
Risk Factors for hypospadias in Northwest Russia : A Murmansk County Birth Registry Study |
title_short |
Risk Factors for hypospadias in Northwest Russia : A Murmansk County Birth Registry Study |
title_full |
Risk Factors for hypospadias in Northwest Russia : A Murmansk County Birth Registry Study |
title_fullStr |
Risk Factors for hypospadias in Northwest Russia : A Murmansk County Birth Registry Study |
title_full_unstemmed |
Risk Factors for hypospadias in Northwest Russia : A Murmansk County Birth Registry Study |
title_sort |
risk factors for hypospadias in northwest russia : a murmansk county birth registry study |
publisher |
Högskolan i Skövde, Institutionen för hälsa och lärande |
publishDate |
2019 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16752 https://doi.org/10.1371/journal.pone.0214213 |
geographic |
Murmansk |
geographic_facet |
Murmansk |
genre |
Northwest Russia |
genre_facet |
Northwest Russia |
op_relation |
PLOS ONE, 2019, 14:4, http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16752 doi:10.1371/journal.pone.0214213 PMID 30946760 ISI:000463314500020 Scopus 2-s2.0-85063936379 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0214213 |
container_title |
PLOS ONE |
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14 |
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4 |
container_start_page |
e0214213 |
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