Association of incident gabapentin use: with long-term use of opioids, benzodiazepines and Z-drugs
Gabapentin was originally approved for treatment of seizures in patients with epilepsy and has also been used for neuropathic and inflammatory pain. In addition, off-label use has increased for various disorders, including mental disorders, such as anxiety disorders and bipolar disorders as well as...
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ftskemman:oai:skemman.is:1946/44618 2023-06-18T03:41:26+02:00 Association of incident gabapentin use: with long-term use of opioids, benzodiazepines and Z-drugs Bjarni Páll Linnet Runólfsson 1996- Háskóli Íslands 2023-05 application/pdf http://hdl.handle.net/1946/44618 en eng http://hdl.handle.net/1946/44618 Heilbrigðisvísindi Thesis Master's 2023 ftskemman 2023-06-07T22:53:22Z Gabapentin was originally approved for treatment of seizures in patients with epilepsy and has also been used for neuropathic and inflammatory pain. In addition, off-label use has increased for various disorders, including mental disorders, such as anxiety disorders and bipolar disorders as well as chronic back pain. Gabapentin prescriptions have increased markedly in recent years in the United States and in the United Kingdom. Recent studies suggest that gabapentin is misused when taken with other drugs, such as opioids, benzodiazepines (BZD) and Z-drugs. Although gabapentin is considered safe when used alone, concomitant use with the aforementioned drugs is dangerous and increases the risk of overdose. The aim of this research was to investigate the association between long-term use of opioids, BZD and Z-drugs and incident gabapentin use. The study included persons who contacted services of the Primary Health Care of the Capital Area in Iceland from January 2009 to December 2012. Information medical diagnoses (ICD-10 codes) were retrieved from the medical records database of the Primary Health Care of the Capital Area. Data on prescriptions for opioids, BZD and Z-drugs were obtained from the Prescription Medicines Register at the Directorate of Health. The subjects in the study were divided into four groups with respect to long-term (continous for three-years) use of defined daily dose (DDD) of opioids, BZD and Z-drugs and the incidence rate ratio (IRR) of gabapentin was assessed using Cox regression. The effect of certain chronic conditions and long-term use of SSRI drugs was also explored. Finally, the magnitude and duration of future gabapentin use was examined. The results showed that long-term use of opioids, BZD or Z-drugs was associated with increased risk of future gabapentin use. Individuals using opioids and equal or over 30 DDDs of BZD or Z-drugs were most likely to initiate gabapentin therapy (IRR 7.42; 95% CI 6.69-8.22). These individuals also had the longest average duration of future gabapentin ... Master Thesis Iceland Skemman (Iceland) |
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Heilbrigðisvísindi Bjarni Páll Linnet Runólfsson 1996- Association of incident gabapentin use: with long-term use of opioids, benzodiazepines and Z-drugs |
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Heilbrigðisvísindi |
description |
Gabapentin was originally approved for treatment of seizures in patients with epilepsy and has also been used for neuropathic and inflammatory pain. In addition, off-label use has increased for various disorders, including mental disorders, such as anxiety disorders and bipolar disorders as well as chronic back pain. Gabapentin prescriptions have increased markedly in recent years in the United States and in the United Kingdom. Recent studies suggest that gabapentin is misused when taken with other drugs, such as opioids, benzodiazepines (BZD) and Z-drugs. Although gabapentin is considered safe when used alone, concomitant use with the aforementioned drugs is dangerous and increases the risk of overdose. The aim of this research was to investigate the association between long-term use of opioids, BZD and Z-drugs and incident gabapentin use. The study included persons who contacted services of the Primary Health Care of the Capital Area in Iceland from January 2009 to December 2012. Information medical diagnoses (ICD-10 codes) were retrieved from the medical records database of the Primary Health Care of the Capital Area. Data on prescriptions for opioids, BZD and Z-drugs were obtained from the Prescription Medicines Register at the Directorate of Health. The subjects in the study were divided into four groups with respect to long-term (continous for three-years) use of defined daily dose (DDD) of opioids, BZD and Z-drugs and the incidence rate ratio (IRR) of gabapentin was assessed using Cox regression. The effect of certain chronic conditions and long-term use of SSRI drugs was also explored. Finally, the magnitude and duration of future gabapentin use was examined. The results showed that long-term use of opioids, BZD or Z-drugs was associated with increased risk of future gabapentin use. Individuals using opioids and equal or over 30 DDDs of BZD or Z-drugs were most likely to initiate gabapentin therapy (IRR 7.42; 95% CI 6.69-8.22). These individuals also had the longest average duration of future gabapentin ... |
author2 |
Háskóli Íslands |
format |
Master Thesis |
author |
Bjarni Páll Linnet Runólfsson 1996- |
author_facet |
Bjarni Páll Linnet Runólfsson 1996- |
author_sort |
Bjarni Páll Linnet Runólfsson 1996- |
title |
Association of incident gabapentin use: with long-term use of opioids, benzodiazepines and Z-drugs |
title_short |
Association of incident gabapentin use: with long-term use of opioids, benzodiazepines and Z-drugs |
title_full |
Association of incident gabapentin use: with long-term use of opioids, benzodiazepines and Z-drugs |
title_fullStr |
Association of incident gabapentin use: with long-term use of opioids, benzodiazepines and Z-drugs |
title_full_unstemmed |
Association of incident gabapentin use: with long-term use of opioids, benzodiazepines and Z-drugs |
title_sort |
association of incident gabapentin use: with long-term use of opioids, benzodiazepines and z-drugs |
publishDate |
2023 |
url |
http://hdl.handle.net/1946/44618 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://hdl.handle.net/1946/44618 |
_version_ |
1769007011875258368 |