Transcriptomic profiling of BRCA2 999del5 heterozygous cell lines

• Main Author: María Rose Bustos 1996-
• Other Authors: Háskóli Íslands
• Format: Thesis
• Language: English
• Published: 2020
• Subjects: Lífefna- og sameindalíffræði; Brjóstakrabbamein; Genarannsóknir; Kvenna; Iceland
• Online Access: http://hdl.handle.net/1946/35796

Breast cancer is the world's most common cancer diagnosed among women and it has been demonstrated that mutations in genes with roles in DNA repair pathways can vastly increase susceptibility for breast tumorigenesis. BRCA1 and BRCA2 are tumor suppressor genes which have roles in Homologous rec...