High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients
Studies on Icelandic breast cancer families have shown that most of them segregate a 999del5 BRCA2 mutation. Here, we report the frequency of the 999del5 BRCA2 mutation in an Icelandic control population and four different groups of cancer patients diagnosed with (a) breast cancer; (b) ovarian cance...
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1996
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ftskemman:oai:skemman.is:1946/20745 2023-05-15T16:47:10+02:00 High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients Sigurður Ingvarsson 1956- Guðrún Jóhannesdóttir 1957- Júlíus Guðmundsson 1968- Jón Þór Bergþórsson 1966- Aðalgeir Arason 1957- Bjarni A. Agnarsson 1952- Guðný Eiríksdóttir 1950- Óskar Þór Jóhannsson 1960- Borg, Åke Easton, Douglas F. Valgarður Egilsson 1940- Rósa Björk Barkardóttir 1958- Háskóli Íslands 1996-08 application/pdf http://hdl.handle.net/1946/20745 en eng http://cancerres.aacrjournals.org/content/56/16/3663.long http://www.ncbi.nlm.nih.gov/pubmed/8706004 https://www.researchgate.net/publication/14496354_High_prevalence_of_the_999del5_mutation_in_icelandic_breast_and_ovarian_cancer_patients Cancer Research, 1996, (56), 3663-3665 0008-5472 http://hdl.handle.net/1946/20745 Brjóstakrabbamein Article 1996 ftskemman 2022-12-11T06:56:11Z Studies on Icelandic breast cancer families have shown that most of them segregate a 999del5 BRCA2 mutation. Here, we report the frequency of the 999del5 BRCA2 mutation in an Icelandic control population and four different groups of cancer patients diagnosed with (a) breast cancer; (b) ovarian cancer; (c) prostate cancer (patients younger than 65 years); and (d) other cancer types, The proportions of individuals carrying the mutation were 0.4% in the control population and in the patient groups 8.5%, 7.9%, 2.7%, and 1.0%, respectively, Our results indicate that BRCA2 confers a very high risk of breast cancer and is responsible for a substantial fraction of breast and ovarian cancer in Iceland, but only a small proportion of other cancers. This work was supported by the Nordic Cancer Union, Science Fund of Iceland and the Memorial Fund of Bergthora Magnusdottir and Jakob B. Bjarnason. Article in Journal/Newspaper Iceland Skemman (Iceland) |
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Open Polar |
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Skemman (Iceland) |
op_collection_id |
ftskemman |
language |
English |
topic |
Brjóstakrabbamein |
spellingShingle |
Brjóstakrabbamein Sigurður Ingvarsson 1956- Guðrún Jóhannesdóttir 1957- Júlíus Guðmundsson 1968- Jón Þór Bergþórsson 1966- Aðalgeir Arason 1957- Bjarni A. Agnarsson 1952- Guðný Eiríksdóttir 1950- Óskar Þór Jóhannsson 1960- Borg, Åke Easton, Douglas F. Valgarður Egilsson 1940- Rósa Björk Barkardóttir 1958- High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients |
topic_facet |
Brjóstakrabbamein |
description |
Studies on Icelandic breast cancer families have shown that most of them segregate a 999del5 BRCA2 mutation. Here, we report the frequency of the 999del5 BRCA2 mutation in an Icelandic control population and four different groups of cancer patients diagnosed with (a) breast cancer; (b) ovarian cancer; (c) prostate cancer (patients younger than 65 years); and (d) other cancer types, The proportions of individuals carrying the mutation were 0.4% in the control population and in the patient groups 8.5%, 7.9%, 2.7%, and 1.0%, respectively, Our results indicate that BRCA2 confers a very high risk of breast cancer and is responsible for a substantial fraction of breast and ovarian cancer in Iceland, but only a small proportion of other cancers. This work was supported by the Nordic Cancer Union, Science Fund of Iceland and the Memorial Fund of Bergthora Magnusdottir and Jakob B. Bjarnason. |
author2 |
Háskóli Íslands |
format |
Article in Journal/Newspaper |
author |
Sigurður Ingvarsson 1956- Guðrún Jóhannesdóttir 1957- Júlíus Guðmundsson 1968- Jón Þór Bergþórsson 1966- Aðalgeir Arason 1957- Bjarni A. Agnarsson 1952- Guðný Eiríksdóttir 1950- Óskar Þór Jóhannsson 1960- Borg, Åke Easton, Douglas F. Valgarður Egilsson 1940- Rósa Björk Barkardóttir 1958- |
author_facet |
Sigurður Ingvarsson 1956- Guðrún Jóhannesdóttir 1957- Júlíus Guðmundsson 1968- Jón Þór Bergþórsson 1966- Aðalgeir Arason 1957- Bjarni A. Agnarsson 1952- Guðný Eiríksdóttir 1950- Óskar Þór Jóhannsson 1960- Borg, Åke Easton, Douglas F. Valgarður Egilsson 1940- Rósa Björk Barkardóttir 1958- |
author_sort |
Sigurður Ingvarsson 1956- |
title |
High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients |
title_short |
High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients |
title_full |
High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients |
title_fullStr |
High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients |
title_full_unstemmed |
High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients |
title_sort |
high prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients |
publishDate |
1996 |
url |
http://hdl.handle.net/1946/20745 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://cancerres.aacrjournals.org/content/56/16/3663.long http://www.ncbi.nlm.nih.gov/pubmed/8706004 https://www.researchgate.net/publication/14496354_High_prevalence_of_the_999del5_mutation_in_icelandic_breast_and_ovarian_cancer_patients Cancer Research, 1996, (56), 3663-3665 0008-5472 http://hdl.handle.net/1946/20745 |
_version_ |
1766037247284477952 |