Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype
Cloning of a breast cancer-predisposing gene (BRCA2) on chromosome 13Q12-14 has been reported recently. We analyzed seven large Icelandic breast cancer families with markers from the BRCA2 region. Five families showed strong evidence of linkage. The maximum two-point LOD scores for the five BRCA2-li...
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ftskemman:oai:skemman.is:1946/20740 2023-05-15T16:46:19+02:00 Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype Sigurður Ingvarsson 1956- Júlíus Guðmundsson 1968- Guðrún Jóhannesdóttir 1957- Aðalgeir Arason 1957- Jón Þór Bergþórsson 1966- Valgarður Egilsson 1940- Rósa Björk Barkardóttir 1958- Háskóli Íslands 1996-04 application/pdf http://hdl.handle.net/1946/20740 en eng http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1914693&blobtype=pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914693/pdf/ajhg00017-0106.pdf http://www.ncbi.nlm.nih.gov/pubmed/8644738 https://www.researchgate.net/publication/14555302_Frequent_occurrence_of_BRCA2_linkage_in_Icelandic_breast_cancer_families_and_segregation_of_a_common_BRCA2_haplotype American Journal of Human Genetics, 1996 (58), 749-756 0002-9297 http://hdl.handle.net/1946/20740 Brjóstakrabbamein Article 1996 ftskemman 2022-12-11T06:50:11Z Cloning of a breast cancer-predisposing gene (BRCA2) on chromosome 13Q12-14 has been reported recently. We analyzed seven large Icelandic breast cancer families with markers from the BRCA2 region. Five families showed strong evidence of linkage. The maximum two-point LOD scores for the five BRCA2-linked families ranged from 1.06 to 3.19. Haplotype analyses revealed a region with identical allele sizes between the families, suggesting that they have inherited the mutation from a common ancestor. Cancer types other than breast cancer occur in individuals, segregating the affected haplotype within these families. This suggests that mutations in the gene may also confer some risk of other malignancies in both males and females. This work was financially supported by the Nordic Cancer Union, the Science Fund of Iceland, the Icelandic Cancer Society Research Fund, the University of Iceland Graduate Research Fund, the Science Fund of the University Hospital of Iceland, and the Memorial Fund of Bergthora Magnusdottir and Jakob B. Bjarnason. Article in Journal/Newspaper Iceland Skemman (Iceland) |
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Skemman (Iceland) |
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ftskemman |
language |
English |
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Brjóstakrabbamein |
spellingShingle |
Brjóstakrabbamein Sigurður Ingvarsson 1956- Júlíus Guðmundsson 1968- Guðrún Jóhannesdóttir 1957- Aðalgeir Arason 1957- Jón Þór Bergþórsson 1966- Valgarður Egilsson 1940- Rósa Björk Barkardóttir 1958- Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype |
topic_facet |
Brjóstakrabbamein |
description |
Cloning of a breast cancer-predisposing gene (BRCA2) on chromosome 13Q12-14 has been reported recently. We analyzed seven large Icelandic breast cancer families with markers from the BRCA2 region. Five families showed strong evidence of linkage. The maximum two-point LOD scores for the five BRCA2-linked families ranged from 1.06 to 3.19. Haplotype analyses revealed a region with identical allele sizes between the families, suggesting that they have inherited the mutation from a common ancestor. Cancer types other than breast cancer occur in individuals, segregating the affected haplotype within these families. This suggests that mutations in the gene may also confer some risk of other malignancies in both males and females. This work was financially supported by the Nordic Cancer Union, the Science Fund of Iceland, the Icelandic Cancer Society Research Fund, the University of Iceland Graduate Research Fund, the Science Fund of the University Hospital of Iceland, and the Memorial Fund of Bergthora Magnusdottir and Jakob B. Bjarnason. |
author2 |
Háskóli Íslands |
format |
Article in Journal/Newspaper |
author |
Sigurður Ingvarsson 1956- Júlíus Guðmundsson 1968- Guðrún Jóhannesdóttir 1957- Aðalgeir Arason 1957- Jón Þór Bergþórsson 1966- Valgarður Egilsson 1940- Rósa Björk Barkardóttir 1958- |
author_facet |
Sigurður Ingvarsson 1956- Júlíus Guðmundsson 1968- Guðrún Jóhannesdóttir 1957- Aðalgeir Arason 1957- Jón Þór Bergþórsson 1966- Valgarður Egilsson 1940- Rósa Björk Barkardóttir 1958- |
author_sort |
Sigurður Ingvarsson 1956- |
title |
Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype |
title_short |
Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype |
title_full |
Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype |
title_fullStr |
Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype |
title_full_unstemmed |
Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype |
title_sort |
frequent occurrence of brca2 linkage in icelandic breast cancer families and segregation of a common brca2 haplotype |
publishDate |
1996 |
url |
http://hdl.handle.net/1946/20740 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1914693&blobtype=pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914693/pdf/ajhg00017-0106.pdf http://www.ncbi.nlm.nih.gov/pubmed/8644738 https://www.researchgate.net/publication/14555302_Frequent_occurrence_of_BRCA2_linkage_in_Icelandic_breast_cancer_families_and_segregation_of_a_common_BRCA2_haplotype American Journal of Human Genetics, 1996 (58), 749-756 0002-9297 http://hdl.handle.net/1946/20740 |
_version_ |
1766036415519391744 |