Dynamic Links between Lipid Storage, Toxicokinetics and Mortality in a Marine Copepod Exposed to Dimethylnaphthalene
Efficiently assessing and managing the risks of pollution in the marine environment requires mechanistic models for toxic effects. The General Unified Threshold model for Survival (GUTS) provides a framework for deriving toxicokinetic-toxicodynamic (TKTD) models for the end point survival. Two recur...
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Online Access: | http://hdl.handle.net/11250/2488997 https://doi.org/10.1021/acs.est.7b02212 |
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ftsintef:oai:sintef.brage.unit.no:11250/2488997 2023-05-15T15:48:00+02:00 Dynamic Links between Lipid Storage, Toxicokinetics and Mortality in a Marine Copepod Exposed to Dimethylnaphthalene Jager, Tjalling Øverjordet, Ida Beathe Nepstad, Raymond Hansen, Bjørn Henrik 2017-06-17 application/pdf http://hdl.handle.net/11250/2488997 https://doi.org/10.1021/acs.est.7b02212 eng eng Norges forskningsråd: 225314 Environmental Science and Technology. 2017, 51 (13), 7707-7713. urn:issn:0013-936X http://hdl.handle.net/11250/2488997 https://doi.org/10.1021/acs.est.7b02212 cristin:1520968 Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no Accepted manuscript © The Author(s) 2017 CC-BY-NC-ND 7707-7713 51 Environmental Science and Technology 13 Journal article Peer reviewed 2017 ftsintef https://doi.org/10.1021/acs.est.7b02212 2021-08-04T11:59:29Z Efficiently assessing and managing the risks of pollution in the marine environment requires mechanistic models for toxic effects. The General Unified Threshold model for Survival (GUTS) provides a framework for deriving toxicokinetic-toxicodynamic (TKTD) models for the end point survival. Two recurring questions in the application of GUTS concern the most appropriate death mechanism, and whether the total body residue is a proper dose metric for toxic effects. We address these questions with a case study for dimethylnaphthalene in the marine copepod Calanus finmarchicus. A detailed analysis revealed that body residues were best explained by representing copepods with two toxicokinetic compartments: separating structural biomass and lipid storage. Toxicity is most likely related to the concentration in structure, which led to identification of “stochastic death” as the most appropriate death mechanism. Interestingly, the parametrized model predicts that lipid content will have only minor influence on short-term toxicity. However, the toxicants stored in lipids may have more substantial impacts in situations not included in our experiments (e.g., during diapause and gonad maturation), and for contaminant transfer to eggs and copepod predators. acceptedVersion Article in Journal/Newspaper Calanus finmarchicus Copepods SINTEF Open (Brage) Environmental Science & Technology 51 13 7707 7713 |
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language |
English |
description |
Efficiently assessing and managing the risks of pollution in the marine environment requires mechanistic models for toxic effects. The General Unified Threshold model for Survival (GUTS) provides a framework for deriving toxicokinetic-toxicodynamic (TKTD) models for the end point survival. Two recurring questions in the application of GUTS concern the most appropriate death mechanism, and whether the total body residue is a proper dose metric for toxic effects. We address these questions with a case study for dimethylnaphthalene in the marine copepod Calanus finmarchicus. A detailed analysis revealed that body residues were best explained by representing copepods with two toxicokinetic compartments: separating structural biomass and lipid storage. Toxicity is most likely related to the concentration in structure, which led to identification of “stochastic death” as the most appropriate death mechanism. Interestingly, the parametrized model predicts that lipid content will have only minor influence on short-term toxicity. However, the toxicants stored in lipids may have more substantial impacts in situations not included in our experiments (e.g., during diapause and gonad maturation), and for contaminant transfer to eggs and copepod predators. acceptedVersion |
format |
Article in Journal/Newspaper |
author |
Jager, Tjalling Øverjordet, Ida Beathe Nepstad, Raymond Hansen, Bjørn Henrik |
spellingShingle |
Jager, Tjalling Øverjordet, Ida Beathe Nepstad, Raymond Hansen, Bjørn Henrik Dynamic Links between Lipid Storage, Toxicokinetics and Mortality in a Marine Copepod Exposed to Dimethylnaphthalene |
author_facet |
Jager, Tjalling Øverjordet, Ida Beathe Nepstad, Raymond Hansen, Bjørn Henrik |
author_sort |
Jager, Tjalling |
title |
Dynamic Links between Lipid Storage, Toxicokinetics and Mortality in a Marine Copepod Exposed to Dimethylnaphthalene |
title_short |
Dynamic Links between Lipid Storage, Toxicokinetics and Mortality in a Marine Copepod Exposed to Dimethylnaphthalene |
title_full |
Dynamic Links between Lipid Storage, Toxicokinetics and Mortality in a Marine Copepod Exposed to Dimethylnaphthalene |
title_fullStr |
Dynamic Links between Lipid Storage, Toxicokinetics and Mortality in a Marine Copepod Exposed to Dimethylnaphthalene |
title_full_unstemmed |
Dynamic Links between Lipid Storage, Toxicokinetics and Mortality in a Marine Copepod Exposed to Dimethylnaphthalene |
title_sort |
dynamic links between lipid storage, toxicokinetics and mortality in a marine copepod exposed to dimethylnaphthalene |
publishDate |
2017 |
url |
http://hdl.handle.net/11250/2488997 https://doi.org/10.1021/acs.est.7b02212 |
genre |
Calanus finmarchicus Copepods |
genre_facet |
Calanus finmarchicus Copepods |
op_source |
7707-7713 51 Environmental Science and Technology 13 |
op_relation |
Norges forskningsråd: 225314 Environmental Science and Technology. 2017, 51 (13), 7707-7713. urn:issn:0013-936X http://hdl.handle.net/11250/2488997 https://doi.org/10.1021/acs.est.7b02212 cristin:1520968 |
op_rights |
Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no Accepted manuscript © The Author(s) 2017 |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1021/acs.est.7b02212 |
container_title |
Environmental Science & Technology |
container_volume |
51 |
container_issue |
13 |
container_start_page |
7707 |
op_container_end_page |
7713 |
_version_ |
1766382986379395072 |