Co-morbidity and drug treatment in Alzheimer’s disease. A cross sectional study of participants in the Dementia Study in Northern Norway
Beskriver en studie hvor hensikten var å sammenligne legemiddelbruk mellom eldre diagnostisert med Alzheimers sykdom og en gruppe kognitivt friske eldre. Fokus på komorbiditet og uhensiktsmessig legemiddelbruk. Background Inappropriate medical treatment of co-morbidities in Alzheimer's disease...
Published in: | BMC Geriatrics |
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Online Access: | http://hdl.handle.net/11250/2445227 https://doi.org/10.1186/1471-2318-11-58 |
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ftsfomsorgsforsk:oai:omsorgsforskning.brage.unit.no:11250/2445227 2024-03-03T08:47:23+00:00 Co-morbidity and drug treatment in Alzheimer’s disease. A cross sectional study of participants in the Dementia Study in Northern Norway Andersen, Fred Viitanen, Matti Halvorsen, Dag S. Straume, Bjørn Engstad, Torgeir A. 2011 application/pdf http://hdl.handle.net/11250/2445227 https://doi.org/10.1186/1471-2318-11-58 eng eng Andersen, F., Viitanen, M., Halvorsen, D.S., Straume, B. & Engstad, T.A. (2011) Co-morbidity and drug treatment in Alzheimer’s disease: a cross sectional study of participants in the Dementia Study in Northern Norway. BMC Geriatrics, 11(58). doi:10.1186/1471-2318-11-58 http://hdl.handle.net/11250/2445227 https://doi.org/10.1186/1471-2318-11-58 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no Andersen, Fred 11 BMC Geriatrics 58 pasientsikkerhet legemiddel legemiddelbruk legemiddelbehandling legemiddelrelaterte problemer legemiddelinteraksjoner legemiddelforskrivning uhensiktsmessig legemiddelbruk hjemmeboende eldre sykehjem demens Alzheimer komorbiditet kognitiv funksjon screening kartlegging regresjonsmodell sammenlignende studie tverrsnitt tverrsnittstudie Norge Journal article 2011 ftsfomsorgsforsk https://doi.org/10.1186/1471-2318-11-58 2024-02-02T11:37:29Z Beskriver en studie hvor hensikten var å sammenligne legemiddelbruk mellom eldre diagnostisert med Alzheimers sykdom og en gruppe kognitivt friske eldre. Fokus på komorbiditet og uhensiktsmessig legemiddelbruk. Background Inappropriate medical treatment of co-morbidities in Alzheimer's disease (AD) is an increasing concern in geriatric medicine. The objective of this study was to compare current drug use related to co-morbidity between individuals with a recent diagnosis of AD and a cognitively healthy control group in a population based clinical trial in Northern Norway. Methods Setting: Nine rural municipalities with 70 000 inhabitants in Northern Norway. Participants: Participants with and without AD recruited in general practice and by population based screening. 187 participants with a recent diagnosis of AD were recruited among community dwellers. Of 791 respondents without cognitive symptoms, 500 were randomly selected and invited to further clinical and cognitive testing. The final control group consisted of 200 cognitively healthy individuals from the same municipalities. Demographic characteristics, data on medical history and current medication were included, and a physical and cognitive examination was performed. The statistical analyses were carried out by independent sample t-test, chi-square, ANCOVA and logistic regression. Results A co-morbidity score was significantly higher in AD participants compared to controls. The mean number of drugs was higher for AD participants compared to controls (5.1 ± 3.6 and 2.9 ± 2.4 respectively, p < 0.001 age and gender adjusted), also when adjusted for co-morbidity. AD participants used significantly more anticholinergic, sedative and antidepressant drugs. For nursing home residents with AD the mean number of drugs was significantly higher compared to AD participants living at home (6.9 ± 3.9 and 4.5 ± 3.3, respectively, p < 0.001). Conclusions AD participants were treated with a significantly higher number of drugs as compared to cognitively healthy ... Article in Journal/Newspaper Northern Norway Senter for omsorgsforskning: Omsorgsbiblioteket Norway BMC Geriatrics 11 1 |
institution |
Open Polar |
collection |
Senter for omsorgsforskning: Omsorgsbiblioteket |
op_collection_id |
ftsfomsorgsforsk |
language |
English |
topic |
pasientsikkerhet legemiddel legemiddelbruk legemiddelbehandling legemiddelrelaterte problemer legemiddelinteraksjoner legemiddelforskrivning uhensiktsmessig legemiddelbruk hjemmeboende eldre sykehjem demens Alzheimer komorbiditet kognitiv funksjon screening kartlegging regresjonsmodell sammenlignende studie tverrsnitt tverrsnittstudie Norge |
spellingShingle |
pasientsikkerhet legemiddel legemiddelbruk legemiddelbehandling legemiddelrelaterte problemer legemiddelinteraksjoner legemiddelforskrivning uhensiktsmessig legemiddelbruk hjemmeboende eldre sykehjem demens Alzheimer komorbiditet kognitiv funksjon screening kartlegging regresjonsmodell sammenlignende studie tverrsnitt tverrsnittstudie Norge Andersen, Fred Viitanen, Matti Halvorsen, Dag S. Straume, Bjørn Engstad, Torgeir A. Co-morbidity and drug treatment in Alzheimer’s disease. A cross sectional study of participants in the Dementia Study in Northern Norway |
topic_facet |
pasientsikkerhet legemiddel legemiddelbruk legemiddelbehandling legemiddelrelaterte problemer legemiddelinteraksjoner legemiddelforskrivning uhensiktsmessig legemiddelbruk hjemmeboende eldre sykehjem demens Alzheimer komorbiditet kognitiv funksjon screening kartlegging regresjonsmodell sammenlignende studie tverrsnitt tverrsnittstudie Norge |
description |
Beskriver en studie hvor hensikten var å sammenligne legemiddelbruk mellom eldre diagnostisert med Alzheimers sykdom og en gruppe kognitivt friske eldre. Fokus på komorbiditet og uhensiktsmessig legemiddelbruk. Background Inappropriate medical treatment of co-morbidities in Alzheimer's disease (AD) is an increasing concern in geriatric medicine. The objective of this study was to compare current drug use related to co-morbidity between individuals with a recent diagnosis of AD and a cognitively healthy control group in a population based clinical trial in Northern Norway. Methods Setting: Nine rural municipalities with 70 000 inhabitants in Northern Norway. Participants: Participants with and without AD recruited in general practice and by population based screening. 187 participants with a recent diagnosis of AD were recruited among community dwellers. Of 791 respondents without cognitive symptoms, 500 were randomly selected and invited to further clinical and cognitive testing. The final control group consisted of 200 cognitively healthy individuals from the same municipalities. Demographic characteristics, data on medical history and current medication were included, and a physical and cognitive examination was performed. The statistical analyses were carried out by independent sample t-test, chi-square, ANCOVA and logistic regression. Results A co-morbidity score was significantly higher in AD participants compared to controls. The mean number of drugs was higher for AD participants compared to controls (5.1 ± 3.6 and 2.9 ± 2.4 respectively, p < 0.001 age and gender adjusted), also when adjusted for co-morbidity. AD participants used significantly more anticholinergic, sedative and antidepressant drugs. For nursing home residents with AD the mean number of drugs was significantly higher compared to AD participants living at home (6.9 ± 3.9 and 4.5 ± 3.3, respectively, p < 0.001). Conclusions AD participants were treated with a significantly higher number of drugs as compared to cognitively healthy ... |
format |
Article in Journal/Newspaper |
author |
Andersen, Fred Viitanen, Matti Halvorsen, Dag S. Straume, Bjørn Engstad, Torgeir A. |
author_facet |
Andersen, Fred Viitanen, Matti Halvorsen, Dag S. Straume, Bjørn Engstad, Torgeir A. |
author_sort |
Andersen, Fred |
title |
Co-morbidity and drug treatment in Alzheimer’s disease. A cross sectional study of participants in the Dementia Study in Northern Norway |
title_short |
Co-morbidity and drug treatment in Alzheimer’s disease. A cross sectional study of participants in the Dementia Study in Northern Norway |
title_full |
Co-morbidity and drug treatment in Alzheimer’s disease. A cross sectional study of participants in the Dementia Study in Northern Norway |
title_fullStr |
Co-morbidity and drug treatment in Alzheimer’s disease. A cross sectional study of participants in the Dementia Study in Northern Norway |
title_full_unstemmed |
Co-morbidity and drug treatment in Alzheimer’s disease. A cross sectional study of participants in the Dementia Study in Northern Norway |
title_sort |
co-morbidity and drug treatment in alzheimer’s disease. a cross sectional study of participants in the dementia study in northern norway |
publishDate |
2011 |
url |
http://hdl.handle.net/11250/2445227 https://doi.org/10.1186/1471-2318-11-58 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Northern Norway |
genre_facet |
Northern Norway |
op_source |
11 BMC Geriatrics 58 |
op_relation |
Andersen, F., Viitanen, M., Halvorsen, D.S., Straume, B. & Engstad, T.A. (2011) Co-morbidity and drug treatment in Alzheimer’s disease: a cross sectional study of participants in the Dementia Study in Northern Norway. BMC Geriatrics, 11(58). doi:10.1186/1471-2318-11-58 http://hdl.handle.net/11250/2445227 https://doi.org/10.1186/1471-2318-11-58 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no Andersen, Fred |
op_doi |
https://doi.org/10.1186/1471-2318-11-58 |
container_title |
BMC Geriatrics |
container_volume |
11 |
container_issue |
1 |
_version_ |
1792503558004801536 |