Alternative Animal Models of Aging Research
Most research on mechanisms of aging is being conducted in a very limited number of classical model species, i.e., laboratory mouse (Mus musculus), rat (Rattus norvegicus domestica), the common fruit fly (Drosophila melanogaster) and roundworm (Caenorhabditis elegans). The obvious advantages of usin...
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Online Access: | http://hdl.handle.net/11384/104486 https://doi.org/10.3389/fmolb.2021.660959 |
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ftscnormpisairis:oai:ricerca.sns.it:11384/104486 2024-04-21T07:56:07+00:00 Alternative Animal Models of Aging Research Holtze, Susanne Gorshkova, Ekaterina Braude, Stan Cellerino, Alessandro Dammann, Philip Hildebrandt, Thomas B. Hoeflich, Andreas Hoffmann, Steve Koch, Philipp Terzibasi Tozzini, Eva Skulachev, Maxim Skulachev, Vladimir P. Sahm, Arne Holtze, Susanne Gorshkova, Ekaterina Braude, Stan Cellerino, Alessandro Dammann, Philip Hildebrandt, Thomas B. Hoeflich, Andrea Hoffmann, Steve Koch, Philipp Terzibasi Tozzini, Eva Skulachev, Maxim Skulachev, Vladimir P. Sahm, Arne 2021 http://hdl.handle.net/11384/104486 https://doi.org/10.3389/fmolb.2021.660959 eng eng info:eu-repo/semantics/altIdentifier/wos/WOS:000656133600001 volume:8 journal:FRONTIERS IN MOLECULAR BIOSCIENCES http://hdl.handle.net/11384/104486 doi:10.3389/fmolb.2021.660959 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85107068258 info:eu-repo/semantics/openAccess Greenland shark Heterocephalus glaber Hydra oligacti Myoti Nothobranchius furzeri Proteus anguinu resistance to cancer Senescence Settore BIO/09 - Fisiologia info:eu-repo/semantics/article 2021 ftscnormpisairis https://doi.org/10.3389/fmolb.2021.660959 2024-03-28T01:17:13Z Most research on mechanisms of aging is being conducted in a very limited number of classical model species, i.e., laboratory mouse (Mus musculus), rat (Rattus norvegicus domestica), the common fruit fly (Drosophila melanogaster) and roundworm (Caenorhabditis elegans). The obvious advantages of using these models are access to resources such as strains with known genetic properties, high-quality genomic and transcriptomic sequencing data, versatile experimental manipulation capabilities including well-established genome editing tools, as well as extensive experience in husbandry. However, this approach may introduce interpretation biases due to the specific characteristics of the investigated species, which may lead to inappropriate, or even false, generalization. For example, it is still unclear to what extent knowledge of aging mechanisms gained in short-lived model organisms is transferable to long-lived species such as humans. In addition, other specific adaptations favoring a long and healthy life from the immense evolutionary toolbox may be entirely missed. In this review, we summarize the specific characteristics of emerging animal models that have attracted the attention of gerontologists, we provide an overview of the available data and resources related to these models, and we summarize important insights gained from them in recent years. The models presented include short-lived ones such as killifish (Nothobranchius furzeri), long-lived ones such as primates (Callithrix jacchus, Cebus imitator, Macaca mulatta), bathyergid mole-rats (Heterocephalus glaber, Fukomys spp.), bats (Myotis spp.), birds, olms (Proteus anguinus), turtles, greenland sharks, bivalves (Arctica islandica), and potentially non-aging ones such as Hydra and Planaria. Article in Journal/Newspaper Arctica islandica Greenland Scuola Normale Superiore: CINECA IRIS Frontiers in Molecular Biosciences 8 |
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Open Polar |
collection |
Scuola Normale Superiore: CINECA IRIS |
op_collection_id |
ftscnormpisairis |
language |
English |
topic |
Greenland shark Heterocephalus glaber Hydra oligacti Myoti Nothobranchius furzeri Proteus anguinu resistance to cancer Senescence Settore BIO/09 - Fisiologia |
spellingShingle |
Greenland shark Heterocephalus glaber Hydra oligacti Myoti Nothobranchius furzeri Proteus anguinu resistance to cancer Senescence Settore BIO/09 - Fisiologia Holtze, Susanne Gorshkova, Ekaterina Braude, Stan Cellerino, Alessandro Dammann, Philip Hildebrandt, Thomas B. Hoeflich, Andreas Hoffmann, Steve Koch, Philipp Terzibasi Tozzini, Eva Skulachev, Maxim Skulachev, Vladimir P. Sahm, Arne Alternative Animal Models of Aging Research |
topic_facet |
Greenland shark Heterocephalus glaber Hydra oligacti Myoti Nothobranchius furzeri Proteus anguinu resistance to cancer Senescence Settore BIO/09 - Fisiologia |
description |
Most research on mechanisms of aging is being conducted in a very limited number of classical model species, i.e., laboratory mouse (Mus musculus), rat (Rattus norvegicus domestica), the common fruit fly (Drosophila melanogaster) and roundworm (Caenorhabditis elegans). The obvious advantages of using these models are access to resources such as strains with known genetic properties, high-quality genomic and transcriptomic sequencing data, versatile experimental manipulation capabilities including well-established genome editing tools, as well as extensive experience in husbandry. However, this approach may introduce interpretation biases due to the specific characteristics of the investigated species, which may lead to inappropriate, or even false, generalization. For example, it is still unclear to what extent knowledge of aging mechanisms gained in short-lived model organisms is transferable to long-lived species such as humans. In addition, other specific adaptations favoring a long and healthy life from the immense evolutionary toolbox may be entirely missed. In this review, we summarize the specific characteristics of emerging animal models that have attracted the attention of gerontologists, we provide an overview of the available data and resources related to these models, and we summarize important insights gained from them in recent years. The models presented include short-lived ones such as killifish (Nothobranchius furzeri), long-lived ones such as primates (Callithrix jacchus, Cebus imitator, Macaca mulatta), bathyergid mole-rats (Heterocephalus glaber, Fukomys spp.), bats (Myotis spp.), birds, olms (Proteus anguinus), turtles, greenland sharks, bivalves (Arctica islandica), and potentially non-aging ones such as Hydra and Planaria. |
author2 |
Holtze, Susanne Gorshkova, Ekaterina Braude, Stan Cellerino, Alessandro Dammann, Philip Hildebrandt, Thomas B. Hoeflich, Andrea Hoffmann, Steve Koch, Philipp Terzibasi Tozzini, Eva Skulachev, Maxim Skulachev, Vladimir P. Sahm, Arne |
format |
Article in Journal/Newspaper |
author |
Holtze, Susanne Gorshkova, Ekaterina Braude, Stan Cellerino, Alessandro Dammann, Philip Hildebrandt, Thomas B. Hoeflich, Andreas Hoffmann, Steve Koch, Philipp Terzibasi Tozzini, Eva Skulachev, Maxim Skulachev, Vladimir P. Sahm, Arne |
author_facet |
Holtze, Susanne Gorshkova, Ekaterina Braude, Stan Cellerino, Alessandro Dammann, Philip Hildebrandt, Thomas B. Hoeflich, Andreas Hoffmann, Steve Koch, Philipp Terzibasi Tozzini, Eva Skulachev, Maxim Skulachev, Vladimir P. Sahm, Arne |
author_sort |
Holtze, Susanne |
title |
Alternative Animal Models of Aging Research |
title_short |
Alternative Animal Models of Aging Research |
title_full |
Alternative Animal Models of Aging Research |
title_fullStr |
Alternative Animal Models of Aging Research |
title_full_unstemmed |
Alternative Animal Models of Aging Research |
title_sort |
alternative animal models of aging research |
publishDate |
2021 |
url |
http://hdl.handle.net/11384/104486 https://doi.org/10.3389/fmolb.2021.660959 |
genre |
Arctica islandica Greenland |
genre_facet |
Arctica islandica Greenland |
op_relation |
info:eu-repo/semantics/altIdentifier/wos/WOS:000656133600001 volume:8 journal:FRONTIERS IN MOLECULAR BIOSCIENCES http://hdl.handle.net/11384/104486 doi:10.3389/fmolb.2021.660959 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85107068258 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3389/fmolb.2021.660959 |
container_title |
Frontiers in Molecular Biosciences |
container_volume |
8 |
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1796938260049559552 |