Repositioning of the global epicentre of non-optimal cholesterol

• Published in: Nature
• Main Authors: NCD Risk Factor Collaboration (NCD-RisC), Plans-Rubió, Pedro
• Other Authors: Plans-Rubió P Agència de Salut Pública de Catalunya, Departament de Salut, Generalitat de Catalunya, Barcelona, Spain, Departament de Salut
• Format: Article in Journal/Newspaper
• Language: English
• Published: Nature Publishing Group 2020
• Subjects: Hipercolesterolèmia - Epidemiologia; Malalties coronàries - Epidemiologia; Salut mundial; PUBLIC HEALTH::Health Care (Public Health)::Health of Specific Groups::Global Health; DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias::Hyperlipidemias::Hypercholesterolemia; Other subheadings::Other subheadings::Other subheadings::/epidemiology; DISEASES::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia; SALUD PÚBLICA::atención a la salud (salud pública)::salud de grupos específicos::salud global; ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de los lípidos::dislipidemias::hiperlipidemias::hipercolesterolemia; Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología; ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::isquemia miocárdica; Greenland; Pacific; Norway; Iceland
• Online Access: https://hdl.handle.net/11351/11420; https://doi.org/10.1038/s41586-020-2338-1

Colesterol; Medicaments hipolipemiants; Isquèmia miocàrdica Colesterol; Medicamentos hipolipemiantes; Isquemia miocárdica Cholesterol; Lipid-lowering medications; Myocardial Ischemia High blood cholesterol is typically considered a feature of wealthy western countries. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects ...