Dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the Far Eastern federal district [Динамика реализации фиксированных комбинаций для лечения артериальной гипертензии в аптечных организациях южных районов Дальневосточного федерального округа]
Background. Advantages of the two-component drugs are well-known and described in the professional standards and guidelines. However, in clinical practice their application is often limited, despite the increase in the variants of full-doses combinations. Objective. To analyze the dynamics of sales...
Published in: | "Arterial’naya Gipertenziya" ("Arterial Hypertension") |
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All-Russian Public Organization Antihypertensive League
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ftrudnuniv:oai:repository.rudn.ru:r/36410 2023-05-15T18:09:17+02:00 Dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the Far Eastern federal district [Динамика реализации фиксированных комбинаций для лечения артериальной гипертензии в аптечных организациях южных районов Дальневосточного федерального округа] Soboleva M.S. Loskutova E.E. https://repository.rudn.ru/records/article/record/36410/ RU rus All-Russian Public Organization Antihypertensive League https://doi.org/10.18705/1607-419X-2018-24-4-469-477 https://repository.rudn.ru/records/article/record/36410/ Arterial Hypertension (Russian Federation) Hypertension Pharmacoepidemiology study The Far Eastern federal district The fixed-doses combinations The pharmaceutical market Article ftrudnuniv https://doi.org/10.18705/1607-419X-2018-24-4-469-477 2022-01-03T08:53:18Z Background. Advantages of the two-component drugs are well-known and described in the professional standards and guidelines. However, in clinical practice their application is often limited, despite the increase in the variants of full-doses combinations. Objective. To analyze the dynamics of sales of the fixed-doses antihypertensive combinations in regions of the Far Eastern federal district. Design and methods. We present the results of the pharmacoepidemiological studs of the regional pharmaceutical market of the antihypertensive fixed-doses combinations in Khabarovskii, Primorskii region and the Sakhalin region in 2015-2017. Results. In the studied regions of the Russian Federation, combinations of angiotensin-converting-enzyme inhibitors and diuretics are the most popular. Leading ones appeared to be enalapril + hydrochlorothiazide and Perindopril + indapamide. Combinations of angiotensin-converting-enzyme inhibitors with dihydropyridine derivatives calcium channel blockers were acquired seldom. The most popular combinations were Perindopril + amlodipine and lizinopril + amlodipine. Among combinations of angiotensin II antagonists with diuretics losartan + hydrochlorothiazide and valsartan + hydrochlorothiazide showed the greatest sales. Combinations including sartan and calcium channel blockers were acquired more seldom, despite the wide range of international non-proprietary variants in drugstores. Atenolol + chlortalidone was in the most popular demand among combinations of β-blockers with diuretics. In 2016 three-component combinations were presented by only four trade names, and their demand is still limited. Nevertheless, a nonsignificant growth of purchases was observed. Conclusions. Our data show low demand of fixed-doses combinations. In regions, as a rule, there is an increase in sales of generic more affordable combinations which proves the significance of both antihypertensive efficiency and the price. © 2018 All-Russian Public Organization Antihypertensive League. All Rights Reserved. Article in Journal/Newspaper Sakhalin Peoples' Friendship University of Russia (RUDN): Open repository "Arterial’naya Gipertenziya" ("Arterial Hypertension") 24 4 469 477 |
institution |
Open Polar |
collection |
Peoples' Friendship University of Russia (RUDN): Open repository |
op_collection_id |
ftrudnuniv |
language |
Russian |
topic |
Hypertension Pharmacoepidemiology study The Far Eastern federal district The fixed-doses combinations The pharmaceutical market |
spellingShingle |
Hypertension Pharmacoepidemiology study The Far Eastern federal district The fixed-doses combinations The pharmaceutical market Soboleva M.S. Loskutova E.E. Dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the Far Eastern federal district [Динамика реализации фиксированных комбинаций для лечения артериальной гипертензии в аптечных организациях южных районов Дальневосточного федерального округа] |
topic_facet |
Hypertension Pharmacoepidemiology study The Far Eastern federal district The fixed-doses combinations The pharmaceutical market |
description |
Background. Advantages of the two-component drugs are well-known and described in the professional standards and guidelines. However, in clinical practice their application is often limited, despite the increase in the variants of full-doses combinations. Objective. To analyze the dynamics of sales of the fixed-doses antihypertensive combinations in regions of the Far Eastern federal district. Design and methods. We present the results of the pharmacoepidemiological studs of the regional pharmaceutical market of the antihypertensive fixed-doses combinations in Khabarovskii, Primorskii region and the Sakhalin region in 2015-2017. Results. In the studied regions of the Russian Federation, combinations of angiotensin-converting-enzyme inhibitors and diuretics are the most popular. Leading ones appeared to be enalapril + hydrochlorothiazide and Perindopril + indapamide. Combinations of angiotensin-converting-enzyme inhibitors with dihydropyridine derivatives calcium channel blockers were acquired seldom. The most popular combinations were Perindopril + amlodipine and lizinopril + amlodipine. Among combinations of angiotensin II antagonists with diuretics losartan + hydrochlorothiazide and valsartan + hydrochlorothiazide showed the greatest sales. Combinations including sartan and calcium channel blockers were acquired more seldom, despite the wide range of international non-proprietary variants in drugstores. Atenolol + chlortalidone was in the most popular demand among combinations of β-blockers with diuretics. In 2016 three-component combinations were presented by only four trade names, and their demand is still limited. Nevertheless, a nonsignificant growth of purchases was observed. Conclusions. Our data show low demand of fixed-doses combinations. In regions, as a rule, there is an increase in sales of generic more affordable combinations which proves the significance of both antihypertensive efficiency and the price. © 2018 All-Russian Public Organization Antihypertensive League. All Rights Reserved. |
format |
Article in Journal/Newspaper |
author |
Soboleva M.S. Loskutova E.E. |
author_facet |
Soboleva M.S. Loskutova E.E. |
author_sort |
Soboleva M.S. |
title |
Dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the Far Eastern federal district [Динамика реализации фиксированных комбинаций для лечения артериальной гипертензии в аптечных организациях южных районов Дальневосточного федерального округа] |
title_short |
Dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the Far Eastern federal district [Динамика реализации фиксированных комбинаций для лечения артериальной гипертензии в аптечных организациях южных районов Дальневосточного федерального округа] |
title_full |
Dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the Far Eastern federal district [Динамика реализации фиксированных комбинаций для лечения артериальной гипертензии в аптечных организациях южных районов Дальневосточного федерального округа] |
title_fullStr |
Dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the Far Eastern federal district [Динамика реализации фиксированных комбинаций для лечения артериальной гипертензии в аптечных организациях южных районов Дальневосточного федерального округа] |
title_full_unstemmed |
Dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the Far Eastern federal district [Динамика реализации фиксированных комбинаций для лечения артериальной гипертензии в аптечных организациях южных районов Дальневосточного федерального округа] |
title_sort |
dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the far eastern federal district [динамика реализации фиксированных комбинаций для лечения артериальной гипертензии в аптечных организациях южных районов дальневосточного федерального округа] |
publisher |
All-Russian Public Organization Antihypertensive League |
url |
https://repository.rudn.ru/records/article/record/36410/ |
genre |
Sakhalin |
genre_facet |
Sakhalin |
op_source |
Arterial Hypertension (Russian Federation) |
op_relation |
https://doi.org/10.18705/1607-419X-2018-24-4-469-477 https://repository.rudn.ru/records/article/record/36410/ |
op_doi |
https://doi.org/10.18705/1607-419X-2018-24-4-469-477 |
container_title |
"Arterial’naya Gipertenziya" ("Arterial Hypertension") |
container_volume |
24 |
container_issue |
4 |
container_start_page |
469 |
op_container_end_page |
477 |
_version_ |
1766181759928500224 |