Supplementary material: Figures, Tables, and dataset from Full allogeneic fusion of embryos in a holothuroid echinoderm
Whole-body chimaeras (organisms composed of genetically distinct cells) have been directly observed in modular/colonial organisms (e.g. corals, sponges, ascidians); whereas in unitary deuterostosmes (including mammals) they have only been detected indirectly through molecular analysis. Here, we docu...
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ftroysocietyfig:oai:figshare.com:article/6270392 2023-05-15T15:59:38+02:00 Supplementary material: Figures, Tables, and dataset from Full allogeneic fusion of embryos in a holothuroid echinoderm Bruno L. Gianasi Jean-François Hamel Annie Mercier 2018-05-15T16:15:07Z https://doi.org/10.6084/m9.figshare.6270392.v1 https://figshare.com/articles/journal_contribution/Supplementary_material_Figures_Tables_and_dataset_from_Full_allogeneic_fusion_of_embryos_in_a_holothuroid_echinoderm/6270392 unknown doi:10.6084/m9.figshare.6270392.v1 https://figshare.com/articles/journal_contribution/Supplementary_material_Figures_Tables_and_dataset_from_Full_allogeneic_fusion_of_embryos_in_a_holothuroid_echinoderm/6270392 CC BY 4.0 CC-BY Ecology Developmental Biology Animal Behaviour fusion sea cucumbers chimaera genetic heterogeneity allorecognition Text Journal contribution 2018 ftroysocietyfig https://doi.org/10.6084/m9.figshare.6270392.v1 2022-01-01T19:47:55Z Whole-body chimaeras (organisms composed of genetically distinct cells) have been directly observed in modular/colonial organisms (e.g. corals, sponges, ascidians); whereas in unitary deuterostosmes (including mammals) they have only been detected indirectly through molecular analysis. Here, we documented for the first time the step-by-step development of whole-body chimaeras in the holothuroid Cucumaria frondosa , a unitary deuterostome belonging to the phylum Echinodermata. To the best of our knowledge, this is the most derived unitary metazoan in which direct investigation of zygote fusibility has been undertaken. Fusion occurred among hatched blastulae, never during earlier (unhatched) or later (larval) stages. The fully fused chimaeric propagules were two to five times larger than non-chimaeric embryos. Fusion was positively correlated with propagule density and facilitated by the natural tendency of early embryos to agglomerate. The discovery of natural chimaerism in a unitary deuterostome that possesses large externally fertilized eggs provides a framework to explore key aspects of evolutionary biology, histocompatibility and cell transplantation in biomedical research. Other Non-Article Part of Journal/Newspaper Cucumaria frondosa The Royal Society: Figshare |
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Open Polar |
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The Royal Society: Figshare |
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ftroysocietyfig |
language |
unknown |
topic |
Ecology Developmental Biology Animal Behaviour fusion sea cucumbers chimaera genetic heterogeneity allorecognition |
spellingShingle |
Ecology Developmental Biology Animal Behaviour fusion sea cucumbers chimaera genetic heterogeneity allorecognition Bruno L. Gianasi Jean-François Hamel Annie Mercier Supplementary material: Figures, Tables, and dataset from Full allogeneic fusion of embryos in a holothuroid echinoderm |
topic_facet |
Ecology Developmental Biology Animal Behaviour fusion sea cucumbers chimaera genetic heterogeneity allorecognition |
description |
Whole-body chimaeras (organisms composed of genetically distinct cells) have been directly observed in modular/colonial organisms (e.g. corals, sponges, ascidians); whereas in unitary deuterostosmes (including mammals) they have only been detected indirectly through molecular analysis. Here, we documented for the first time the step-by-step development of whole-body chimaeras in the holothuroid Cucumaria frondosa , a unitary deuterostome belonging to the phylum Echinodermata. To the best of our knowledge, this is the most derived unitary metazoan in which direct investigation of zygote fusibility has been undertaken. Fusion occurred among hatched blastulae, never during earlier (unhatched) or later (larval) stages. The fully fused chimaeric propagules were two to five times larger than non-chimaeric embryos. Fusion was positively correlated with propagule density and facilitated by the natural tendency of early embryos to agglomerate. The discovery of natural chimaerism in a unitary deuterostome that possesses large externally fertilized eggs provides a framework to explore key aspects of evolutionary biology, histocompatibility and cell transplantation in biomedical research. |
format |
Other Non-Article Part of Journal/Newspaper |
author |
Bruno L. Gianasi Jean-François Hamel Annie Mercier |
author_facet |
Bruno L. Gianasi Jean-François Hamel Annie Mercier |
author_sort |
Bruno L. Gianasi |
title |
Supplementary material: Figures, Tables, and dataset from Full allogeneic fusion of embryos in a holothuroid echinoderm |
title_short |
Supplementary material: Figures, Tables, and dataset from Full allogeneic fusion of embryos in a holothuroid echinoderm |
title_full |
Supplementary material: Figures, Tables, and dataset from Full allogeneic fusion of embryos in a holothuroid echinoderm |
title_fullStr |
Supplementary material: Figures, Tables, and dataset from Full allogeneic fusion of embryos in a holothuroid echinoderm |
title_full_unstemmed |
Supplementary material: Figures, Tables, and dataset from Full allogeneic fusion of embryos in a holothuroid echinoderm |
title_sort |
supplementary material: figures, tables, and dataset from full allogeneic fusion of embryos in a holothuroid echinoderm |
publishDate |
2018 |
url |
https://doi.org/10.6084/m9.figshare.6270392.v1 https://figshare.com/articles/journal_contribution/Supplementary_material_Figures_Tables_and_dataset_from_Full_allogeneic_fusion_of_embryos_in_a_holothuroid_echinoderm/6270392 |
genre |
Cucumaria frondosa |
genre_facet |
Cucumaria frondosa |
op_relation |
doi:10.6084/m9.figshare.6270392.v1 https://figshare.com/articles/journal_contribution/Supplementary_material_Figures_Tables_and_dataset_from_Full_allogeneic_fusion_of_embryos_in_a_holothuroid_echinoderm/6270392 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.6270392.v1 |
_version_ |
1766395569097408512 |