Sex specific data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis
Telomere length (TL) has become a biomarker of increasing interest within ecology and evolutionary biology, and has been found to predict subsequent survival in some recent avian studies but not others. Here, we undertake the first formal meta-analysis to test whether there is an overall association...
Main Authors: | , , , , , |
---|---|
Format: | Dataset |
Language: | unknown |
Published: |
2017
|
Subjects: | |
Online Access: | https://doi.org/10.6084/m9.figshare.5705812.v1 https://figshare.com/articles/dataset/Sex_specific_data_from_The_relationship_between_telomere_length_and_mortality_risk_in_non-model_vertebrate_systems_a_meta-analysis/5705812 |
id |
ftroysocietyfig:oai:figshare.com:article/5705812 |
---|---|
record_format |
openpolar |
spelling |
ftroysocietyfig:oai:figshare.com:article/5705812 2023-05-15T15:34:41+02:00 Sex specific data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis Rachael V. Wilbourn Joshua P. Moatt Hannah Froy Craig A. Walling Daniel H. Nussey Jelle J. Boonekamp 2017-12-15T12:44:21Z https://doi.org/10.6084/m9.figshare.5705812.v1 https://figshare.com/articles/dataset/Sex_specific_data_from_The_relationship_between_telomere_length_and_mortality_risk_in_non-model_vertebrate_systems_a_meta-analysis/5705812 unknown doi:10.6084/m9.figshare.5705812.v1 https://figshare.com/articles/dataset/Sex_specific_data_from_The_relationship_between_telomere_length_and_mortality_risk_in_non-model_vertebrate_systems_a_meta-analysis/5705812 CC BY CC-BY Evolutionary Biology Ecology survival longevity systematic review wild publication bias Dataset 2017 ftroysocietyfig https://doi.org/10.6084/m9.figshare.5705812.v1 2022-01-01T19:50:55Z Telomere length (TL) has become a biomarker of increasing interest within ecology and evolutionary biology, and has been found to predict subsequent survival in some recent avian studies but not others. Here, we undertake the first formal meta-analysis to test whether there is an overall association between TL and subsequent mortality risk in vertebrates other than humans and model laboratory rodents. We identified 27 suitable studies and obtained standardized estimates of the hazard ratio associated with TL from each. We performed a meta-analysis on these estimates and found an overall significant negative association implying that short telomeres are associated with increased mortality risk, which was robust to evident publication bias. While we found that heterogeneity in the hazard ratios was not explained by sex, follow-up period, maximum lifespan or the age group of the study animals, the TL–mortality risk association was stronger in studies using qPCR compared to terminal restriction fragment methodologies. Our results provide support for a consistent association between short telomeres and increased mortality risk in birds, but also highlight the need for more research into non-avian vertebrates and the reasons why different telomere measurement methods may yield different results.This article is part of the theme issue ‘Understanding diversity in telomere dynamics’. Dataset Avian Studies The Royal Society: Figshare |
institution |
Open Polar |
collection |
The Royal Society: Figshare |
op_collection_id |
ftroysocietyfig |
language |
unknown |
topic |
Evolutionary Biology Ecology survival longevity systematic review wild publication bias |
spellingShingle |
Evolutionary Biology Ecology survival longevity systematic review wild publication bias Rachael V. Wilbourn Joshua P. Moatt Hannah Froy Craig A. Walling Daniel H. Nussey Jelle J. Boonekamp Sex specific data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
topic_facet |
Evolutionary Biology Ecology survival longevity systematic review wild publication bias |
description |
Telomere length (TL) has become a biomarker of increasing interest within ecology and evolutionary biology, and has been found to predict subsequent survival in some recent avian studies but not others. Here, we undertake the first formal meta-analysis to test whether there is an overall association between TL and subsequent mortality risk in vertebrates other than humans and model laboratory rodents. We identified 27 suitable studies and obtained standardized estimates of the hazard ratio associated with TL from each. We performed a meta-analysis on these estimates and found an overall significant negative association implying that short telomeres are associated with increased mortality risk, which was robust to evident publication bias. While we found that heterogeneity in the hazard ratios was not explained by sex, follow-up period, maximum lifespan or the age group of the study animals, the TL–mortality risk association was stronger in studies using qPCR compared to terminal restriction fragment methodologies. Our results provide support for a consistent association between short telomeres and increased mortality risk in birds, but also highlight the need for more research into non-avian vertebrates and the reasons why different telomere measurement methods may yield different results.This article is part of the theme issue ‘Understanding diversity in telomere dynamics’. |
format |
Dataset |
author |
Rachael V. Wilbourn Joshua P. Moatt Hannah Froy Craig A. Walling Daniel H. Nussey Jelle J. Boonekamp |
author_facet |
Rachael V. Wilbourn Joshua P. Moatt Hannah Froy Craig A. Walling Daniel H. Nussey Jelle J. Boonekamp |
author_sort |
Rachael V. Wilbourn |
title |
Sex specific data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
title_short |
Sex specific data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
title_full |
Sex specific data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
title_fullStr |
Sex specific data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
title_full_unstemmed |
Sex specific data from The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
title_sort |
sex specific data from the relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis |
publishDate |
2017 |
url |
https://doi.org/10.6084/m9.figshare.5705812.v1 https://figshare.com/articles/dataset/Sex_specific_data_from_The_relationship_between_telomere_length_and_mortality_risk_in_non-model_vertebrate_systems_a_meta-analysis/5705812 |
genre |
Avian Studies |
genre_facet |
Avian Studies |
op_relation |
doi:10.6084/m9.figshare.5705812.v1 https://figshare.com/articles/dataset/Sex_specific_data_from_The_relationship_between_telomere_length_and_mortality_risk_in_non-model_vertebrate_systems_a_meta-analysis/5705812 |
op_rights |
CC BY |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.5705812.v1 |
_version_ |
1766364993445429248 |